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Gene · 10644

IGF2BP2: insulin like growth factor 2 mRNA binding protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IGF2BP2: insulin like growth factor 2 mRNA binding protein 2. Genes, record 10644. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10644

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Gene

Symbol
IGF2BP2
HGNC
Name
insulin like growth factor 2 mRNA binding protein 2
HGNC
NCBI Gene ID
10644
NCBI Gene
HGNC ID
HGNC:28867
HGNC
Ensembl
ENSG00000073792
NCBI Gene
Aliases
IMP-2, IMP2, P62, VICKZ2, p62
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y6M1Insulin-like growth factor 2 mRNA-binding protein 25994Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449919Q9Y6M1Espacenet
EP 4650780 A22025-11-1910531Q9Y6M1Espacenet
JP 2025517970 A2025-06-1210531Q9Y6M1Espacenet
US 12023371 B22024-07-024649Q9Y6M1Espacenet
JP 2023533815 A2023-08-0419Q9Y6M1Espacenet
KR 1020230068378 A2023-05-1719Q9Y6M1Espacenet
US 11446398 B22022-09-2040589Q9Y6M1Espacenet
JP 2022524081 A2022-04-27143560Q9Y6M1Espacenet
US 10925935 B22021-02-234649Q9Y6M1Espacenet
WO 2020043864 A12020-03-051179Q9Y6M1Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,711

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIGF2BP2 papersNewest fiscal year
ZIAHG000024Genetic analysis of type II diabetes142025
P30DK020572Michigan Diabetes Research Center (MDRC)122025
P30DK063491Diabetes Research Center (DRC)102025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION102025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal102025
P30CA016672Cancer Center Support Grant72025
P30ES010126UNC Center for Environmental Health and Susceptibility72025
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits72025
P30CA068485Cancer Center Support Grant52025
P30DK017047Diabetes Research Center52025

1 to 10 of 1,711Source NIH's project files

See all 1,711 nih grants

Papers3,666

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Statement of Retraction: N6-methyladenosine reader YTH N6-methyladenosine RNA binding protein 3 or insulin like growth factor 2 mRNA binding protein 2 knockdown protects human bronchial epithelial cells from hypoxia/reoxygenation injury by inactivating p38 MAPK, AKT, ERK1/2, and NF-κB pathways.
Bioengineered202642826084PubTator, text miningPubMed
Statement of Retraction: N6-methyladenosine (m6A) reader IGF2BP2 promotes gastric cancer progression via targeting SIRT1.Bioengineered202642821770PubTator, text miningPubMed
An IGF2BP2-MYBL2-HMGB2 Signaling Axis Promotes Macrophage Immune Evasion in Hepatocellular Carcinoma.Cancer Commun (Lond)202642819712PubTator, text miningPubMed
METTL3 Increases Temozolomide Resistance in MGMT-Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m6A-IGF2BP2-Dependent Manner.CNS Neurosci Ther202642817804PubTator, text miningPubMed
SH2B3 Promotes PD-L1-Mediated Immune Evasion in Glioblastoma via BRCC3-Dependent IGF2BP2 Stabilization.Int J Biol Sci202642807322PubTator, text miningPubMed
Sublethal heat stress-induced HSF4 upregulation via GRSF1 in an m6A-dependent manner in hepatocellular carcinoma.Chin Med J (Engl)202642754818PubTator, text miningPubMed
CircRHBDD1(4,5) drives malignant progression of oral squamous cell carcinoma by enhancing DKK1 mRNA stability through facilitating m6A-dependent IGF2BP2 binding.Oncogene202642722719PubTator, text miningPubMed
Correction: METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma.Mol Cancer202642701193PubTator, text miningPubMed
METTL3-m6A-IGF2BP2 Axis-Mediated Stabilization of MTFR1 Promotes Glycolytic Reprogramming in Colorectal Cancer.J Gastroenterol Hepatol202642681996PubTator, text miningPubMed
The insulin-like growth factor 2 mRNA-binding protein 2 affects tumor cell metabolism via mitochondrial transporter activity and lipid alterations.Cell Death Discov202642680753PubTator, text miningPubMed

1 to 10 of 3,666

See all 3,666 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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