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Gene · 10645

CAMKK2: calcium/calmodulin dependent protein kinase kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CAMKK2: calcium/calmodulin dependent protein kinase kinase 2. Genes, record 10645. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10645

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Gene

Symbol
CAMKK2
HGNC
Name
calcium/calmodulin dependent protein kinase kinase 2
HGNC
NCBI Gene ID
10645
NCBI Gene
HGNC ID
HGNC:1470
HGNC
Ensembl
ENSG00000110931
NCBI Gene
Aliases
CAMKK, CAMKKB, KIAA0787, MGC15254
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96RR4Calcium/calmodulin-dependent protein kinase kinase 258824Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194864Q96RR4Espacenet
EP 4641201 A22025-10-294431Q96RR4Espacenet
JP 2025529142 A2025-09-04727Q96RR4Espacenet
US 12371689 B22025-07-29727Q96RR4Espacenet
JP 2025517969 A2025-06-124431Q96RR4Espacenet
JP 2025517970 A2025-06-124864Q96RR4Espacenet
JP 2025062604 A2025-04-1410946Q96RR4Espacenet
JP 2025062604 A2025-04-1410951Q96RR4Espacenet
JP 2025062604 A2025-04-1410952Q96RR4Espacenet
JP 2025032204 A2025-03-1125719Q96RR4Espacenet

1 to 10 of 48

See all 48 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,686

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCAMKK2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant172025
P30CA016056Roswell Park Cancer Center Support Grant82025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes62025
P30CA014195Cancer Center Support Grant (CCSG)52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P30CA012197Cancer Center Support Grant42025
P30CA021765Cancer Center Support Grant (CCSG)42025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant42025
R01ES014901Molecular and Cellular Basis of PCB Developmental Neurotoxicity42025
R01GM098535Molecular mechanisms of DNA damage signaling and repair42025

1 to 10 of 1,686Source NIH's project files

See all 1,686 nih grants

Papers2,799

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
[Activation of the CaMKKβ/AMPK/HIF-1α signaling pathway promotes angiogenesis in endometriosis by regulating mitophagy].Nan Fang Yi Ke Da Xue Xue Bao202642812051PubTator, text miningPubMed
GLP-1 Receptor Agonists as Molecular Relievers of Lipotoxic Stress: From Pancreatic Beta-Cell Cholesterol Efflux to Systemic and Tissue-Specific Metabolic Protection.Int J Mol Sci202642794805PubTator, text miningPubMed
The expressions and m6A methylation modification patterns of mRNAs and lncRNAs in major depressive disorder.Front Genet202642788145PubTator, text miningPubMed
α7nAChR alleviates cognitive impairment by promoting autophagy in astrocytes via CaMKK2/AMPK/mTOR pathway in sepsis-associated encephalopathy.Front Immunol202642760969PubTator, text miningPubMed
ABCA1 as a Gatekeeper of Pancreatic β-Cell Cholesterol Homeostasis: Links Between Lipoprotein Stress, Lipotoxicity, and Insulin Secretion.Nutrients202642739051PubTator, text miningPubMed
AMPK phosphorylation proceeds through hierarchical proteoform cascades revealed by integrated mass spectrometry.Sci Adv202642696602PubTator, text miningPubMed
Activation phosphorylation and dephosphorylation dynamics of Ca2+/Calmodulin-dependent protein kinase Iα in HeLa cells.Cell Calcium202642641287PubTator, text miningPubMed
Isoform-specific modulation of PI3K/Akt1 signaling by Orai channels in estrogen receptor-positive breast cancer.Am J Physiol Cell Physiol202642581031PubTator, text miningPubMed
Senecavirus a 3C protease cleaves RETREG1 to antagonize ER-phagy and promote viral replication via endoplasmic reticulum calcium signaling.Autophagy202642576627PubTator, text miningPubMed
HMGB1 signalling in Alzheimer's disease: pathogenic roles and therapeutic prospects.Int Immunopharmacol202642561665PubTator, text miningPubMed

1 to 10 of 2,799

See all 2,799 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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