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Gene · 10920

COPS8: COP9 signalosome subunit 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COPS8: COP9 signalosome subunit 8. Genes, record 10920. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10920

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Gene

Symbol
COPS8
HGNC
Name
COP9 signalosome subunit 8
HGNC
NCBI Gene ID
10920
NCBI Gene
HGNC ID
HGNC:24335
HGNC
Ensembl
ENSG00000198612
NCBI Gene
Aliases
COP9, CSN8, MGC1297, SGN8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99627COP9 signalosome complex subunit 820928Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-197058Q99627Espacenet
JP 2025517970 A2025-06-127058Q99627Espacenet
US 11564998 B22023-01-315847Q99627Espacenet
US 11459613 B22022-10-0418Q99627Espacenet
US 11446398 B22022-09-2019759Q99627Espacenet
JP 2022524081 A2022-04-27122730Q99627Espacenet
US 11078247 B22021-08-032462Q99627Espacenet
US 10463751 B22019-11-055847Q99627Espacenet
EP 3347717 A12018-07-1818Q99627Espacenet
JP 2018023373 A2018-02-1528574Q99627Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants978

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOPS8 papersNewest fiscal year
P30CA016672Cancer Center Support Grant252025
P30CA021765Cancer Center Support Grant (CCSG)102025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control82025
P30CA008748Cancer Center Support Grant52025
P30AI027763UCSF-Bay Area Center for AIDS Research42025
R01DK095491Indole dysbiosis and mucosal inflammation42025
R35ES031638Watching cooperative interactions between base and nucleotide excision repair proteins42025
P01CA155258Integrative Oncogenomics of Multiple Myeloma32025
P30CA054174Mays Cancer Center at UT Health SA32025
R01CA214608The molecular basis of IMiD induced neo-substrate recruitment to the CRL4CRBN ubiquitin E3 ligase32025

1 to 10 of 978Source NIH's project files

See all 978 nih grants

Papers1,532

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The COP9 signalosome subunit CSN1 regulates glioblastoma stem cell growth.PLoS One202642752691PubTator, text miningPubMed
COPS7B Drives Malignant Progression of Glioblastoma Through Translational Upregulation of the Downstream Functional Effector CLU.Int J Mol Sci202642589629PubTator, text miningPubMed
The Allosteric Revolution: From Static Structures to Conformational Ensembles and Next-Generation Therapeutics.J Mol Biol202642580397PubTator, text miningPubMed
COP9 signalosome 8 mediated autophagy drives proliferation, invasion, and metastasis in pancreatic ductal adenocarcinoma.Biochem Biophys Res Commun202642401010PubTator, text miningPubMed
Machine learning integration of bulk and single-cell RNA-Seq data reveals COPS2 as a central immune regulator in deep vein thrombosis.Am J Transl Res202642325795PubTator, text miningPubMed
In silico structural and disorder prediction of the tomato yellow leaf curl virus C2 protein and experimental assessment of subcellular localization and HR-like response.J Comput Aided Mol Des202642295476PubTator, text miningPubMed
Transcriptome Analysis Identifies Proteostasis and Cell Survival Pathway Disruption in Peripartum Cardiomyopathy, Leading to Heart Failure.Cells202642041565PubTator, text miningPubMed
Upregulation of CSN8 induces a unique senescence-like state with robust tumor-promoting properties in epithelial ovarian cancer cells under hypoxia.J Transl Med202642001097PubTator, text miningPubMed
Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia.Cardiovasc Res202641861053PubTator, text miningPubMed
ZOMES: expanding roles of the PCI complexes from protein metabolism to drug discovery.NPJ Metab Health Dis202641760881PubTator, text miningPubMed

1 to 10 of 1,532

See all 1,532 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10920

GET https://conductscience.org/api/genes/v1/10920/patents?page=2