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Gene · 1066

CES1: carboxylesterase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CES1: carboxylesterase 1. Genes, record 1066. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1066

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Gene

Symbol
CES1
HGNC
Name
carboxylesterase 1
HGNC
NCBI Gene ID
1066
NCBI Gene
HGNC ID
HGNC:1863
HGNC
Ensembl
ENSG00000198848
NCBI Gene
Aliases
ACAT, CE-1, CEH, CES1A1, CES1A2, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P23141Liver carboxylesterase 156721Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440040P23141Espacenet
EP 4650780 A22025-11-198025P23141Espacenet
EP 4641201 A22025-10-298140P23141Espacenet
JP 2025147176 A2025-10-062634P23141Espacenet
JP 2025529142 A2025-09-045831P23141Espacenet
US 12371689 B22025-07-295831P23141Espacenet
JP 2025517969 A2025-06-128140P23141Espacenet
JP 2025517970 A2025-06-128025P23141Espacenet
JP 2025062604 A2025-04-1411774P23141Espacenet
JP 2025028160 A2025-02-282634P23141Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,601

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCES1 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)302025
R01DK102619Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver Disease72025
R01HD081299Ontogeny of drug transport62025
P30AI050409Center for AIDS Research at Emory University52025
R01CA142746Subcellular enzyme-instructed self-assembly for molecular anticancer nanomedicines52025
P30CA008748Cancer Center Support Grant42025
T32AA007462Training Grant on Genetic Aspects of Alcoholism42025
U54MD007600Center for Collaborative Research in Health Disparities42025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA016059Massey Cancer Center - Cancer Center Support Grant32025

1 to 10 of 1,601Source NIH's project files

See all 1,601 nih grants

Papers3,256

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
An ultra-sensitive liquid chromatography-fluorescence detection method for determining hCE1 activity and evaluation of hCE1 as a biomarker of liver injury.J Pharm Biomed Anal202742691704PubTator, text miningPubMed
Multiscale Transcriptomic and Molecular Modeling Analyses Suggest DCPMU-Associated Epithelial Remodeling and Tumor Microenvironment Perturbation in Prostate Cancer.Curr Issues Mol Biol202642793291PubTator, text miningPubMed
Structure-based molecular modeling of a novel S-Remiketamine scaffold and derived arylcyclohexanone analogues: NMDA receptor dynamics, MM-GBSA ranking, and CES1-Oriented structural compatibility.Front Chem202642756372PubTator, text miningPubMed
The influence of human plasma on drug-metabolizing enzymes: an exploratory study.Xenobiotica202642742947PubTator, text miningPubMed
Cancer-associated fibroblasts drive immune resistance in MSS colorectal cancer via the FAIM2-CES1-ER stress pathway.Mol Cell Biochem202642742855PubTator, text miningPubMed
Integrated transcriptome analysis and machine learning to construct a homeostatic model of acetylation for bladder cancer and validate the key gene CES1.Transl Androl Urol202642729074PubTator, text miningPubMed
Recent research progress on the mechanisms of clopidogrel resistance.Eur J Clin Pharmacol202642706349PubTator, text miningPubMed
Vitamin E treatment modulates steatotic and attenuates oxidative stress in a MASLD in vitro model.Mol Biol Rep202642704499PubTator, text miningPubMed
[p.Gly143Glu Variant in CES1 Gene Associated with an Adverse Response to Methylphenidate in a Child: Case Report].Acta Med Port202642697867PubTator, text miningPubMed
Integrating target prediction and transcriptomic analysis identifies the AKR1C2-KRT8 axis in rotenone-induced dopaminergic neuron injury.Brain Res Bull202642679909PubTator, text miningPubMed

1 to 10 of 3,256

See all 3,256 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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