Gene · 10645
CAMKK2: calcium/calmodulin dependent protein kinase kinase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CAMKK2: calcium/calmodulin dependent protein kinase kinase 2. Genes, record 10645. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10645
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96RR4 | Calcium/calmodulin-dependent protein kinase kinase 2 | 588 | 24 | Ensembl, GeneID, HGNC |
Source UniProt
Patents48
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 4864 | Q96RR4 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4431 | Q96RR4 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 727 | Q96RR4 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 727 | Q96RR4 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4431 | Q96RR4 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4864 | Q96RR4 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10946 | Q96RR4 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10951 | Q96RR4 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10952 | Q96RR4 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 25719 | Q96RR4 | Espacenet |
1 to 10 of 48
See all 48 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,686
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CAMKK2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 17 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 8 | 2025 |
| P01CA120964 | Molecular Pathogenesis of the Hamartoma Syndromes | 6 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| P30CA012197 | Cancer Center Support Grant | 4 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 4 | 2025 |
| R01ES014901 | Molecular and Cellular Basis of PCB Developmental Neurotoxicity | 4 | 2025 |
| R01GM098535 | Molecular mechanisms of DNA damage signaling and repair | 4 | 2025 |
1 to 10 of 1,686Source NIH's project files
See all 1,686 nih grantsPapers2,799
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| [Activation of the CaMKKβ/AMPK/HIF-1α signaling pathway promotes angiogenesis in endometriosis by regulating mitophagy]. | Nan Fang Yi Ke Da Xue Xue Bao | 2026 | 42812051 | PubTator, text mining | PubMed |
| GLP-1 Receptor Agonists as Molecular Relievers of Lipotoxic Stress: From Pancreatic Beta-Cell Cholesterol Efflux to Systemic and Tissue-Specific Metabolic Protection. | Int J Mol Sci | 2026 | 42794805 | PubTator, text mining | PubMed |
| The expressions and m6A methylation modification patterns of mRNAs and lncRNAs in major depressive disorder. | Front Genet | 2026 | 42788145 | PubTator, text mining | PubMed |
| α7nAChR alleviates cognitive impairment by promoting autophagy in astrocytes via CaMKK2/AMPK/mTOR pathway in sepsis-associated encephalopathy. | Front Immunol | 2026 | 42760969 | PubTator, text mining | PubMed |
| ABCA1 as a Gatekeeper of Pancreatic β-Cell Cholesterol Homeostasis: Links Between Lipoprotein Stress, Lipotoxicity, and Insulin Secretion. | Nutrients | 2026 | 42739051 | PubTator, text mining | PubMed |
| AMPK phosphorylation proceeds through hierarchical proteoform cascades revealed by integrated mass spectrometry. | Sci Adv | 2026 | 42696602 | PubTator, text mining | PubMed |
| Activation phosphorylation and dephosphorylation dynamics of Ca2+/Calmodulin-dependent protein kinase Iα in HeLa cells. | Cell Calcium | 2026 | 42641287 | PubTator, text mining | PubMed |
| Isoform-specific modulation of PI3K/Akt1 signaling by Orai channels in estrogen receptor-positive breast cancer. | Am J Physiol Cell Physiol | 2026 | 42581031 | PubTator, text mining | PubMed |
| Senecavirus a 3C protease cleaves RETREG1 to antagonize ER-phagy and promote viral replication via endoplasmic reticulum calcium signaling. | Autophagy | 2026 | 42576627 | PubTator, text mining | PubMed |
| HMGB1 signalling in Alzheimer's disease: pathogenic roles and therapeutic prospects. | Int Immunopharmacol | 2026 | 42561665 | PubTator, text mining | PubMed |
1 to 10 of 2,799
See all 2,799 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10645
GET https://conductscience.org/api/genes/v1/10645/patents?page=2