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Gene · 1075

CTSC: cathepsin C

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CTSC: cathepsin C. Genes, record 1075. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1075

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Gene

Symbol
CTSC
HGNC
Name
cathepsin C
HGNC
NCBI Gene ID
1075
NCBI Gene
HGNC ID
HGNC:2528
HGNC
Ensembl
ENSG00000109861
NCBI Gene
Aliases
CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P53634Dipeptidyl peptidase 146318Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0334P53634Espacenet
JP 2026004568 A2026-01-1440321P53634Espacenet
JP 2025172069 A2025-11-20192P53634Espacenet
EP 4650780 A22025-11-19676P53634Espacenet
EP 4641201 A22025-10-29473P53634Espacenet
JP 2025147176 A2025-10-063728P53634Espacenet
JP 2025529142 A2025-09-046054P53634Espacenet
US 12371689 B22025-07-296054P53634Espacenet
JP 2025517969 A2025-06-12473P53634Espacenet
JP 2025517970 A2025-06-12676P53634Espacenet

1 to 10 of 39

See all 39 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
BRENSOCATIBCHEMBL3900409Dipeptidyl peptidase I inhibitorINHIBITOR

Source ChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06685835BRENSOCATIBPHASE2ClinicalTrials.gov
NCT06013241BRENSOCATIBPHASE2ClinicalTrials.gov
NCT05344508BRENSOCATIBClinicalTrials.gov
NCT05090904BRENSOCATIBPHASE22026-03-12ClinicalTrials.gov
NCT04817332BRENSOCATIBPHASE32023-08-22ClinicalTrials.gov
NCT04594369BRENSOCATIBPHASE32025-12-16ClinicalTrials.gov
NCT03218917BRENSOCATIBPHASE22023-02-08ClinicalTrials.gov

NIH grants1,493

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCTSC papersNewest fiscal year
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions52025
P30CA008748Cancer Center Support Grant52025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease52025
ZIAAR041199Systemic Autoimmunity42025
P20GM121176Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.32025
P30CA016672Cancer Center Support Grant32025
P30CA044579University of Virginia Cancer Center Support Grant32025
P30DK034854Integrated Epithelial and Muscosal Biology32025
P30ES013508Center of Excellence in Environmental Toxicology32025
R35GM119840Chemical biology approaches to probe signaling by protein lipidation32025

1 to 10 of 1,493Source NIH's project files

See all 1,493 nih grants

Papers2,597

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Phase III AIRTIVITY study design: verducatib (BI 1291583) in people with bronchiectasis.ERJ Open Res202642820152PubTator, text miningPubMed
Sputum cathepsin G activity predicts exacerbations and hospitalisations in bronchiectasis.ERJ Open Res202642807352PubTator, text miningPubMed
Brensocatib in non-cystic fibrosis bronchiectasis: neutrophil serine protease modulation, clinical evidence, and therapeutic positioning.Expert Rev Clin Pharmacol202642788768PubTator, text miningPubMed
Medical issues and pulmonary outcomes in cystic fibrosis and bronchiectasis.Curr Opin Pulm Med202642755280PubTator, text miningPubMed
Composition and Function of Decellularized Human Lung Extracellular Matrix from Congenital Pulmonary Airway Malformation.J Clin Med202642739747PubTator, text miningPubMed
Machine learning-assisted plasma PEA proteomics enables differential diagnosis of melancholic depression and bipolar disorder.J Affect Disord202642716347PubTator, text miningPubMed
Population Pharmacokinetic Analysis of Brensocatib in Adult and Adolescent Patients With Non-Cystic Fibrosis Bronchiectasis.CPT Pharmacometrics Syst Pharmacol202642712175PubTator, text miningPubMed
Multi-omics Mendelian Randomization Prioritizes Neutrophil Extracellular Trap-related Genes Associated with Atrial Fibrillation Risk.Endocr Metab Immune Disord Drug Targets202642693724PubTator, text miningPubMed
Florensocatib in adults with bronchiectasis: the HOPE-BE trial protocol and baseline demographic characteristics.ERJ Open Res202642639008PubTator, text miningPubMed
Impact of KCl-divalent salt synergistic substitution on protease activity and volatile flavor profile in sodium-reduced sour meat.Food Chem X202642620897PubTator, text miningPubMed

1 to 10 of 2,597

See all 2,597 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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