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Gene · 10714

POLD3: DNA polymerase delta 3, accessory subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POLD3: DNA polymerase delta 3, accessory subunit. Genes, record 10714. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10714

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Gene

Symbol
POLD3
HGNC
Name
DNA polymerase delta 3, accessory subunit
HGNC
NCBI Gene ID
10714
NCBI Gene
HGNC ID
HGNC:20932
HGNC
Ensembl
ENSG00000077514
NCBI Gene
Aliases
IMD122, KIAA0039, P66, P68, PPP1R128
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15054DNA polymerase delta subunit 34669Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192240Q15054Espacenet
EP 4641201 A22025-10-291811Q15054Espacenet
JP 2025517969 A2025-06-121811Q15054Espacenet
JP 2025517970 A2025-06-122240Q15054Espacenet
EP 4464338 A22024-11-20334Q15054Espacenet
JP 2024123008 A2024-09-107792Q15054Espacenet
US 11680268 B22023-06-20334Q15054Espacenet
US 11446398 B22022-09-2064993Q15054Espacenet
JP 2022524081 A2022-04-27167964Q15054Espacenet
US 11078247 B22021-08-038700Q15054Espacenet

1 to 10 of 25

See all 25 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASPACYTARABINECHEMBL4297599DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
CLOFARABINECHEMBL1750DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
CYTARABINECHEMBL803DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
FLUDARABINE PHOSPHATECHEMBL1096882DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
GEMCITABINECHEMBL888DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
GEMCITABINE HYDROCHLORIDECHEMBL1637DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL
TROXACITABINECHEMBL359164DNA polymerase (alpha/delta/epsilon) inhibitorINHIBITORChEMBL

Trials4,186

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604766GEMCITABINEPHASE3ClinicalTrials.gov
NCT07604233CYTARABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07603557FLUDARABINE PHOSPHATEPHASE2ClinicalTrials.gov
NCT07602140GEMCITABINEPHASE2ClinicalTrials.gov
NCT07598318GEMCITABINEPHASE2/PHASE3ClinicalTrials.gov
NCT07588360CYTARABINEClinicalTrials.gov
NCT07583888CYTARABINEPHASE2/PHASE3ClinicalTrials.gov
NCT07579195GEMCITABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07575191GEMCITABINEPHASE1/PHASE2ClinicalTrials.gov
NCT07570849GEMCITABINEPHASE2ClinicalTrials.gov

1 to 10 of 4,186

See all 4,186 trials

NIH grants1,731

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOLD3 papersNewest fiscal year
P30AI036219Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)92025
P30CA047904Cancer Center Support Grant82025
P30AI027767UAB Center for AIDS Research (CFAR)72025
P30AI050409Center for AIDS Research at Emory University72025
P30CA016672Cancer Center Support Grant72025
P30CA036727Buffett Cancer Center Support Grant72025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
P30CA008748Cancer Center Support Grant62025
P30CA086862Cancer Center Support Grant62025
U01CA167551Colon Cancer Family Registry Cohort62025

1 to 10 of 1,731Source NIH's project files

See all 1,731 nih grants

Papers2,359

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Western Blot Band Profiles and Their Associations with Demographic Characteristics, Transmission Routes, and Immune Status among HIV-1 Infected Individuals in Quzhou, China (2016-2024).Curr HIV Res202642736695PubTator, text miningPubMed
R-loops in colorectal cancer: mechanisms, mapping strategies, and therapeutic opportunities.Mol Biol Rep202642593691PubTator, text miningPubMed
Tumoral switch in NUMB splicing changes essential transcription pathways and induces malignant properties in tumour cells.Genome Biol202642343463PubTator, text miningPubMed
Loss of Pol32, a subunit of DNA polymerases δ and ζ, leads to different patterns of genome stability than direct impairment of these individual polymerases.mBio202641995324PubTator, text miningPubMed
Characterization of Borrelia-Derived Extracellular Vesicles: Implications for Pathogenesis and Diagnostics.Microorganisms202641900360PubTator, text miningPubMed
Cruciform-forming AT/TA repeats are acted upon by structure-selective endonucleases and Rad51 prior to repositioning to the nuclear periphery for repair.Nucleic Acids Res202641805125PubTator, text miningPubMed
Systematic Identification of Molecular Signatures Dictating Therapeutic Effects of Clinically First-Line Chemotherapy Regimens for Human Gastric Cancer Patients Based on Organoid Model.MedComm (2020)202641782964PubTator, text miningPubMed
Meeting abstracts from the Annual Conference "Clinical Genetics of Cancer 2024".Hered Cancer Clin Pract202641781972PubTator, text miningPubMed
Transient elevation in cellular glucose uptake exacerbates pressure overload-induced cardiac hypertrophy and dysfunction.Epigenetics202641779017PubTator, text miningPubMed
Mitotic microhomology-mediated break-induced replication promotes chromoanasynthesis.Nat Commun202641775729PubTator, text miningPubMed

1 to 10 of 2,359

See all 2,359 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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