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Gene · 10643

IGF2BP3: insulin like growth factor 2 mRNA binding protein 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IGF2BP3: insulin like growth factor 2 mRNA binding protein 3. Genes, record 10643. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10643

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Gene

Symbol
IGF2BP3
HGNC
Name
insulin like growth factor 2 mRNA binding protein 3
HGNC
NCBI Gene ID
10643
NCBI Gene
HGNC ID
HGNC:28868
HGNC
Ensembl
ENSG00000136231
NCBI Gene
Aliases
CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00425Insulin-like growth factor 2 mRNA-binding protein 35795Ensembl, GeneID, HGNC

Source UniProt

Patents88

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449921O00425Espacenet
EP 4641201 A22025-10-291310O00425Espacenet
EP 4641202 A22025-10-294495O00425Espacenet
JP 2025517969 A2025-06-121310O00425Espacenet
KR 1020250036258 A2025-03-1332O00425Espacenet
KR 1020250017231 A2025-02-044495O00425Espacenet
EP 4487869 A22025-01-08231O00425Espacenet
US 12023371 B22024-07-024652O00425Espacenet
EP 4353321 A22024-04-17110O00425Espacenet
KR 1020240027895 A2024-03-04423O00425Espacenet

1 to 10 of 88

See all 88 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants947

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIGF2BP3 papersNewest fiscal year
P30CA016042Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant52025
T32CA009056Tumor Cell Biology Training Program52025
P50AA011999Southern California Research Center for ALPD and Cirrhosis42025
R01CA264986Protein-RNA interactions in cancer42025
R24AA012885Integrative Liver Cell Core42025
P30CA008748Cancer Center Support Grant32025
P30CA016058Cancer Center Support Grant32025
P30CA016086Cancer Center Support Grant32025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant32025

1 to 10 of 947Source NIH's project files

See all 947 nih grants

Papers3,038

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
IGF2BP3 promotes esophageal squamous cell carcinoma progression by regulating global protein translation.Biochim Biophys Acta Mol Basis Dis202742603622PubTator, text miningPubMed
IGF2BP3 remodels RISC occupancy to control microRNA targeting in leukemia.NAR Cancer202642780509PubTator, text miningPubMed
A Metabolic-Epigenetic Axis of AARS1/IGF2BP3-K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence.Adv Sci (Weinh)202642775431PubTator, text miningPubMed
IGF2BP3 drives macrophage M1 polarization to promote intracranial aneurysm rupture through m6A-mediated NPY1R stabilization.Peptides202642772570PubTator, text miningPubMed
Programmed ribosomal frameshifting triggers translational stress to promote viral replication.Cell202642743925PubTator, text miningPubMed
Development of m6A-related prognostic models for survival in lung squamous cell carcinoma with different PD-L1 expression levels.Transl Cancer Res202642724890PubTator, text miningPubMed
IGF2BP3 enhances paclitaxel resistance in bladder urothelial carcinoma by recognizing m6A-modified CENPA mRNA.Med Oncol202642720822PubTator, text miningPubMed
Correction to "IGF2BP3-Dependent N6-Methyladenosine Modification of USP49 Promotes Carboplatin Resistance in Retinoblastoma by Enhancing Autophagy via Regulating the Stabilization of SIRT1".Kaohsiung J Med Sci202642717291PubTator, text miningPubMed
WTAP-mediated m6A modification upregulates the circCDK8 to promote ferroptosis in periodontal ligament stem cells.Biochem Pharmacol202642679908PubTator, text miningPubMed
Role and prognostic value of N6-methyladenosine RNA modification regulators in glycolytic reprogramming during sepsis.J Intensive Care202642675521PubTator, text miningPubMed

1 to 10 of 3,038

See all 3,038 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10643

GET https://conductscience.org/api/genes/v1/10643/patents?page=2