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Gene · 10857

PGRMC1: progesterone receptor membrane component 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PGRMC1: progesterone receptor membrane component 1. Genes, record 10857. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10857

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Gene

Symbol
PGRMC1
HGNC
Name
progesterone receptor membrane component 1
HGNC
NCBI Gene ID
10857
NCBI Gene
HGNC ID
HGNC:16090
HGNC
Ensembl
ENSG00000101856
NCBI Gene
Aliases
Dap1, HPR6.6, IZA, MPR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00264Membrane-associated progesterone receptor component 11951Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459112O00264Espacenet
EP 4650780 A22025-11-19409O00264Espacenet
EP 4640849 A22025-10-2948O00264Espacenet
EP 4641201 A22025-10-29281O00264Espacenet
JP 2025529142 A2025-09-043456O00264Espacenet
US 12371689 B22025-07-293456O00264Espacenet
JP 2025519096 A2025-06-2448O00264Espacenet
JP 2025517969 A2025-06-12281O00264Espacenet
JP 2025517970 A2025-06-12409O00264Espacenet
WO 2025093687 A12025-05-0839O00264Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,040

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePGRMC1 papersNewest fiscal year
ZIAHD001607Protein Trafficking In The Endosomal-Lysosomal System82025
P30CA008748Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant52025
P51OD011092Support for National Primate Research Center42025
P01AG026572Perimenopause in Brain Aging and Alzheimer's Disease32025
P30CA016058Cancer Center Support Grant32025
P30CA091842Cancer Center Support Grant32025
T32CA009621Surgical Oncology Basic Science and Translational Research Training Program32025
ZIADA000206Biological And Biochemical Characterization Of Sigma Receptors32025
K12HD085809OHSU Women's Reproductive Health Research K12 Program22025

1 to 10 of 1,040Source NIH's project files

See all 1,040 nih grants

Papers1,901

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cyclical Iron Homeostasis: The Role of Sex Hormones in Female Iron Regulation.Front Biosci (Landmark Ed)202642811967PubTator, text miningPubMed
Epitranscriptomic stabilization of PGRMC1 by the METTL3-IGF2BP1 axis promotes ovarian cancer progression.Cell Signal202642777928PubTator, text miningPubMed
COMMD3 coordinates mannose-6-phosphate receptor trafficking to sustain lysosomal protease maturation.Res Sq202642774043PubTator, text miningPubMed
Absence of Receptor Mediated Functional Progesterone Withdrawal in the Decidua During Labor-like Inflammatory Conditions.Am J Reprod Immunol202642748907PubTator, text miningPubMed
Identification of TIMP1 as a Key Regulator of Ferroptosis in Ulcerative Colitis Through Bioinformatics and Functional Experiments.Gastroenterol Res Pract202642592064PubTator, text miningPubMed
Arsenic Exposure During Pregnancy: Impacts to Maternal and Offspring Cardiovascular Health.Med Res Arch202642459294PubTator, text miningPubMed
PGRMC1 suppression enhances progesterone responsiveness in stromal cells of ovarian endometrioma.Reproduction202642406423PubTator, text miningPubMed
SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism.Cell Rep202642287635PubTator, text miningPubMed
A proteogenomic RNA processing mechanism drives sex differences in meningioma.Res Sq202642282014PubTator, text miningPubMed
Uncovering Common Anti-Inflammatory Targets of DHEA, 5-AED, Progesterone, and Gestobutanoyl.Curr Med Chem202642163697PubTator, text miningPubMed

1 to 10 of 1,901

See all 1,901 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10857

GET https://conductscience.org/api/genes/v1/10857/patents?page=2