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Gene · 10747

MASP2: MBL associated serine protease 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MASP2: MBL associated serine protease 2. Genes, record 10747. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10747

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Gene

Symbol
MASP2
HGNC
Name
MBL associated serine protease 2
HGNC
NCBI Gene ID
10747
NCBI Gene
HGNC ID
HGNC:6902
HGNC
Ensembl
ENSG00000009724
NCBI Gene
Aliases
MAP-2, MAP19, MASP-2, MASP1P1, Map19, sMAP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00187Mannan-binding lectin serine protease 268610Ensembl, GeneID, HGNC

Source UniProt

Patents206

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4775273 A22026-07-155O00187Espacenet
JP 2026102616 A2026-06-231O00187Espacenet
JP 2026062897 A2026-04-105O00187Espacenet
JP 2026021601 A2026-02-105O00187Espacenet
JP 2026004568 A2026-01-1452511O00187Espacenet
JP 2025541737 A2025-12-231O00187Espacenet
EP 4659763 A22025-12-105O00187Espacenet
US 12486278 B22025-12-021O00187Espacenet
EP 4650780 A22025-11-1911734O00187Espacenet
EP 4643878 A22025-11-0539O00187Espacenet

1 to 10 of 206

See all 206 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
NARSOPLIMABCHEMBL4298195Mannan-binding lectin serine protease 2 inhibitorINHIBITOR

Source ChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05855083NARSOPLIMABPHASE2ClinicalTrials.gov
NCT04488081NARSOPLIMABPHASE2ClinicalTrials.gov
NCT03608033NARSOPLIMABPHASE32025-12-09ClinicalTrials.gov
NCT03205995NARSOPLIMABPHASE32025-12-10ClinicalTrials.gov
NCT02682407NARSOPLIMABPHASE2ClinicalTrials.gov
NCT02355782NARSOPLIMABClinicalTrials.gov
NCT02222545NARSOPLIMABPHASE22024-08-28ClinicalTrials.gov

NIH grants665

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMASP2 papersNewest fiscal year
R01AR051749Complement in the Pathogenesis of Autoimmune Arthritis92025
R01DK078244Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes52025
P30CA008748Cancer Center Support Grant42025
ZIAHL006223The role of the intracellular complement system - the complosome - in Th1 biology42025
P01AI116501Pathways Regulating Lung Transplant Tolerance32025
P30AR073752Washington University Rheumatic Diseases Research Resource-based Center32025
R01DK076690Complement-mediated injury of the kidney: New mechanisms and novel therapies32025
R01DK110023C3 Glomerulopathy -- A Collaborative Study32025
R01HL094601The Role of Ischemia Reperfusion Injury in Lung Allograft Rejection32025
RC2DK118640COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepository32025

1 to 10 of 665Source NIH's project files

See all 665 nih grants

Papers2,026

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Enhanced anticancer efficacy of Pa-MAP 1.9 peptide-coated silver nanostars on breast cancer cells.Mater Today Bio202642701436PubTator, text miningPubMed
Diverging Liquid-Liquid Phase Separation Behavior of Different Recombinant Major Ampullate Spidroins.Adv Sci (Weinh)202642621696PubTator, text miningPubMed
Coordinated suppression of lectin complement pathway effectors and upregulation of SERPING1 defines a thrombo-inflammatory regulatory signature in Acute Coronary disease.Mol Biol Rep202642606632PubTator, text miningPubMed
The Circulating Cholangiocarcinoma Protein Biomarkers CRP and MASP2 Also Predict Gallbladder Cancer Risk.Int J Cancer202642473323PubTator, text miningPubMed
Complement-targeted therapies for transplant-associated thrombotic microangiopathy: recent advances.Front Pharmacol202642371577PubTator, text miningPubMed
Common and rare variants in complement genes as biomarkers of COVID-19 infection and severity. A lesson to learn for emerging pathogens.Front Immunol202642367796PubTator, text miningPubMed
Design, Synthesis, Biological Evaluation, and Molecular Docking of Novel Thiazolyl-Pyrazoline Derivatives as Potential EGFR Inhibitors.Chem Biol Drug Des202642338155PubTator, text miningPubMed
Efficacy of skin microvasculature C5b-9 and MASP2 deposition in transplant-associated thrombotic microangiopathy.Leuk Lymphoma202642302251PubTator, text miningPubMed
Small Molecule Activators of Protein Phosphatase 2A Exert Global Stabilizing Effects on the Scaffold PR65.JACS Au202642212067PubTator, text miningPubMed
Narsoplimab: First Approval.Drugs202642144536PubTator, text miningPubMed

1 to 10 of 2,026

See all 2,026 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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