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Gene · 10716

TBR1: T-box brain transcription factor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TBR1: T-box brain transcription factor 1. Genes, record 10716. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10716

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Gene

Symbol
TBR1
HGNC
Name
T-box brain transcription factor 1
HGNC
NCBI Gene ID
10716
NCBI Gene
HGNC ID
HGNC:11590
HGNC
Ensembl
ENSG00000136535
NCBI Gene
Aliases
AUTS5, IDDAS, TBR-1, TES-56
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16650T-box brain protein 16820Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2911099Q16650Espacenet
JP 2025147176 A2025-10-0615713Q16650Espacenet
JP 2025517969 A2025-06-1211099Q16650Espacenet
JP 2025032204 A2025-03-1136973Q16650Espacenet
JP 2025028160 A2025-02-2815713Q16650Espacenet
KR 1020250010750 A2025-01-2115713Q16650Espacenet
US 12156890 B22024-12-0357Q16650Espacenet
EP 4461818 A22024-11-1336973Q16650Espacenet
JP 2024109657 A2024-08-1415552Q16650Espacenet
JP 2023540130 A2023-09-2135Q16650Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,729

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTBR1 papersNewest fiscal year
UL1TR001863Yale Clinical and Translational Science Award102025
P30CA008748Cancer Center Support Grant82025
R01MH101221Rare Mutations and Autism Spectrum Disorders82025
T32HD007470Predoctoral Training in Developmental Biology72025
R01MH113257Yale Macaque Brain Resource52025
R25MH077823Research Education for Future Physician-Scientists in Child Psychiatry52025
R35NS116843Continuous Neurogenesis in the Mammalian Hippocampus52025
R37DA023999Origin of Cortical Species-specific Distinctions52025
T32AG000222Training in the Molecular Biology of Neurodegeneration and Alzheimer's Disease52025
P30CA016672Cancer Center Support Grant42025

1 to 10 of 1,729Source NIH's project files

See all 1,729 nih grants

Papers1,692

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Reduced mechanical shear is associated with early cortical differentiation and GDNF-GFRA1/RET signalling in human brain organoids.Stem Cells Transl Med202642710856PubTator, text miningPubMed
Maternal immune activation disrupts epigenomic and functional maturation of cortical excitatory neurons.Mol Psychiatry202642686997PubTator, text miningPubMed
Composition and activity of the proteasome in human iPSC-derived neuronal model of early-stage sporadic Alzheimer's disease.bioRxiv202642395371PubTator, text miningPubMed
Managing type 1 diabetes during sustained physical activity at a diabetes camp: An adaptive prandial bolus reduction algorithm for children using automated insulin delivery.Diabet Med202642381198PubTator, text miningPubMed
Autism-associated substitutions at ASN374 disrupt forkhead box P2-mediated regulation of DNA binding by t-box brain protein 1.Int J Biol Macromol202642323999PubTator, text miningPubMed
Integrated protocol for concurrent generation of microglial and neuronal cells in human cerebral organoids.BMC Methods202642306776PubTator, text miningPubMed
[Effect of glycemic variability on the efficacy of artificial pancreas systems: A real-world study].Zhong Nan Da Xue Xue Bao Yi Xue Ban202642244283PubTator, text miningPubMed
Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain.Cell Rep202642241279PubTator, text miningPubMed
Hereditary PCOS and the environmental toxicant F-53B converge on lipid metabolic reprogramming to impair fetal brain development.Ecotoxicol Environ Saf202642208382PubTator, text miningPubMed
Long-term effectiveness of automated insulin delivery in young people with type 1 diabetes: a meta-analysis.Diabetol Metab Syndr202642185906PubTator, text miningPubMed

1 to 10 of 1,692

See all 1,692 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10716

GET https://conductscience.org/api/genes/v1/10716/patents?page=2