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Gene · 10804

GJB6: gap junction protein beta 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GJB6: gap junction protein beta 6. Genes, record 10804. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10804

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Gene

Symbol
GJB6
HGNC
Name
gap junction protein beta 6
HGNC
NCBI Gene ID
10804
NCBI Gene
HGNC ID
HGNC:4288
HGNC
Ensembl
ENSG00000121742
NCBI Gene
Aliases
CX30, DFNA3, DFNA3B, DFNB1B, ECTD2, ED2, EDH, HED, HED2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95452Gap junction beta-6 protein2610Ensembl, GeneID, HGNC

Source UniProt

Patents74

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082974 A2026-05-19125O95452Espacenet
JP 2026004568 A2026-01-1447362O95452Espacenet
JP 2026004568 A2026-01-1447363O95452Espacenet
JP 2026004568 A2026-01-1447364O95452Espacenet
JP 2026004568 A2026-01-1447365O95452Espacenet
EP 4641202 A22025-10-2938O95452Espacenet
JP 2025529142 A2025-09-041723O95452Espacenet
US 12371689 B22025-07-291723O95452Espacenet
JP 2025032204 A2025-03-1129012O95452Espacenet
JP 2025032204 A2025-03-1129013O95452Espacenet

1 to 10 of 74

See all 74 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants920

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGJB6 papersNewest fiscal year
R01DC012049Optimizing Genetic Testing for Deafness for Clinical Diagnostics92025
R01DC003594Identification of Autosomal Recessive Nonsyndromic Hearing Impairment Genes82025
R01DC009645A Collaborative Search for New Genes for Non-Syndromic Deafness82025
R01GM099490Gating and Regulation of Connexin Hemichannels62025
R01DK064324Multiphoton imaging of the juxtaglomerular apparatus52025
ZIADE000695Adeno-associated Virus Biology And Utilization For Gene Transfer42025
P30CA013330Cancer Center Support Grant32025
P30EY008126Core Grant in Vision Research32025
P30CA047904Cancer Center Support Grant22025
P30CA068485Cancer Center Support Grant22025

1 to 10 of 920Source NIH's project files

See all 920 nih grants

Papers2,004

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Spatio-Temporal Expression Patterns of Connexins 43 and 30 in Hippocampal Astrocytes During Postnatal Development.Int J Mol Sci202642794472PubTator, text miningPubMed
Clinical and Genetic Characterization of Gap Junction Protein β-6 Variants in Non-Syndromic Hearing Loss: A Case Report with Familial Evaluation and In Silico Analyses.Iran J Med Sci202642764838PubTator, text miningPubMed
[Advances in research on the molecular mechanisms and gene therapy of hereditary hearing impairment].Zhonghua Yu Fang Yi Xue Za Zhi202642503939PubTator, text miningPubMed
Mitochondrial tRNAGly A10055G mutation contributes to non-syndromic hearing loss: a study of three Han Chinese pedigrees.Mitochondrial DNA A DNA Mapp Seq Anal202642489722PubTator, text miningPubMed
Connexins in metabolic control: linking brain cellular communication to systemic homeostasis.Life Med202642483490PubTator, text miningPubMed
Connexins in the nucleus: A review of emerging roles in cell signaling and gene regulation.Int J Biol Macromol202642476243PubTator, text miningPubMed
Genetic Diagnosis of Non-Syndromic Hearing Loss in South Indian Consanguineous Families Using Whole-Exome Sequencing.Medicina (Kaunas)202642356053PubTator, text miningPubMed
Calcium-modulated GJB6-GRHL3 positive feedback loop attenuates ESCC progression through AKT signaling pathway inhibition.NPJ Precis Oncol202642243308PubTator, text miningPubMed
Genetic Landscape of Hearing Loss in Brazilian Patients Reveals Population-Specific Variants and Clinical Correlations.Clin Genet202642233699PubTator, text miningPubMed
Connexin hemichannels as therapeutic targets in glioblastoma.Cancer Lett202642229825PubTator, text miningPubMed

1 to 10 of 2,004

See all 2,004 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10804

GET https://conductscience.org/api/genes/v1/10804/patents?page=2