Gene · 10765
KDM5B: lysine demethylase 5B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. KDM5B: lysine demethylase 5B. Genes, record 10765. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10765
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UGL1 | Lysine-specific demethylase 5B | 1,544 | 56 | Ensembl, GeneID, HGNC |
Source UniProt
Patents33
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 52091 | Q9UGL1 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8362 | Q9UGL1 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15202 | Q9UGL1 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8362 | Q9UGL1 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15202 | Q9UGL1 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15202 | Q9UGL1 | Espacenet |
| KR 1020240156643 A | 2024-10-30 | 351 | Q9UGL1 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15041 | Q9UGL1 | Espacenet |
| US 11628211 B2 | 2023-04-18 | 351 | Q9UGL1 | Espacenet |
| JP 2023051941 A | 2023-04-11 | 351 | Q9UGL1 | Espacenet |
1 to 10 of 33
See all 33 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,590
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | KDM5B papers | Newest fiscal year |
|---|---|---|---|
| P30CA010815 | Consolidated Basic Cancer Research Program | 16 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 13 | 2025 |
| P50CA121974 | Yale SPORE in Skin Cancer | 12 | 2025 |
| P30CA016359 | Cancer Center Support Grant | 11 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 8 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 7 | 2025 |
| R35GM119728 | Quantifying the coordinated dynamics of single-gene transcription and translation in living cells | 7 | 2025 |
| R01CA198279 | Shaping DNA Damage Response Networks Via Histone H2A Variants | 6 | 2025 |
| R35GM124747 | Integrating Multi-Scale Imaging, Reaction-Diffusion Simulation, and Markov Model Inference to Enhance Predictive Design and Interpretation of Single-Molecule Gene Regulation Experiments | 6 | 2025 |
1 to 10 of 1,590Source NIH's project files
See all 1,590 nih grantsPapers2,218
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Lysine specific demethylase 5B promises to be a new focus of cancer drug-resistance: combination therapy. | Biochim Biophys Acta Rev Cancer | 2026 | 42815836 | PubTator, text mining | PubMed |
| Identification and mechanistic investigation of novel biomarkers for diabetic retinopathy through hypoxia- and cuproptosis-associated gene analysis. | PLoS One | 2026 | 42789564 | PubTator, text mining | PubMed |
| Cancer Stem Cell Quiescence: Molecular and Microenvironmental Evidence for an Actively Regulated Adaptive Survival Strategy. | Cancer Med | 2026 | 42768738 | PubTator, text mining | PubMed |
| PROFET predicts continuous gene expression dynamics from scRNA-seq data to elucidate heterogeneity of cancer treatment responses. | Cell Syst | 2026 | 42664975 | PubTator, text mining | PubMed |
| Tumor-intrinsic PHGDH inhibition sensitizes colorectal cancer to PD-1 blockade via α-ketoglutarate-mediated macrophage reprogramming. | Drug Resist Updat | 2026 | 42624032 | PubTator, text mining | PubMed |
| Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis. | Mol Biomed | 2026 | 42554966 | PubTator, text mining | PubMed |
| Nanog promotes proliferation, migration, and invasion of gastric cancer cells via regulation of the KDM5B/H3K4me3 epigenetic axis. | Adv Clin Exp Med | 2026 | 42524820 | PubTator, text mining | PubMed |
| Lactylation Orchestrates Immune Evasion in Gastric Cancer through KDM5B-Mediated Histone Demethylation. | Cancer Res | 2026 | 42489575 | PubTator, text mining | PubMed |
| miR-770-5p regulates KDM5B and links its nuclear localization to HER2 signaling in trastuzumab-resistant breast cancer. | Mol Cell Biochem | 2026 | 42474975 | PubTator, text mining | PubMed |
| microRNA-139-3p Inhibits Malignant Behaviors of Laryngeal Cancer Cells via the KDM5B/SOX2 Axis and the Wnt/β-Catenin Pathway [Retraction]. | Cancer Manag Res | 2026 | 42453698 | PubTator, text mining | PubMed |
1 to 10 of 2,218
See all 2,218 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10765
GET https://conductscience.org/api/genes/v1/10765/patents?page=2