Gene · 10857
PGRMC1: progesterone receptor membrane component 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PGRMC1: progesterone receptor membrane component 1. Genes, record 10857. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10857
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O00264 | Membrane-associated progesterone receptor component 1 | 195 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents43
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 59112 | O00264 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 409 | O00264 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 48 | O00264 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 281 | O00264 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3456 | O00264 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3456 | O00264 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 48 | O00264 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 281 | O00264 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 409 | O00264 | Espacenet |
| WO 2025093687 A1 | 2025-05-08 | 39 | O00264 | Espacenet |
1 to 10 of 43
See all 43 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,040
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PGRMC1 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHD001607 | Protein Trafficking In The Endosomal-Lysosomal System | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P51OD011092 | Support for National Primate Research Center | 4 | 2025 |
| P01AG026572 | Perimenopause in Brain Aging and Alzheimer's Disease | 3 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 3 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 3 | 2025 |
| T32CA009621 | Surgical Oncology Basic Science and Translational Research Training Program | 3 | 2025 |
| ZIADA000206 | Biological And Biochemical Characterization Of Sigma Receptors | 3 | 2025 |
| K12HD085809 | OHSU Women's Reproductive Health Research K12 Program | 2 | 2025 |
1 to 10 of 1,040Source NIH's project files
See all 1,040 nih grantsPapers1,901
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Cyclical Iron Homeostasis: The Role of Sex Hormones in Female Iron Regulation. | Front Biosci (Landmark Ed) | 2026 | 42811967 | PubTator, text mining | PubMed |
| Epitranscriptomic stabilization of PGRMC1 by the METTL3-IGF2BP1 axis promotes ovarian cancer progression. | Cell Signal | 2026 | 42777928 | PubTator, text mining | PubMed |
| COMMD3 coordinates mannose-6-phosphate receptor trafficking to sustain lysosomal protease maturation. | Res Sq | 2026 | 42774043 | PubTator, text mining | PubMed |
| Absence of Receptor Mediated Functional Progesterone Withdrawal in the Decidua During Labor-like Inflammatory Conditions. | Am J Reprod Immunol | 2026 | 42748907 | PubTator, text mining | PubMed |
| Identification of TIMP1 as a Key Regulator of Ferroptosis in Ulcerative Colitis Through Bioinformatics and Functional Experiments. | Gastroenterol Res Pract | 2026 | 42592064 | PubTator, text mining | PubMed |
| Arsenic Exposure During Pregnancy: Impacts to Maternal and Offspring Cardiovascular Health. | Med Res Arch | 2026 | 42459294 | PubTator, text mining | PubMed |
| PGRMC1 suppression enhances progesterone responsiveness in stromal cells of ovarian endometrioma. | Reproduction | 2026 | 42406423 | PubTator, text mining | PubMed |
| SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism. | Cell Rep | 2026 | 42287635 | PubTator, text mining | PubMed |
| A proteogenomic RNA processing mechanism drives sex differences in meningioma. | Res Sq | 2026 | 42282014 | PubTator, text mining | PubMed |
| Uncovering Common Anti-Inflammatory Targets of DHEA, 5-AED, Progesterone, and Gestobutanoyl. | Curr Med Chem | 2026 | 42163697 | PubTator, text mining | PubMed |
1 to 10 of 1,901
See all 1,901 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10857
GET https://conductscience.org/api/genes/v1/10857/patents?page=2