Gene · 10714
POLD3: DNA polymerase delta 3, accessory subunit
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. POLD3: DNA polymerase delta 3, accessory subunit. Genes, record 10714. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10714
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15054 | DNA polymerase delta subunit 3 | 466 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents25
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 2240 | Q15054 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1811 | Q15054 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1811 | Q15054 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2240 | Q15054 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 334 | Q15054 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7792 | Q15054 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 334 | Q15054 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 64993 | Q15054 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 167964 | Q15054 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 8700 | Q15054 | Espacenet |
1 to 10 of 25
See all 25 patentsDrugs7
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ASPACYTARABINE | CHEMBL4297599 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
| CLOFARABINE | CHEMBL1750 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
| CYTARABINE | CHEMBL803 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
| FLUDARABINE PHOSPHATE | CHEMBL1096882 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
| GEMCITABINE | CHEMBL888 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
| GEMCITABINE HYDROCHLORIDE | CHEMBL1637 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
| TROXACITABINE | CHEMBL359164 | DNA polymerase (alpha/delta/epsilon) inhibitor | INHIBITOR | ChEMBL |
Trials4,186
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604766 | GEMCITABINE | PHASE3 | ClinicalTrials.gov | |
| NCT07604233 | CYTARABINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07603557 | FLUDARABINE PHOSPHATE | PHASE2 | ClinicalTrials.gov | |
| NCT07602140 | GEMCITABINE | PHASE2 | ClinicalTrials.gov | |
| NCT07598318 | GEMCITABINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07588360 | CYTARABINE | ClinicalTrials.gov | ||
| NCT07583888 | CYTARABINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07579195 | GEMCITABINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07575191 | GEMCITABINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07570849 | GEMCITABINE | PHASE2 | ClinicalTrials.gov |
1 to 10 of 4,186
See all 4,186 trialsNIH grants1,731
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | POLD3 papers | Newest fiscal year |
|---|---|---|---|
| P30AI036219 | Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR) | 9 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 8 | 2025 |
| P30AI027767 | UAB Center for AIDS Research (CFAR) | 7 | 2025 |
| P30AI050409 | Center for AIDS Research at Emory University | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 7 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 6 | 2025 |
| U01CA167551 | Colon Cancer Family Registry Cohort | 6 | 2025 |
1 to 10 of 1,731Source NIH's project files
See all 1,731 nih grantsPapers2,359
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Western Blot Band Profiles and Their Associations with Demographic Characteristics, Transmission Routes, and Immune Status among HIV-1 Infected Individuals in Quzhou, China (2016-2024). | Curr HIV Res | 2026 | 42736695 | PubTator, text mining | PubMed |
| R-loops in colorectal cancer: mechanisms, mapping strategies, and therapeutic opportunities. | Mol Biol Rep | 2026 | 42593691 | PubTator, text mining | PubMed |
| Tumoral switch in NUMB splicing changes essential transcription pathways and induces malignant properties in tumour cells. | Genome Biol | 2026 | 42343463 | PubTator, text mining | PubMed |
| Loss of Pol32, a subunit of DNA polymerases δ and ζ, leads to different patterns of genome stability than direct impairment of these individual polymerases. | mBio | 2026 | 41995324 | PubTator, text mining | PubMed |
| Characterization of Borrelia-Derived Extracellular Vesicles: Implications for Pathogenesis and Diagnostics. | Microorganisms | 2026 | 41900360 | PubTator, text mining | PubMed |
| Cruciform-forming AT/TA repeats are acted upon by structure-selective endonucleases and Rad51 prior to repositioning to the nuclear periphery for repair. | Nucleic Acids Res | 2026 | 41805125 | PubTator, text mining | PubMed |
| Systematic Identification of Molecular Signatures Dictating Therapeutic Effects of Clinically First-Line Chemotherapy Regimens for Human Gastric Cancer Patients Based on Organoid Model. | MedComm (2020) | 2026 | 41782964 | PubTator, text mining | PubMed |
| Meeting abstracts from the Annual Conference "Clinical Genetics of Cancer 2024". | Hered Cancer Clin Pract | 2026 | 41781972 | PubTator, text mining | PubMed |
| Transient elevation in cellular glucose uptake exacerbates pressure overload-induced cardiac hypertrophy and dysfunction. | Epigenetics | 2026 | 41779017 | PubTator, text mining | PubMed |
| Mitotic microhomology-mediated break-induced replication promotes chromoanasynthesis. | Nat Commun | 2026 | 41775729 | PubTator, text mining | PubMed |
1 to 10 of 2,359
See all 2,359 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10714
GET https://conductscience.org/api/genes/v1/10714/patents?page=2