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Gene · 10856

RUVBL2: RuvB like AAA ATPase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RUVBL2: RuvB like AAA ATPase 2. Genes, record 10856. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10856

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Gene

Symbol
RUVBL2
HGNC
Name
RuvB like AAA ATPase 2
HGNC
NCBI Gene ID
10856
NCBI Gene
HGNC ID
HGNC:10475
HGNC
Ensembl
ENSG00000183207
NCBI Gene
Aliases
CGI-46, ECP-51, ECP51, INO80J, REPTIN, RVB2, Reptin52, Rvb2, TAP54-beta, TIH2, TIP48, TIP49B, TIP49b
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y230RuvB-like 246338Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1462506Q9Y230Espacenet
JP 2026004568 A2026-01-1462508Q9Y230Espacenet
EP 4650780 A22025-11-1918030Q9Y230Espacenet
EP 4641202 A22025-10-299264Q9Y230Espacenet
JP 2025517970 A2025-06-1218030Q9Y230Espacenet
JP 2025032204 A2025-03-1135154Q9Y230Espacenet
KR 1020250017231 A2025-02-049264Q9Y230Espacenet
EP 4461818 A22024-11-1335154Q9Y230Espacenet
JP 2023058610 A2023-04-2535154Q9Y230Espacenet
JP 2023513118 A2023-03-307Q9Y230Espacenet

1 to 10 of 57

See all 57 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,117

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRUVBL2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
P30CA008748Cancer Center Support Grant52025
P30CA036727Buffett Cancer Center Support Grant42025
P40OD010440Caenorhabditis Genetics Center42025
ZIASC010074HSP90 and HSP70 Chaperone Proteins and Interactors in Cellular Signal Transduction42025
P01CA013106Targeting Transcription and Splicing in Cancer32025
P30CA023108Cancer Center Support Grant32025
P30CA033572Cancer Center Support Grant32025
P30CA045508CSHL Cancer Center Support Grant32025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center32025

1 to 10 of 1,117Source NIH's project files

See all 1,117 nih grants

Papers1,341

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SUMOylated Reptin maintains low intracellular ROS levels by activating mitophagy to drive gemcitabine resistance in gallbladder cancer.Cell Death Dis202642716921PubTator, text miningPubMed
Insights into the function and structure of the R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D1) chaperone complex.Cell Stress Chaperones202642248294PubTator, text miningPubMed
Analysis of RUVBL2 expression in malignant melanoma and its correlation with prognosis and immune infiltration.Ital J Dermatol Venerol202642189027PubTator, text miningPubMed
PIWIL1 activates the R2TP-TELO2-mTORC1 axis independently of piRNA to promote TOP mRNA translation in gastric cancer.Oncogene202642020726PubTator, text miningPubMed
Rapid Optimization Enabled by Single-Molecule Tracking: Discovery of a Potent RUVBL1/2 Inhibitor to Evaluate the Targeting of MYC-Driven Cancers.J Med Chem202642017951PubTator, text miningPubMed
RPAP3: Structural evolution, chaperone networks, and disease implications of a transcriptional Co-chaperone.J Biol Chem202641966271PubTator, text miningPubMed
RUVBL1 and RUVBL2 are druggable MYC effector regulators in neuroblastoma cells.iScience202641940329PubTator, text miningPubMed
Methylated PIH1D1 as a Circulating Biomarker for Anthracycline-Related Cardiac Remodeling: Promise and Pragmatics.JACC Basic Transl Sci202641846067PubTator, text miningPubMed
Single-Cell and Mendelian Randomization Analyses Identify Key Genes Common to COVID-19 and Multiple Sclerosis.Viral Immunol202641841545PubTator, text miningPubMed
Development and validation of a gemcitabine sensitivity-related long noncoding RNA signature for predicting the prognosis and subtypes of bladder cancer.Transl Androl Urol202641809777PubTator, text miningPubMed

1 to 10 of 1,341

See all 1,341 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10856

GET https://conductscience.org/api/genes/v1/10856/patents?page=2