Gene · 1075
CTSC: cathepsin C
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CTSC: cathepsin C. Genes, record 1075. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1075
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P53634 | Dipeptidyl peptidase 1 | 463 | 18 | Ensembl, GeneID, HGNC |
Source UniProt
Patents39
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| US 12539325 B2 | 2026-02-03 | 34 | P53634 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 40321 | P53634 | Espacenet |
| JP 2025172069 A | 2025-11-20 | 192 | P53634 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 676 | P53634 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 473 | P53634 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 3728 | P53634 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6054 | P53634 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6054 | P53634 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 473 | P53634 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 676 | P53634 | Espacenet |
1 to 10 of 39
See all 39 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| BRENSOCATIB | CHEMBL3900409 | Dipeptidyl peptidase I inhibitor | INHIBITOR |
Source ChEMBL
Trials7
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06685835 | BRENSOCATIB | PHASE2 | ClinicalTrials.gov | |
| NCT06013241 | BRENSOCATIB | PHASE2 | ClinicalTrials.gov | |
| NCT05344508 | BRENSOCATIB | ClinicalTrials.gov | ||
| NCT05090904 | BRENSOCATIB | PHASE2 | 2026-03-12 | ClinicalTrials.gov |
| NCT04817332 | BRENSOCATIB | PHASE3 | 2023-08-22 | ClinicalTrials.gov |
| NCT04594369 | BRENSOCATIB | PHASE3 | 2025-12-16 | ClinicalTrials.gov |
| NCT03218917 | BRENSOCATIB | PHASE2 | 2023-02-08 | ClinicalTrials.gov |
NIH grants1,493
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CTSC papers | Newest fiscal year |
|---|---|---|---|
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30DK078392 | Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease | 5 | 2025 |
| ZIAAR041199 | Systemic Autoimmunity | 4 | 2025 |
| P20GM121176 | Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2. | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 3 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 3 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 3 | 2025 |
| R35GM119840 | Chemical biology approaches to probe signaling by protein lipidation | 3 | 2025 |
1 to 10 of 1,493Source NIH's project files
See all 1,493 nih grantsPapers2,597
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Phase III AIRTIVITY study design: verducatib (BI 1291583) in people with bronchiectasis. | ERJ Open Res | 2026 | 42820152 | PubTator, text mining | PubMed |
| Sputum cathepsin G activity predicts exacerbations and hospitalisations in bronchiectasis. | ERJ Open Res | 2026 | 42807352 | PubTator, text mining | PubMed |
| Brensocatib in non-cystic fibrosis bronchiectasis: neutrophil serine protease modulation, clinical evidence, and therapeutic positioning. | Expert Rev Clin Pharmacol | 2026 | 42788768 | PubTator, text mining | PubMed |
| Medical issues and pulmonary outcomes in cystic fibrosis and bronchiectasis. | Curr Opin Pulm Med | 2026 | 42755280 | PubTator, text mining | PubMed |
| Composition and Function of Decellularized Human Lung Extracellular Matrix from Congenital Pulmonary Airway Malformation. | J Clin Med | 2026 | 42739747 | PubTator, text mining | PubMed |
| Machine learning-assisted plasma PEA proteomics enables differential diagnosis of melancholic depression and bipolar disorder. | J Affect Disord | 2026 | 42716347 | PubTator, text mining | PubMed |
| Population Pharmacokinetic Analysis of Brensocatib in Adult and Adolescent Patients With Non-Cystic Fibrosis Bronchiectasis. | CPT Pharmacometrics Syst Pharmacol | 2026 | 42712175 | PubTator, text mining | PubMed |
| Multi-omics Mendelian Randomization Prioritizes Neutrophil Extracellular Trap-related Genes Associated with Atrial Fibrillation Risk. | Endocr Metab Immune Disord Drug Targets | 2026 | 42693724 | PubTator, text mining | PubMed |
| Florensocatib in adults with bronchiectasis: the HOPE-BE trial protocol and baseline demographic characteristics. | ERJ Open Res | 2026 | 42639008 | PubTator, text mining | PubMed |
| Impact of KCl-divalent salt synergistic substitution on protease activity and volatile flavor profile in sodium-reduced sour meat. | Food Chem X | 2026 | 42620897 | PubTator, text mining | PubMed |
1 to 10 of 2,597
See all 2,597 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1075
GET https://conductscience.org/api/genes/v1/1075/patents?page=2