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Gene · 10818

FRS2: fibroblast growth factor receptor substrate 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FRS2: fibroblast growth factor receptor substrate 2. Genes, record 10818. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10818

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Gene

Symbol
FRS2
HGNC
Name
fibroblast growth factor receptor substrate 2
HGNC
NCBI Gene ID
10818
NCBI Gene
HGNC ID
HGNC:16971
HGNC
Ensembl
ENSG00000166225
NCBI Gene
Aliases
FRS1A, FRS2A, FRS2alpha, SNT, SNT-1, SNT1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8WU20Fibroblast growth factor receptor substrate 25082Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1911554Q8WU20Espacenet
JP 2025517970 A2025-06-1211554Q8WU20Espacenet
JP 2023123507 A2023-09-05136Q8WU20Espacenet
JP 2022541456 A2022-09-2611Q8WU20Espacenet
US 11446398 B22022-09-2031968Q8WU20Espacenet
US 11446398 B22022-09-2031970Q8WU20Espacenet
US 11446398 B22022-09-2031978Q8WU20Espacenet
JP 2022537339 A2022-08-255Q8WU20Espacenet
KR 1020220075306 A2022-06-085Q8WU20Espacenet
US 11326167 B22022-05-1023Q8WU20Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,029

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFRS2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant252025
P30CA008748Cancer Center Support Grant152025
P30CA068485Cancer Center Support Grant82025
P30CA021765Cancer Center Support Grant (CCSG)52025
P30CA046934University of Colorado Cancer Center Support Grant52025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant42025
R01EY017061Signaling Mechanisms of Lens Development42025
K12CA090628Paul Calabresi Program in Clinical/Translational Research at Mayo Clinic32025
P30CA013148Comprehensive Cancer Center Support Grant32025
P30CA016058Cancer Center Support Grant32025

1 to 10 of 1,029Source NIH's project files

See all 1,029 nih grants

Papers1,537

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Correction: Mechanistic insights into cannabidiol-mediated TrkB activation via FRS2 interaction in attenuating Alzheimer's disease pathology and cognitive impairment.Mol Psychiatry202642687000PubTator, text miningPubMed
Tanshinone IIA attenuates myocardial ischemia by targeting FGFR1 residue Gln284 for allosteric modulation and subsequent autophagy inhibition.Phytomedicine202642542063PubTator, text miningPubMed
AI-Driven discovery and experimental validation of covalent FGFR4 inhibitors for hepatocellular carcinoma.J Transl Med202642482266PubTator, text miningPubMed
Fibroblast growth factor receptor substrate 2 interactome mapping reveals novel candidate interactors associated with migration and invasion.Cell Commun Signal202642169144PubTator, text miningPubMed
Selection and Optimization of a High-Affinity FGFR4 Aptamer that Blocks FGF19-FGFR4 Signaling.Anal Chem202642159546PubTator, text miningPubMed
Fibroblast growth factor 10 attenuates advanced liver fibrosis through hepatocyte fibroblast growth factor receptor 2 signalling.Clin Transl Med202642117407PubTator, text miningPubMed
Novel transcriptomic alterations in poorly differentiated endometrial carcinomas: evidence from South African women.Front Oncol202641952686PubTator, text miningPubMed
2H-pyrazolo[3,4-d]pyrimidin-4-amine derivatives as novel selective fibroblast growth factor receptor 2 (FGFR2) inhibitors.J Enzyme Inhib Med Chem202641910341PubTator, text miningPubMed
FGF family in health and disease.Mol Biomed202641832306PubTator, text miningPubMed
Functional insights into the biosynthesis of antifungal mandimycin.Pest Manag Sci202641821138PubTator, text miningPubMed

1 to 10 of 1,537

See all 1,537 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10818

GET https://conductscience.org/api/genes/v1/10818/patents?page=2