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CFTR: CF transmembrane conductance regulator

1 protein, 126 patents, 14 drugs, 330 trials, 8,581 NIH grants and 26,004 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCFTRHGNC
NameCF transmembrane conductance regulatorHGNC
NCBI Gene ID1080NCBI Gene
HGNC IDHGNC:1884HGNC
EnsemblENSG00000001626NCBI Gene
AliasesABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P13569Cystic fibrosis transmembrane conductance regulator1,48058Ensembl, GeneID, HGNCUniProt

Patents 126

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4777830 A12026-07-227P13569Espacenet
EP 4774294 A12026-07-1527P13569Espacenet
EP 4774397 A12026-07-15103P13569Espacenet
JP 2026518827 A2026-06-1019P13569Espacenet
EP 4731186 A22026-04-2914P13569Espacenet
US 12594295 B22026-04-071P13569Espacenet
JP 2026509462 A2026-03-19258P13569Espacenet
EP 4689118 A12026-02-1119P13569Espacenet
EP 4658322 A12025-12-10751P13569Espacenet
EP 4658781 A22025-12-102598P13569Espacenet

Drugs 14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BAMOCAFTORCHEMBL4297849Cystic fibrosis transmembrane conductance regulator positive modulatorPOSITIVE MODULATORChEMBL
CROFELEMERCHEMBL2108184Cystic fibrosis transmembrane conductance regulator inhibitorINHIBITORChEMBL
DEUTIVACAFTORCHEMBL4297603Cystic fibrosis transmembrane conductance regulator activatorACTIVATORChEMBL
ELEXACAFTORCHEMBL4298128Cystic fibrosis transmembrane conductance regulator positive modulatorPOSITIVE MODULATORChEMBL
GALICAFTORCHEMBL4101487Cystic fibrosis transmembrane conductance regulator positive modulatorPOSITIVE MODULATORChEMBL
ICENTICAFTORCHEMBL4650318Cystic fibrosis transmembrane conductance regulator activatorACTIVATORChEMBL
IOWH-032CHEMBL4297392Cystic fibrosis transmembrane conductance regulator inhibitorINHIBITORChEMBL
IVACAFTORCHEMBL2010601Cystic fibrosis transmembrane conductance regulator activatorACTIVATORChEMBL
IVACAFTORCHEMBL2010601Cystic fibrosis transmembrane conductance regulator positive modulatorPOSITIVE MODULATORChEMBL
LUMACAFTORCHEMBL2103870Cystic fibrosis transmembrane conductance regulator stabiliserSTABILISERChEMBL

Trials 330

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07363304IVACAFTORClinicalTrials.gov
NCT07363304TEZACAFTORClinicalTrials.gov
NCT07363304ELEXACAFTORClinicalTrials.gov
NCT07148739IVACAFTORPHASE4ClinicalTrials.gov
NCT07148739TEZACAFTORPHASE4ClinicalTrials.gov
NCT07148739ELEXACAFTORPHASE4ClinicalTrials.gov
NCT07022327IVACAFTORClinicalTrials.gov
NCT06904872CROFELEMERPHASE2ClinicalTrials.gov
NCT06721871CROFELEMERPHASE2/PHASE3ClinicalTrials.gov
NCT06460506IVACAFTORPHASE3ClinicalTrials.gov

NIH grants 8581

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK072482UAB CF Research and Translation Core Center2312,025NIH's project files
P30DK054759Precision Medicine Center for Cystic Fibrosis2062,025NIH's project files
P30DK089507Center for Cystic Fibrosis Translational Research in the Post-CFTR modulator Era1712,025NIH's project files
P30DK065988UNC Cystic Fibrosis Research and Translation Core Center1232,025NIH's project files
P30ES005605Environmental Health Sciences Research Center942,025NIH's project files
R01DK044003Molecular Genetics of Cystic Fibrosis602,025NIH's project files
P30DK034989Yale Liver Center412,025NIH's project files
R01DK080834Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea382,025NIH's project files
U01DK108334INSPPIRE: Using the natural history of pediatric chronic pancreatitis to identify disease predictors and design therapies382,025NIH's project files
P30DK117469DartCF: The Dartmouth Cystic Fibrosis Research Center352,025NIH's project files

Papers 26004

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826236PubTator, text miningPubMed
42825108PubTator, text miningPubMed
42824283PubTator, text miningPubMed
42819878PubTator, text miningPubMed
42819752PubTator, text miningPubMed
42815627PubTator, text miningPubMed
42813179PubTator, text miningPubMed
42803148PubTator, text miningPubMed
42796053PubTator, text miningPubMed
42795633PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license