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Gene · 10840

ALDH1L1: aldehyde dehydrogenase 1 family member L1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ALDH1L1: aldehyde dehydrogenase 1 family member L1. Genes, record 10840. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10840

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Gene

Symbol
ALDH1L1
HGNC
Name
aldehyde dehydrogenase 1 family member L1
HGNC
NCBI Gene ID
10840
NCBI Gene
HGNC ID
HGNC:3978
HGNC
Ensembl
ENSG00000144908
NCBI Gene
Aliases
10-FTHFDH, 10-fTHF, FDH, FTHFD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75891Cytosolic 10-formyltetrahydrofolate dehydrogenase9024Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437002O75891Espacenet
JP 2026004568 A2026-01-1437005O75891Espacenet
EP 4650780 A22025-11-1911028O75891Espacenet
EP 4641201 A22025-10-2911454O75891Espacenet
JP 2025517969 A2025-06-1211454O75891Espacenet
JP 2025517970 A2025-06-1211028O75891Espacenet
JP 2025062604 A2025-04-143850O75891Espacenet
JP 2025062604 A2025-04-143858O75891Espacenet
JP 2025032204 A2025-03-1124390O75891Espacenet
JP 2025032204 A2025-03-1124392O75891Espacenet

1 to 10 of 36

See all 36 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,307

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleALDH1L1 papersNewest fiscal year
P30DK056350Nutrition Obesity Research Center (NORC)72025
P30AG062421Massachusetts Alzheimer's Disease Research Center (MADRC)52025
P30CA072720Cancer Center Support Grant52025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures52025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant42025
P51OD011132Emory National Primate Research Center42025
R01DK126666Mechanistic and metabolomic underpinnings of ALDH1L1 polymorphisms in the regulation of glycine metabolism42025
P30CA008748Cancer Center Support Grant32025
P30CA016056Roswell Park Cancer Center Support Grant32025
R01AA011147Ethanol and aldehyde dehydrogenases in health and disease32025

1 to 10 of 1,307Source NIH's project files

See all 1,307 nih grants

Papers1,409

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dynamically Coupled Network-Guided Engineering of Amine Dehydrogenase With Cofactor Recycling for Efficient Biosynthesis of (R)-3-Aminobutanol.Biotechnol Bioeng202642557781PubTator, text miningPubMed
Folic acid prevention of neural tube defects requires retinoic acid produced by ALDH1L1.Proc Natl Acad Sci U S A202642531027PubTator, text miningPubMed
The mycobacterial selenocysteine machinery: presence and expression.RNA Biol202642528383PubTator, text miningPubMed
Detecting Vibrational Energy Transfer into an Enzyme Active Site via a Transition State Analog.J Phys Chem Lett202642360871PubTator, text miningPubMed
Microbial Responses and Metabolic Mechanisms During Anaerobic Degradation of N,N-Dimethylformamide by Co-Cultured Sludge.Microorganisms202642354797PubTator, text miningPubMed
Structural basis of regioselective double halogenation of the β-carboline tryptoline by the single-component halogenase AetF.Acta Crystallogr D Struct Biol202642329691PubTator, text miningPubMed
Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma.Front Cell Dev Biol202642326014PubTator, text miningPubMed
Clinical implications of 10-formyltetrahydrofolate dehydrogenase expression in hormone receptor-positive breast cancer.Front Oncol202642266668PubTator, text miningPubMed
Electroenzymatic CO2 Reduction Through Hollow Covalent Organic Framework-Immobilized Enzyme With Neutral Red-Modified Electrode.ChemSusChem202642213054PubTator, text miningPubMed
Formate Dehydrogenase: The Role of the AMP Cofactor Fragment in Stabilization of the Transition State for Enzyme-Catalyzed Hydride Transfer.ACS Omega202642146174PubTator, text miningPubMed

1 to 10 of 1,409

See all 1,409 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10840

GET https://conductscience.org/api/genes/v1/10840/patents?page=2