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Gene · 10594

PRPF8: pre-mRNA processing factor 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PRPF8: pre-mRNA processing factor 8. Genes, record 10594. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10594

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Gene

Symbol
PRPF8
HGNC
Name
pre-mRNA processing factor 8
HGNC
NCBI Gene ID
10594
NCBI Gene
HGNC ID
HGNC:17340
HGNC
Ensembl
ENSG00000174231
NCBI Gene
Aliases
HPRP8, PRP8, PRPC8, Prp8, RP13, SNRNP220, hPrp8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q6P2Q9Pre-mRNA-processing-splicing factor 82,335101Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19258Q6P2Q9Espacenet
JP 2026004568 A2026-01-1460417Q6P2Q9Espacenet
EP 4667578 A22025-12-24157Q6P2Q9Espacenet
EP 4650780 A22025-11-194268Q6P2Q9Espacenet
EP 4641201 A22025-10-293828Q6P2Q9Espacenet
JP 2025131621 A2025-09-09157Q6P2Q9Espacenet
JP 2025517969 A2025-06-123828Q6P2Q9Espacenet
JP 2025517970 A2025-06-124268Q6P2Q9Espacenet
WO 2024240908 A12024-11-2831Q6P2Q9Espacenet
WO 2024214081 A12024-10-17258Q6P2Q9Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,221

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePRPF8 papersNewest fiscal year
R01EY018213Defining Barriers to Gene Therapy92025
P30CA008748Cancer Center Support Grant72025
P30CA013696Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant62025
R01EY024698Gene Editing and Silencing in Phototransduction62025
P30CA091842Cancer Center Support Grant52025
P30EY014104P30 Core Grant for Vision Research52025
R01EY022356Molecular Basis of Human Visual System Disorders52025
R01HL128239Genetic and molecular basis for SRSF2 mutations in myelodysplasia52025
P30CA036727Buffett Cancer Center Support Grant42025

1 to 10 of 1,221Source NIH's project files

See all 1,221 nih grants

Papers1,565

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Case of Acute Lymphoblastic Leukemia Developing After a Diagnosis of Myelodysplastic Syndrome Following Lenalidomide Therapy for Multiple Myeloma.Intern Med202642778383PubTator, text miningPubMed
The evolutionarily conserved C-terminal tail of the Dib1 protein is required for spliceosome efficacy and Dib1 protein stability.J Biol Chem202642556727PubTator, text miningPubMed
The spliceosome's secret life: pRP8 silences transposons through 3D chromatin organization.Plant Cell202642550921PubTator, text miningPubMed
Neurochondrin promotes U5 snRNP maturation by regulating AAR2 release from PRPF8.Nucleic Acids Res202642411410PubTator, text miningPubMed
The landscape of variants in pre-mRNA-processing factor genes in an Irish cohort.Genet Med Open202642405195PubTator, text miningPubMed
Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase.Nat Commun202642399621PubTator, text miningPubMed
Environmental Pollutant PCB 153 Is Associated with Candidate Alternative Splicing Alterations in Intellectual Disability-Associated Genes: An Exploratory RNA-Seq Splicing Analysis in a Neuronal Model.Genes (Basel)202642353851PubTator, text miningPubMed
PRP8 regulates chromatin organization to enforce transcriptional gene silencing independent of DNA methylation.Plant Cell202642252934PubTator, text miningPubMed
Optical Genome Mapping Reveals Frequent Cryptic Structural Aberrations in Normal Karyotype Acute Myeloid Leukemia.Int J Cancer202642132347PubTator, text miningPubMed
The tumour suppressor RBM5 activates the helicase DHX15 to regulate splicing.Res Sq202641994107PubTator, text miningPubMed

1 to 10 of 1,565

See all 1,565 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10594

GET https://conductscience.org/api/genes/v1/10594/patents?page=2