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CTCF: CCCTC-binding factor

1 protein, 32 patents, 0 drugs, 0 trials, 8,544 NIH grants and 11,585 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCTCFHGNC
NameCCCTC-binding factorHGNC
NCBI Gene ID10664NCBI Gene
HGNC IDHGNC:13723HGNC
EnsemblENSG00000102974NCBI Gene
AliasesCFAP108, FAP108, MRD21NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P49711Transcriptional repressor CTCF72721Ensembl, GeneID, HGNCUniProt

Patents 32

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4698657 A22026-02-25372P49711Espacenet
EP 4641201 A22025-10-291855P49711Espacenet
JP 2025147176 A2025-10-0614856P49711Espacenet
JP 2025517969 A2025-06-121855P49711Espacenet
JP 2025028160 A2025-02-2814856P49711Espacenet
KR 1020250010750 A2025-01-2114856P49711Espacenet
JP 2024123008 A2024-09-105426P49711Espacenet
JP 2024109657 A2024-08-1414695P49711Espacenet
US 11446398 B22022-09-2012706P49711Espacenet
US 11357853 B22022-06-1426P49711Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 8544

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant832,025NIH's project files
R01HG003143Structural Annotation of the Human Genome592,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program502,025NIH's project files
ZIAAI000860Deciphering CTCF code in human host and viral epigenomes462,025NIH's project files
P30CA016672Cancer Center Support Grant402,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)352,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant312,025NIH's project files
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)292,025NIH's project files
R01DE017336Epigenetic Regulation of Epstein-Barr Virus282,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant242,025NIH's project files

Papers 11585

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827183PubTator, text miningPubMed
42822246PubTator, text miningPubMed
42818845PubTator, text miningPubMed
42818186PubTator, text miningPubMed
42811810PubTator, text miningPubMed
42801620PubTator, text miningPubMed
42792888PubTator, text miningPubMed
42779822PubTator, text miningPubMed
42778791PubTator, text miningPubMed
42767818PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license