Gene · 1066
CES1: carboxylesterase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CES1: carboxylesterase 1. Genes, record 1066. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1066
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P23141 | Liver carboxylesterase 1 | 567 | 21 | Ensembl, GeneID, HGNC |
Source UniProt
Patents30
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 40040 | P23141 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8025 | P23141 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8140 | P23141 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 2634 | P23141 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5831 | P23141 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5831 | P23141 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8140 | P23141 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8025 | P23141 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 11774 | P23141 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 2634 | P23141 | Espacenet |
1 to 10 of 30
See all 30 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,601
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CES1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA021765 | Cancer Center Support Grant (CCSG) | 30 | 2025 |
| R01DK102619 | Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver Disease | 7 | 2025 |
| R01HD081299 | Ontogeny of drug transport | 6 | 2025 |
| P30AI050409 | Center for AIDS Research at Emory University | 5 | 2025 |
| R01CA142746 | Subcellular enzyme-instructed self-assembly for molecular anticancer nanomedicines | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| T32AA007462 | Training Grant on Genetic Aspects of Alcoholism | 4 | 2025 |
| U54MD007600 | Center for Collaborative Research in Health Disparities | 4 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,601Source NIH's project files
See all 1,601 nih grantsPapers3,256
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| An ultra-sensitive liquid chromatography-fluorescence detection method for determining hCE1 activity and evaluation of hCE1 as a biomarker of liver injury. | J Pharm Biomed Anal | 2027 | 42691704 | PubTator, text mining | PubMed |
| Multiscale Transcriptomic and Molecular Modeling Analyses Suggest DCPMU-Associated Epithelial Remodeling and Tumor Microenvironment Perturbation in Prostate Cancer. | Curr Issues Mol Biol | 2026 | 42793291 | PubTator, text mining | PubMed |
| Structure-based molecular modeling of a novel S-Remiketamine scaffold and derived arylcyclohexanone analogues: NMDA receptor dynamics, MM-GBSA ranking, and CES1-Oriented structural compatibility. | Front Chem | 2026 | 42756372 | PubTator, text mining | PubMed |
| The influence of human plasma on drug-metabolizing enzymes: an exploratory study. | Xenobiotica | 2026 | 42742947 | PubTator, text mining | PubMed |
| Cancer-associated fibroblasts drive immune resistance in MSS colorectal cancer via the FAIM2-CES1-ER stress pathway. | Mol Cell Biochem | 2026 | 42742855 | PubTator, text mining | PubMed |
| Integrated transcriptome analysis and machine learning to construct a homeostatic model of acetylation for bladder cancer and validate the key gene CES1. | Transl Androl Urol | 2026 | 42729074 | PubTator, text mining | PubMed |
| Recent research progress on the mechanisms of clopidogrel resistance. | Eur J Clin Pharmacol | 2026 | 42706349 | PubTator, text mining | PubMed |
| Vitamin E treatment modulates steatotic and attenuates oxidative stress in a MASLD in vitro model. | Mol Biol Rep | 2026 | 42704499 | PubTator, text mining | PubMed |
| [p.Gly143Glu Variant in CES1 Gene Associated with an Adverse Response to Methylphenidate in a Child: Case Report]. | Acta Med Port | 2026 | 42697867 | PubTator, text mining | PubMed |
| Integrating target prediction and transcriptomic analysis identifies the AKR1C2-KRT8 axis in rotenone-induced dopaminergic neuron injury. | Brain Res Bull | 2026 | 42679909 | PubTator, text mining | PubMed |
1 to 10 of 3,256
See all 3,256 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1066
GET https://conductscience.org/api/genes/v1/1066/patents?page=2