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Gene · 10725

NFAT5: nuclear factor of activated T cells 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NFAT5: nuclear factor of activated T cells 5. Genes, record 10725. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10725

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Gene

Symbol
NFAT5
HGNC
Name
nuclear factor of activated T cells 5
HGNC
NCBI Gene ID
10725
NCBI Gene
HGNC ID
HGNC:7774
HGNC
Ensembl
ENSG00000102908
NCBI Gene
Aliases
KIAA0827, NF-AT5, NFATL1, NFATZ, OREBP, TONEBP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O94916Nuclear factor of activated T-cells 51,5311Ensembl, GeneID, HGNC

Source UniProt

Patents53

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025172069 A2025-11-20784O94916Espacenet
EP 4650780 A22025-11-197062O94916Espacenet
EP 4640849 A22025-10-291038O94916Espacenet
EP 4641201 A22025-10-296950O94916Espacenet
JP 2025147176 A2025-10-0615359O94916Espacenet
JP 2025519096 A2025-06-241038O94916Espacenet
JP 2025517969 A2025-06-126950O94916Espacenet
JP 2025517970 A2025-06-127062O94916Espacenet
US 12247982 B22025-03-11784O94916Espacenet
JP 2025028160 A2025-02-2815359O94916Espacenet

1 to 10 of 53

See all 53 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,210

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNFAT5 papersNewest fiscal year
P30CA016056Roswell Park Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant52025
R01AI040127Signal transduction and gene induction in lymphocytes42025
U54MD012392RCMI Center for Health Disparities Research42025
UL1TR001863Yale Clinical and Translational Science Award42025
P01AI039671Costimulatory Mechanisms of Autoimmunity32025
P30DK097948The Cleveland Digestive Diseases Research Core Center (DDRCC)32025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal32025
ZIAHL001285Solute And Water Transport In Renal Epithelia32025
ZIAHL006129Computational Tools for Proteomics32025

1 to 10 of 1,210Source NIH's project files

See all 1,210 nih grants

Papers1,907

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Tonicity drives collecting duct maturation in the mammalian kidney.Nat Commun202642827133PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
Arecoline promotes oral submucous fibrosis by enhancing epithelial cell cuproptosis through PUS1-mediated pseudouridylation.3 Biotech202642523757PubTator, text miningPubMed
Circular RNA circNUP214 serves as a microRNA-31 sponge to promote the progression of myasthenia gravis through NFAT5.Front Neurol202642494400PubTator, text miningPubMed
Integrated Transcriptomic Analysis Identifies Potential Biomarkers in Castration-Resistant Prostate Cancer.World J Oncol202642490773PubTator, text miningPubMed
LINC02207 suppresses breast cancer progression by promoting cuproptosis through NFAT5 regulation.Biochim Biophys Acta Mol Basis Dis202642480769PubTator, text miningPubMed
miR-543 targets NFAT5 in diabetic foot ulcer diagnosis and endothelial protection.Arch Biochem Biophys202642480676PubTator, text miningPubMed
Tumor-driven stabilization of CD8+ T cell exhaustion and implications for cancer immunotherapy.Front Immunol202642433383PubTator, text miningPubMed
Landscape of N6-methyladenosine (m6A) methylation in porcine cells identifies candidate genes associated with porcine epidemic diarrhea virus infection.Front Microbiol202642232905PubTator, text miningPubMed
Conserved Transcriptional Circuits Regulate Cardiac Fibroblast-Mediated Fibrosis.Circ Res202642125800PubTator, text miningPubMed

1 to 10 of 1,907

See all 1,907 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10725

GET https://conductscience.org/api/genes/v1/10725/patents?page=2