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Gene · 10970

CKAP4: cytoskeleton associated protein 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CKAP4: cytoskeleton associated protein 4. Genes, record 10970. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10970

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Gene

Symbol
CKAP4
HGNC
Name
cytoskeleton associated protein 4
HGNC
NCBI Gene ID
10970
NCBI Gene
HGNC ID
HGNC:16991
HGNC
Ensembl
ENSG00000136026
NCBI Gene
Aliases
CLIMP-63, CLIMP63, ERGIC-63, P63, p63
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q07065Cytoskeleton-associated protein 46020Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199996Q07065Espacenet
EP 4641202 A22025-10-29565Q07065Espacenet
JP 2025529142 A2025-09-04957Q07065Espacenet
US 12371689 B22025-07-29957Q07065Espacenet
JP 2025517970 A2025-06-129996Q07065Espacenet
WO 2025088835 A2025-05-0125Q07065Espacenet
KR 1020250017231 A2025-02-04565Q07065Espacenet
WO 2024218708 A22024-10-2443Q07065Espacenet
US 11860162 B22024-01-021184Q07065Espacenet
US 11807679 B22023-11-071Q07065Espacenet

1 to 10 of 57

See all 57 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,024

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCKAP4 papersNewest fiscal year
P30CA068485Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant42025
P30CA022453CANCER CENTER SUPPORT GRANT42025
P30CA008748Cancer Center Support Grant32025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control32025
ZICBC011430CPTR - Mass Spectrometry Unit32025
P01CA022443Molecular Biology and Genetics of Human Tumor Viruses22025
P30CA045508CSHL Cancer Center Support Grant22025
P30CA046934University of Colorado Cancer Center Support Grant22025
P30CA076292Moffitt Cancer Center Support Grant22025

1 to 10 of 1,024Source NIH's project files

See all 1,024 nih grants

Papers2,190

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A longevity-associated ubiquitin E3 ligase UBE3C governs lamin B1 homeostasis through selective autophagy and delay senescence.bioRxiv202642620354PubTator, text miningPubMed
Exosome-Related Pathogenic Genes in Adenomyosis: A Multi-Omics Mendelian Randomization Study.OMICS202642610667PubTator, text miningPubMed
Senecavirus a 3C protease cleaves RETREG1 to antagonize ER-phagy and promote viral replication via endoplasmic reticulum calcium signaling.Autophagy202642576627PubTator, text miningPubMed
From Bone Marrow Reserve to Metastatic Niche: How Neutrophil-Lineage Cells Shape Skeletal Colonization.Int J Mol Sci202642450242PubTator, text miningPubMed
Plasma proteomics based on machine learning predict the early risk of kidney outcomes in patients with DKD: a prospective cohort study from UK Biobank.Front Nephrol202642445298PubTator, text miningPubMed
Development of high-affinity polyclonal antibodies against chicken CKAP4 and its application in infectious bursal disease.Int J Biol Macromol202642379451PubTator, text miningPubMed
Mendelian Randomization and Single-Cell RNA Sequencing Reveal CKAP4 and PFDN5 as Tumor Cell-Specific Causal Genes for Glioblastoma.Int J Gen Med202642369563PubTator, text miningPubMed
DKK1 activated the NF-κB pathway by binding with CKAP4 to induce PASMC oxidative stress and promote pulmonary arterial hypertension.Genes Genomics202642329343PubTator, text miningPubMed
Lipid droplet-associated gene signatures classify metabolic subtypes and identify PLIN3 as a key driver in hepatocellular carcinoma.Genes Dis202642327977PubTator, text miningPubMed
Comprehensive analysis of monocyte palmitoylation-related genes IFITM3 and CCL3-CCR5 axis in crohn's disease progression: Insights from mendelian randomization, multi-omics integration, machine learning, and SHAP methodology.
Comput Biol Chem202642269260PubTator, text miningPubMed

1 to 10 of 2,190

See all 2,190 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10970

GET https://conductscience.org/api/genes/v1/10970/patents?page=2