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HPSE: heparanase

1 protein, 95 patents, 1 drug, 9 trials, 1,687 NIH grants and 4,675 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHPSEHGNC
NameheparanaseHGNC
NCBI Gene ID10855NCBI Gene
HGNC IDHGNC:5164HGNC
EnsemblENSG00000173083NCBI Gene
AliasesHPA, HPA1, HPR1, HPSE1, HSE1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9Y251Heparanase54358Ensembl, GeneID, HGNCUniProt

Patents 95

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4725503 A22026-04-152667Q9Y251Espacenet
JP 2026035690 A2026-03-042667Q9Y251Espacenet
JP 2026021445 A2026-02-103117Q9Y251Espacenet
JP 2026002845 A2026-01-084Q9Y251Espacenet
JP 2025172069 A2025-11-20538Q9Y251Espacenet
JP 2025172069 A2025-11-20539Q9Y251Espacenet
EP 4650780 A22025-11-194537Q9Y251Espacenet
US 12465641 B22025-11-11211Q9Y251Espacenet
JP 2025147176 A2025-10-066550Q9Y251Espacenet
JP 2025147176 A2025-10-066551Q9Y251Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
MUPARFOSTATCHEMBL4297163Heparanase inhibitorINHIBITORChEMBL

Trials 9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01402908MUPARFOSTATPHASE32020-12-30ClinicalTrials.gov
NCT00568308MUPARFOSTATPHASE3ClinicalTrials.gov
NCT00268593MUPARFOSTATPHASE2ClinicalTrials.gov
NCT00247728MUPARFOSTATPHASE22020-11-12ClinicalTrials.gov
NCT00130442MUPARFOSTATPHASE22021-01-22ClinicalTrials.gov
NCT00103389MUPARFOSTATPHASE2ClinicalTrials.gov
NCT00097851MUPARFOSTATPHASE2ClinicalTrials.gov
NCT00073892MUPARFOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT00068172MUPARFOSTATPHASE1/PHASE2ClinicalTrials.gov

NIH grants 1687

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30EY001792P30 Core Grant for Vision Research192,025NIH's project files
R01EY024710A new molecular therapy against ocular herpes182,025NIH's project files
R01EY029426HPSE in Ocular Herpes Infection182,025NIH's project files
P30CA012197Cancer Center Support Grant122,025NIH's project files
P30CA008748Cancer Center Support Grant92,025NIH's project files
P30CA013148Comprehensive Cancer Center Support Grant92,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant72,025NIH's project files
R01AR061758Pathogenic Mechanisms in Hereditary Multiple Exostoses Syndrome72,025NIH's project files
P30CA016059Massey Cancer Center - Cancer Center Support Grant62,025NIH's project files
P30CA086862Cancer Center Support Grant62,025NIH's project files

Papers 4675

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42815788PubTator, text miningPubMed
42810647PubTator, text miningPubMed
42794639PubTator, text miningPubMed
42775555PubTator, text miningPubMed
42771473PubTator, text miningPubMed
42738352PubTator, text miningPubMed
42733297PubTator, text miningPubMed
42717131PubTator, text miningPubMed
42697042PubTator, text miningPubMed
42694774PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license