Gene · 10804
GJB6: gap junction protein beta 6
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GJB6: gap junction protein beta 6. Genes, record 10804. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10804
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95452 | Gap junction beta-6 protein | 261 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents74
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026082974 A | 2026-05-19 | 125 | O95452 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47362 | O95452 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47363 | O95452 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47364 | O95452 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47365 | O95452 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 38 | O95452 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1723 | O95452 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1723 | O95452 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29012 | O95452 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29013 | O95452 | Espacenet |
1 to 10 of 74
See all 74 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants920
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GJB6 papers | Newest fiscal year |
|---|---|---|---|
| R01DC012049 | Optimizing Genetic Testing for Deafness for Clinical Diagnostics | 9 | 2025 |
| R01DC003594 | Identification of Autosomal Recessive Nonsyndromic Hearing Impairment Genes | 8 | 2025 |
| R01DC009645 | A Collaborative Search for New Genes for Non-Syndromic Deafness | 8 | 2025 |
| R01GM099490 | Gating and Regulation of Connexin Hemichannels | 6 | 2025 |
| R01DK064324 | Multiphoton imaging of the juxtaglomerular apparatus | 5 | 2025 |
| ZIADE000695 | Adeno-associated Virus Biology And Utilization For Gene Transfer | 4 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 3 | 2025 |
| P30EY008126 | Core Grant in Vision Research | 3 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 2 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 920Source NIH's project files
See all 920 nih grantsPapers2,004
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Spatio-Temporal Expression Patterns of Connexins 43 and 30 in Hippocampal Astrocytes During Postnatal Development. | Int J Mol Sci | 2026 | 42794472 | PubTator, text mining | PubMed |
| Clinical and Genetic Characterization of Gap Junction Protein β-6 Variants in Non-Syndromic Hearing Loss: A Case Report with Familial Evaluation and In Silico Analyses. | Iran J Med Sci | 2026 | 42764838 | PubTator, text mining | PubMed |
| [Advances in research on the molecular mechanisms and gene therapy of hereditary hearing impairment]. | Zhonghua Yu Fang Yi Xue Za Zhi | 2026 | 42503939 | PubTator, text mining | PubMed |
| Mitochondrial tRNAGly A10055G mutation contributes to non-syndromic hearing loss: a study of three Han Chinese pedigrees. | Mitochondrial DNA A DNA Mapp Seq Anal | 2026 | 42489722 | PubTator, text mining | PubMed |
| Connexins in metabolic control: linking brain cellular communication to systemic homeostasis. | Life Med | 2026 | 42483490 | PubTator, text mining | PubMed |
| Connexins in the nucleus: A review of emerging roles in cell signaling and gene regulation. | Int J Biol Macromol | 2026 | 42476243 | PubTator, text mining | PubMed |
| Genetic Diagnosis of Non-Syndromic Hearing Loss in South Indian Consanguineous Families Using Whole-Exome Sequencing. | Medicina (Kaunas) | 2026 | 42356053 | PubTator, text mining | PubMed |
| Calcium-modulated GJB6-GRHL3 positive feedback loop attenuates ESCC progression through AKT signaling pathway inhibition. | NPJ Precis Oncol | 2026 | 42243308 | PubTator, text mining | PubMed |
| Genetic Landscape of Hearing Loss in Brazilian Patients Reveals Population-Specific Variants and Clinical Correlations. | Clin Genet | 2026 | 42233699 | PubTator, text mining | PubMed |
| Connexin hemichannels as therapeutic targets in glioblastoma. | Cancer Lett | 2026 | 42229825 | PubTator, text mining | PubMed |
1 to 10 of 2,004
See all 2,004 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10804
GET https://conductscience.org/api/genes/v1/10804/patents?page=2