ConductScience.org, home

Gene · 10661

KLF1: KLF transcription factor 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. KLF1: KLF transcription factor 1. Genes, record 10661. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10661

On this page

Gene

Symbol
KLF1
HGNC
Name
KLF transcription factor 1
HGNC
NCBI Gene ID
10661
NCBI Gene
HGNC ID
HGNC:6345
HGNC
Ensembl
ENSG00000105610
NCBI Gene
Aliases
CDAN4A, CDAN4B, EKLF, EKLF/KLF1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13351Krueppel-like factor 13623Ensembl, GeneID, HGNC

Source UniProt

Patents62

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-29291Q13351Espacenet
EP 4641201 A22025-10-291984Q13351Espacenet
JP 2025147176 A2025-10-0615207Q13351Espacenet
JP 2025519096 A2025-06-24291Q13351Espacenet
JP 2025517969 A2025-06-121984Q13351Espacenet
EP 4553154 A12025-05-141Q13351Espacenet
JP 2025028160 A2025-02-2815207Q13351Espacenet
WO 2025024334 A12025-01-30297Q13351Espacenet
KR 1020250010750 A2025-01-2115207Q13351Espacenet
JP 2024123008 A2024-09-106783Q13351Espacenet

1 to 10 of 62

See all 62 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,305

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKLF1 papersNewest fiscal year
R01DK103794Systematic Genetic Dissection of Human Erythropoiesis182025
P30CA021765Cancer Center Support Grant (CCSG)102025
P30CA008748Cancer Center Support Grant92025
P30CA016059Massey Cancer Center - Cancer Center Support Grant82025
R01DK054937Transcriptional Networks Controlling Erythroid Differentiation82025
U54DK106829Stem Cell and Transplantation Biology62025
P01CA108671Myeloproliferative Neoplasms-Research Consortium52025
R01HL119479Regulation of Hemoglobin Switching52025
P30CA013330Cancer Center Support Grant42025
P30CA015704Cancer Center Support Grant42025

1 to 10 of 1,305Source NIH's project files

See all 1,305 nih grants

Papers1,816

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Decoding the erythroid niche: From single-cell programs to spatially resolved architecture in mouse and human hematopoiesis.Curr Top Dev Biol202642754319PubTator, text miningPubMed
Interplay between fibroblast growth factor 9 (FGF9) and CD44 underlies 46,XY disorders of sex development in Kruppel-like factor 1 (KLF-1)-E325K-associated congenital dyserythropoietic anaemia (CDA-IV).
Br J Haematol202642753106PubTator, text miningPubMed
HIF1α-KLF4 signaling dictates extra-erythrocyte expression of hemoglobin conferring sorafenib resistance in hepatocellular carcinoma.Signal Transduct Target Ther202642744801PubTator, text miningPubMed
KLF1 mutation-associated congenital dyserythropoietic anemia type IV: a case report and literature review.Front Pediatr202642597595PubTator, text miningPubMed
The FOLR2-IRF2BP2 axis mediates erythropoiesis impairment by excess folic acid in myelodysplastic neoplasms.Leukemia202642575953PubTator, text miningPubMed
Novel variants of the KLF1 gene associated with the In(Lu) phenotype lead to alterations in protein structure.Transfus Med202642402990PubTator, text miningPubMed
Newborns with sickle cell trait have distinct peripheral blood molecular signatures across the first week of life.Blood Red Cells Iron202642368247PubTator, text miningPubMed
ZEB1 drives terminal erythroid maturation by controlling the GATA2-KLF1 regulatory switch.Nucleic Acids Res202642331751PubTator, text miningPubMed
Retinoic acid as a stage-specific modulator of hematopoietic lineage fate from human pluripotent stem cells.Cell Commun Signal202642321817PubTator, text miningPubMed
Comprehensive molecular characterization of treatment-free remission and molecular relapse in chronic myeloid leukemia patients: the EURO-SKI Biomarker Study.Leukemia202642315627PubTator, text miningPubMed

1 to 10 of 1,816

See all 1,816 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10661

GET https://conductscience.org/api/genes/v1/10661/patents?page=2