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Gene · 10858

CYP46A1: cytochrome P450 family 46 subfamily A member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CYP46A1: cytochrome P450 family 46 subfamily A member 1. Genes, record 10858. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10858

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Gene

Symbol
CYP46A1
HGNC
Name
cytochrome P450 family 46 subfamily A member 1
HGNC
NCBI Gene ID
10858
NCBI Gene
HGNC ID
HGNC:2641
HGNC
Ensembl
ENSG00000036530
NCBI Gene
Aliases
CP46, CYP46
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y6A2Cholesterol 24-hydroxylase50021Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026094425 A2026-06-097Q9Y6A2Espacenet
JP 2026004568 A2026-01-1442941Q9Y6A2Espacenet
JP 2025166191 A2025-11-0527Q9Y6A2Espacenet
JP 2025147176 A2025-10-063908Q9Y6A2Espacenet
JP 2025529142 A2025-09-046105Q9Y6A2Espacenet
US 12371689 B22025-07-296105Q9Y6A2Espacenet
KR 1020250096876 A2025-06-277Q9Y6A2Espacenet
JP 2025028160 A2025-02-283908Q9Y6A2Espacenet
JP 2025503910 A2025-02-062Q9Y6A2Espacenet
JP 2025503910 A2025-02-06109Q9Y6A2Espacenet

1 to 10 of 46

See all 46 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
SOTICLESTATCHEMBL4298172Cholesterol 24-hydroxylase inhibitorINHIBITOR

Source ChEMBL

Trials8

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06422377SOTICLESTATPHASE32025-03-06ClinicalTrials.gov
NCT05163314SOTICLESTATPHASE3ClinicalTrials.gov
NCT04940624SOTICLESTATPHASE32025-01-01ClinicalTrials.gov
NCT04938427SOTICLESTATPHASE32024-08-21ClinicalTrials.gov
NCT03990649SOTICLESTATPHASE22021-07-15ClinicalTrials.gov
NCT03650452SOTICLESTATPHASE22021-02-18ClinicalTrials.gov
NCT03635073SOTICLESTATPHASE22026-03-19ClinicalTrials.gov
NCT03166215SOTICLESTATPHASE1/PHASE22020-01-10ClinicalTrials.gov

NIH grants479

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCYP46A1 papersNewest fiscal year
P30EY011373CWRU NEI Vision Center Core Grant252025
T32EY007157CWRU-Visual Sciences Training Program52025
R35GM118145Nanoscale Approaches to Understanding Membrane Protein Function42025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
P01AG026572Perimenopause in Brain Aging and Alzheimer's Disease22025
P30AG062421Massachusetts Alzheimer's Disease Research Center (MADRC)22025
P30DK020579Diabetes Research Center22025
P30DK056341Washington University Nutrition Obesity Research Center22025
R01EY016077Dyslipidemia and Diabetic Retinopathy22025
U01NS114312Multi-Site Validation of Biomarkers and Core Clinical Outcome Measures for Clinical Trials Readiness in CDKL5 Deficiency Disorder22025

1 to 10 of 479Source NIH's project files

See all 479 nih grants

Papers879

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Antiseizure Medications in Development: Novel Mechanisms, Precision Therapy, and the Move Towards Disease Modification.Curr Issues Mol Biol202642651828PubTator, text miningPubMed
From astrocyte cholesterol synthesis to synaptic dysfunction: mechanisms of neuron-glia lipid coupling.Mol Biol Rep202642525165PubTator, text miningPubMed
Disruption of dopamine transmission by cholesterol depletion is associated with alterations in protein lipid raft partitioning and actin dynamics.Neuropharmacology202642288194PubTator, text miningPubMed
ARCH × Φ: Sterols and the evolution of gated biological execution.Biosystems202642107486PubTator, text miningPubMed
Soticlestat for drug-resistant epilepsy: Current evidence and clinical perspectives.Seizure202641980323PubTator, text miningPubMed
Decoding the Metabolic Signatures of Neurodegeneration Diseases: Advances in Mass Spectrometry-Based Metabolomics.Metabolites202641893355PubTator, text miningPubMed
Physiological Functions of Side-Chain-Retaining Sterols in the Brain and Their Roles in Neurodegenerative Diseases.Metabolites202641893338PubTator, text miningPubMed
A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox-Gastaut syndrome.Epilepsia202641891667PubTator, text miningPubMed
Gypenosides mitigate acrylamide-induced oxidative stress, inflammation and lipid metabolic dysregulation in retinal pigment epithelial cells and in zebrafish embryos.Mol Biol Rep202641848940PubTator, text miningPubMed
Immune Modulatory Oxysterols Produced from Cholesterol-Containing Lipid Nanoparticles Regulate Tumor Growth.ACS Nano202641825961PubTator, text miningPubMed

1 to 10 of 879

See all 879 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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