Gene · 10858
CYP46A1: cytochrome P450 family 46 subfamily A member 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CYP46A1: cytochrome P450 family 46 subfamily A member 1. Genes, record 10858. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10858
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9Y6A2 | Cholesterol 24-hydroxylase | 500 | 21 | Ensembl, GeneID, HGNC |
Source UniProt
Patents46
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026094425 A | 2026-06-09 | 7 | Q9Y6A2 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 42941 | Q9Y6A2 | Espacenet |
| JP 2025166191 A | 2025-11-05 | 27 | Q9Y6A2 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 3908 | Q9Y6A2 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6105 | Q9Y6A2 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6105 | Q9Y6A2 | Espacenet |
| KR 1020250096876 A | 2025-06-27 | 7 | Q9Y6A2 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 3908 | Q9Y6A2 | Espacenet |
| JP 2025503910 A | 2025-02-06 | 2 | Q9Y6A2 | Espacenet |
| JP 2025503910 A | 2025-02-06 | 109 | Q9Y6A2 | Espacenet |
1 to 10 of 46
See all 46 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| SOTICLESTAT | CHEMBL4298172 | Cholesterol 24-hydroxylase inhibitor | INHIBITOR |
Source ChEMBL
Trials8
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06422377 | SOTICLESTAT | PHASE3 | 2025-03-06 | ClinicalTrials.gov |
| NCT05163314 | SOTICLESTAT | PHASE3 | ClinicalTrials.gov | |
| NCT04940624 | SOTICLESTAT | PHASE3 | 2025-01-01 | ClinicalTrials.gov |
| NCT04938427 | SOTICLESTAT | PHASE3 | 2024-08-21 | ClinicalTrials.gov |
| NCT03990649 | SOTICLESTAT | PHASE2 | 2021-07-15 | ClinicalTrials.gov |
| NCT03650452 | SOTICLESTAT | PHASE2 | 2021-02-18 | ClinicalTrials.gov |
| NCT03635073 | SOTICLESTAT | PHASE2 | 2026-03-19 | ClinicalTrials.gov |
| NCT03166215 | SOTICLESTAT | PHASE1/PHASE2 | 2020-01-10 | ClinicalTrials.gov |
NIH grants479
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CYP46A1 papers | Newest fiscal year |
|---|---|---|---|
| P30EY011373 | CWRU NEI Vision Center Core Grant | 25 | 2025 |
| T32EY007157 | CWRU-Visual Sciences Training Program | 5 | 2025 |
| R35GM118145 | Nanoscale Approaches to Understanding Membrane Protein Function | 4 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
| P01AG026572 | Perimenopause in Brain Aging and Alzheimer's Disease | 2 | 2025 |
| P30AG062421 | Massachusetts Alzheimer's Disease Research Center (MADRC) | 2 | 2025 |
| P30DK020579 | Diabetes Research Center | 2 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 2 | 2025 |
| R01EY016077 | Dyslipidemia and Diabetic Retinopathy | 2 | 2025 |
| U01NS114312 | Multi-Site Validation of Biomarkers and Core Clinical Outcome Measures for Clinical Trials Readiness in CDKL5 Deficiency Disorder | 2 | 2025 |
1 to 10 of 479Source NIH's project files
See all 479 nih grantsPapers879
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Antiseizure Medications in Development: Novel Mechanisms, Precision Therapy, and the Move Towards Disease Modification. | Curr Issues Mol Biol | 2026 | 42651828 | PubTator, text mining | PubMed |
| From astrocyte cholesterol synthesis to synaptic dysfunction: mechanisms of neuron-glia lipid coupling. | Mol Biol Rep | 2026 | 42525165 | PubTator, text mining | PubMed |
| Disruption of dopamine transmission by cholesterol depletion is associated with alterations in protein lipid raft partitioning and actin dynamics. | Neuropharmacology | 2026 | 42288194 | PubTator, text mining | PubMed |
| ARCH × Φ: Sterols and the evolution of gated biological execution. | Biosystems | 2026 | 42107486 | PubTator, text mining | PubMed |
| Soticlestat for drug-resistant epilepsy: Current evidence and clinical perspectives. | Seizure | 2026 | 41980323 | PubTator, text mining | PubMed |
| Decoding the Metabolic Signatures of Neurodegeneration Diseases: Advances in Mass Spectrometry-Based Metabolomics. | Metabolites | 2026 | 41893355 | PubTator, text mining | PubMed |
| Physiological Functions of Side-Chain-Retaining Sterols in the Brain and Their Roles in Neurodegenerative Diseases. | Metabolites | 2026 | 41893338 | PubTator, text mining | PubMed |
| A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox-Gastaut syndrome. | Epilepsia | 2026 | 41891667 | PubTator, text mining | PubMed |
| Gypenosides mitigate acrylamide-induced oxidative stress, inflammation and lipid metabolic dysregulation in retinal pigment epithelial cells and in zebrafish embryos. | Mol Biol Rep | 2026 | 41848940 | PubTator, text mining | PubMed |
| Immune Modulatory Oxysterols Produced from Cholesterol-Containing Lipid Nanoparticles Regulate Tumor Growth. | ACS Nano | 2026 | 41825961 | PubTator, text mining | PubMed |
1 to 10 of 879
See all 879 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10858
GET https://conductscience.org/api/genes/v1/10858/patents?page=2