Gene · 10856
RUVBL2: RuvB like AAA ATPase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RUVBL2: RuvB like AAA ATPase 2. Genes, record 10856. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10856
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9Y230 | RuvB-like 2 | 463 | 38 | Ensembl, GeneID, HGNC |
Source UniProt
Patents57
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 62506 | Q9Y230 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 62508 | Q9Y230 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 18030 | Q9Y230 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 9264 | Q9Y230 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 18030 | Q9Y230 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 35154 | Q9Y230 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 9264 | Q9Y230 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 35154 | Q9Y230 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 35154 | Q9Y230 | Espacenet |
| JP 2023513118 A | 2023-03-30 | 7 | Q9Y230 | Espacenet |
1 to 10 of 57
See all 57 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,117
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RUVBL2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 4 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 4 | 2025 |
| ZIASC010074 | HSP90 and HSP70 Chaperone Proteins and Interactors in Cellular Signal Transduction | 4 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 3 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 3 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 3 | 2025 |
| P30CA045508 | CSHL Cancer Center Support Grant | 3 | 2025 |
| P30CA142543 | UT Southwestern Medical Center Simmons Comprehensive Cancer Center | 3 | 2025 |
1 to 10 of 1,117Source NIH's project files
See all 1,117 nih grantsPapers1,341
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| SUMOylated Reptin maintains low intracellular ROS levels by activating mitophagy to drive gemcitabine resistance in gallbladder cancer. | Cell Death Dis | 2026 | 42716921 | PubTator, text mining | PubMed |
| Insights into the function and structure of the R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D1) chaperone complex. | Cell Stress Chaperones | 2026 | 42248294 | PubTator, text mining | PubMed |
| Analysis of RUVBL2 expression in malignant melanoma and its correlation with prognosis and immune infiltration. | Ital J Dermatol Venerol | 2026 | 42189027 | PubTator, text mining | PubMed |
| PIWIL1 activates the R2TP-TELO2-mTORC1 axis independently of piRNA to promote TOP mRNA translation in gastric cancer. | Oncogene | 2026 | 42020726 | PubTator, text mining | PubMed |
| Rapid Optimization Enabled by Single-Molecule Tracking: Discovery of a Potent RUVBL1/2 Inhibitor to Evaluate the Targeting of MYC-Driven Cancers. | J Med Chem | 2026 | 42017951 | PubTator, text mining | PubMed |
| RPAP3: Structural evolution, chaperone networks, and disease implications of a transcriptional Co-chaperone. | J Biol Chem | 2026 | 41966271 | PubTator, text mining | PubMed |
| RUVBL1 and RUVBL2 are druggable MYC effector regulators in neuroblastoma cells. | iScience | 2026 | 41940329 | PubTator, text mining | PubMed |
| Methylated PIH1D1 as a Circulating Biomarker for Anthracycline-Related Cardiac Remodeling: Promise and Pragmatics. | JACC Basic Transl Sci | 2026 | 41846067 | PubTator, text mining | PubMed |
| Single-Cell and Mendelian Randomization Analyses Identify Key Genes Common to COVID-19 and Multiple Sclerosis. | Viral Immunol | 2026 | 41841545 | PubTator, text mining | PubMed |
| Development and validation of a gemcitabine sensitivity-related long noncoding RNA signature for predicting the prognosis and subtypes of bladder cancer. | Transl Androl Urol | 2026 | 41809777 | PubTator, text mining | PubMed |
1 to 10 of 1,341
See all 1,341 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10856
GET https://conductscience.org/api/genes/v1/10856/patents?page=2