Gene · 10747
MASP2: MBL associated serine protease 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MASP2: MBL associated serine protease 2. Genes, record 10747. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10747
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O00187 | Mannan-binding lectin serine protease 2 | 686 | 10 | Ensembl, GeneID, HGNC |
Source UniProt
Patents206
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4775273 A2 | 2026-07-15 | 5 | O00187 | Espacenet |
| JP 2026102616 A | 2026-06-23 | 1 | O00187 | Espacenet |
| JP 2026062897 A | 2026-04-10 | 5 | O00187 | Espacenet |
| JP 2026021601 A | 2026-02-10 | 5 | O00187 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 52511 | O00187 | Espacenet |
| JP 2025541737 A | 2025-12-23 | 1 | O00187 | Espacenet |
| EP 4659763 A2 | 2025-12-10 | 5 | O00187 | Espacenet |
| US 12486278 B2 | 2025-12-02 | 1 | O00187 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 11734 | O00187 | Espacenet |
| EP 4643878 A2 | 2025-11-05 | 39 | O00187 | Espacenet |
1 to 10 of 206
See all 206 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| NARSOPLIMAB | CHEMBL4298195 | Mannan-binding lectin serine protease 2 inhibitor | INHIBITOR |
Source ChEMBL
Trials7
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05855083 | NARSOPLIMAB | PHASE2 | ClinicalTrials.gov | |
| NCT04488081 | NARSOPLIMAB | PHASE2 | ClinicalTrials.gov | |
| NCT03608033 | NARSOPLIMAB | PHASE3 | 2025-12-09 | ClinicalTrials.gov |
| NCT03205995 | NARSOPLIMAB | PHASE3 | 2025-12-10 | ClinicalTrials.gov |
| NCT02682407 | NARSOPLIMAB | PHASE2 | ClinicalTrials.gov | |
| NCT02355782 | NARSOPLIMAB | ClinicalTrials.gov | ||
| NCT02222545 | NARSOPLIMAB | PHASE2 | 2024-08-28 | ClinicalTrials.gov |
NIH grants665
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MASP2 papers | Newest fiscal year |
|---|---|---|---|
| R01AR051749 | Complement in the Pathogenesis of Autoimmune Arthritis | 9 | 2025 |
| R01DK078244 | Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| ZIAHL006223 | The role of the intracellular complement system - the complosome - in Th1 biology | 4 | 2025 |
| P01AI116501 | Pathways Regulating Lung Transplant Tolerance | 3 | 2025 |
| P30AR073752 | Washington University Rheumatic Diseases Research Resource-based Center | 3 | 2025 |
| R01DK076690 | Complement-mediated injury of the kidney: New mechanisms and novel therapies | 3 | 2025 |
| R01DK110023 | C3 Glomerulopathy -- A Collaborative Study | 3 | 2025 |
| R01HL094601 | The Role of Ischemia Reperfusion Injury in Lung Allograft Rejection | 3 | 2025 |
| RC2DK118640 | COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository | 3 | 2025 |
1 to 10 of 665Source NIH's project files
See all 665 nih grantsPapers2,026
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Enhanced anticancer efficacy of Pa-MAP 1.9 peptide-coated silver nanostars on breast cancer cells. | Mater Today Bio | 2026 | 42701436 | PubTator, text mining | PubMed |
| Diverging Liquid-Liquid Phase Separation Behavior of Different Recombinant Major Ampullate Spidroins. | Adv Sci (Weinh) | 2026 | 42621696 | PubTator, text mining | PubMed |
| Coordinated suppression of lectin complement pathway effectors and upregulation of SERPING1 defines a thrombo-inflammatory regulatory signature in Acute Coronary disease. | Mol Biol Rep | 2026 | 42606632 | PubTator, text mining | PubMed |
| The Circulating Cholangiocarcinoma Protein Biomarkers CRP and MASP2 Also Predict Gallbladder Cancer Risk. | Int J Cancer | 2026 | 42473323 | PubTator, text mining | PubMed |
| Complement-targeted therapies for transplant-associated thrombotic microangiopathy: recent advances. | Front Pharmacol | 2026 | 42371577 | PubTator, text mining | PubMed |
| Common and rare variants in complement genes as biomarkers of COVID-19 infection and severity. A lesson to learn for emerging pathogens. | Front Immunol | 2026 | 42367796 | PubTator, text mining | PubMed |
| Design, Synthesis, Biological Evaluation, and Molecular Docking of Novel Thiazolyl-Pyrazoline Derivatives as Potential EGFR Inhibitors. | Chem Biol Drug Des | 2026 | 42338155 | PubTator, text mining | PubMed |
| Efficacy of skin microvasculature C5b-9 and MASP2 deposition in transplant-associated thrombotic microangiopathy. | Leuk Lymphoma | 2026 | 42302251 | PubTator, text mining | PubMed |
| Small Molecule Activators of Protein Phosphatase 2A Exert Global Stabilizing Effects on the Scaffold PR65. | JACS Au | 2026 | 42212067 | PubTator, text mining | PubMed |
| Narsoplimab: First Approval. | Drugs | 2026 | 42144536 | PubTator, text mining | PubMed |
1 to 10 of 2,026
See all 2,026 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10747
GET https://conductscience.org/api/genes/v1/10747/patents?page=2