Gene · 10920
COPS8: COP9 signalosome subunit 8
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. COPS8: COP9 signalosome subunit 8. Genes, record 10920. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10920
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99627 | COP9 signalosome complex subunit 8 | 209 | 28 | Ensembl, GeneID, HGNC |
Source UniProt
Patents21
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 7058 | Q99627 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7058 | Q99627 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5847 | Q99627 | Espacenet |
| US 11459613 B2 | 2022-10-04 | 18 | Q99627 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 19759 | Q99627 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 122730 | Q99627 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 2462 | Q99627 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 5847 | Q99627 | Espacenet |
| EP 3347717 A1 | 2018-07-18 | 18 | Q99627 | Espacenet |
| JP 2018023373 A | 2018-02-15 | 28574 | Q99627 | Espacenet |
1 to 10 of 21
See all 21 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants978
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | COPS8 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 25 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 10 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 4 | 2025 |
| R01DK095491 | Indole dysbiosis and mucosal inflammation | 4 | 2025 |
| R35ES031638 | Watching cooperative interactions between base and nucleotide excision repair proteins | 4 | 2025 |
| P01CA155258 | Integrative Oncogenomics of Multiple Myeloma | 3 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 3 | 2025 |
| R01CA214608 | The molecular basis of IMiD induced neo-substrate recruitment to the CRL4CRBN ubiquitin E3 ligase | 3 | 2025 |
1 to 10 of 978Source NIH's project files
See all 978 nih grantsPapers1,532
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The COP9 signalosome subunit CSN1 regulates glioblastoma stem cell growth. | PLoS One | 2026 | 42752691 | PubTator, text mining | PubMed |
| COPS7B Drives Malignant Progression of Glioblastoma Through Translational Upregulation of the Downstream Functional Effector CLU. | Int J Mol Sci | 2026 | 42589629 | PubTator, text mining | PubMed |
| The Allosteric Revolution: From Static Structures to Conformational Ensembles and Next-Generation Therapeutics. | J Mol Biol | 2026 | 42580397 | PubTator, text mining | PubMed |
| COP9 signalosome 8 mediated autophagy drives proliferation, invasion, and metastasis in pancreatic ductal adenocarcinoma. | Biochem Biophys Res Commun | 2026 | 42401010 | PubTator, text mining | PubMed |
| Machine learning integration of bulk and single-cell RNA-Seq data reveals COPS2 as a central immune regulator in deep vein thrombosis. | Am J Transl Res | 2026 | 42325795 | PubTator, text mining | PubMed |
| In silico structural and disorder prediction of the tomato yellow leaf curl virus C2 protein and experimental assessment of subcellular localization and HR-like response. | J Comput Aided Mol Des | 2026 | 42295476 | PubTator, text mining | PubMed |
| Transcriptome Analysis Identifies Proteostasis and Cell Survival Pathway Disruption in Peripartum Cardiomyopathy, Leading to Heart Failure. | Cells | 2026 | 42041565 | PubTator, text mining | PubMed |
| Upregulation of CSN8 induces a unique senescence-like state with robust tumor-promoting properties in epithelial ovarian cancer cells under hypoxia. | J Transl Med | 2026 | 42001097 | PubTator, text mining | PubMed |
| Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia. | Cardiovasc Res | 2026 | 41861053 | PubTator, text mining | PubMed |
| ZOMES: expanding roles of the PCI complexes from protein metabolism to drug discovery. | NPJ Metab Health Dis | 2026 | 41760881 | PubTator, text mining | PubMed |
1 to 10 of 1,532
See all 1,532 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10920
GET https://conductscience.org/api/genes/v1/10920/patents?page=2