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Gene · 10765

KDM5B: lysine demethylase 5B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KDM5B: lysine demethylase 5B. Genes, record 10765. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10765

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Gene

Symbol
KDM5B
HGNC
Name
lysine demethylase 5B
HGNC
NCBI Gene ID
10765
NCBI Gene
HGNC ID
HGNC:18039
HGNC
Ensembl
ENSG00000117139
NCBI Gene
Aliases
CT31, JARID1B, MRT65, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A, RBP2-H1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UGL1Lysine-specific demethylase 5B1,54456Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452091Q9UGL1Espacenet
EP 4641201 A22025-10-298362Q9UGL1Espacenet
JP 2025147176 A2025-10-0615202Q9UGL1Espacenet
JP 2025517969 A2025-06-128362Q9UGL1Espacenet
JP 2025028160 A2025-02-2815202Q9UGL1Espacenet
KR 1020250010750 A2025-01-2115202Q9UGL1Espacenet
KR 1020240156643 A2024-10-30351Q9UGL1Espacenet
JP 2024109657 A2024-08-1415041Q9UGL1Espacenet
US 11628211 B22023-04-18351Q9UGL1Espacenet
JP 2023051941 A2023-04-11351Q9UGL1Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,590

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKDM5B papersNewest fiscal year
P30CA010815Consolidated Basic Cancer Research Program162025
P30CA016672Cancer Center Support Grant132025
P50CA121974Yale SPORE in Skin Cancer122025
P30CA016359Cancer Center Support Grant112025
P30CA008748Cancer Center Support Grant82025
P30CA016087Cancer Center Support Grant82025
P30CA013330Cancer Center Support Grant72025
R35GM119728Quantifying the coordinated dynamics of single-gene transcription and translation in living cells72025
R01CA198279Shaping DNA Damage Response Networks Via Histone H2A Variants62025
R35GM124747Integrating Multi-Scale Imaging, Reaction-Diffusion Simulation, and Markov Model Inference to Enhance Predictive Design and Interpretation of Single-Molecule Gene Regulation Experiments62025

1 to 10 of 1,590Source NIH's project files

See all 1,590 nih grants

Papers2,218

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Lysine specific demethylase 5B promises to be a new focus of cancer drug-resistance: combination therapy.Biochim Biophys Acta Rev Cancer202642815836PubTator, text miningPubMed
Identification and mechanistic investigation of novel biomarkers for diabetic retinopathy through hypoxia- and cuproptosis-associated gene analysis.PLoS One202642789564PubTator, text miningPubMed
Cancer Stem Cell Quiescence: Molecular and Microenvironmental Evidence for an Actively Regulated Adaptive Survival Strategy.Cancer Med202642768738PubTator, text miningPubMed
PROFET predicts continuous gene expression dynamics from scRNA-seq data to elucidate heterogeneity of cancer treatment responses.Cell Syst202642664975PubTator, text miningPubMed
Tumor-intrinsic PHGDH inhibition sensitizes colorectal cancer to PD-1 blockade via α-ketoglutarate-mediated macrophage reprogramming.Drug Resist Updat202642624032PubTator, text miningPubMed
Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis.Mol Biomed202642554966PubTator, text miningPubMed
Nanog promotes proliferation, migration, and invasion of gastric cancer cells via regulation of the KDM5B/H3K4me3 epigenetic axis.Adv Clin Exp Med202642524820PubTator, text miningPubMed
Lactylation Orchestrates Immune Evasion in Gastric Cancer through KDM5B-Mediated Histone Demethylation.Cancer Res202642489575PubTator, text miningPubMed
miR-770-5p regulates KDM5B and links its nuclear localization to HER2 signaling in trastuzumab-resistant breast cancer.Mol Cell Biochem202642474975PubTator, text miningPubMed
microRNA-139-3p Inhibits Malignant Behaviors of Laryngeal Cancer Cells via the KDM5B/SOX2 Axis and the Wnt/β-Catenin Pathway [Retraction].Cancer Manag Res202642453698PubTator, text miningPubMed

1 to 10 of 2,218

See all 2,218 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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