Gene · 10987
COPS5: COP9 signalosome subunit 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. COPS5: COP9 signalosome subunit 5. Genes, record 10987. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10987
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q92905 | COP9 signalosome complex subunit 5 | 334 | 31 | Ensembl, GeneID, HGNC |
Source UniProt
Patents32
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2025147583 A1 | 2025-07-10 | 48 | Q92905 | Espacenet |
| JP 2023551068 A | 2023-12-06 | 111 | Q92905 | Espacenet |
| JP 2023549761 A | 2023-11-29 | 111 | Q92905 | Espacenet |
| JP 2023549167 A | 2023-11-22 | 111 | Q92905 | Espacenet |
| JP 2023548973 A | 2023-11-21 | 111 | Q92905 | Espacenet |
| US 11708396 B2 | 2023-07-25 | 2430 | Q92905 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5943 | Q92905 | Espacenet |
| US 11459613 B2 | 2022-10-04 | 10 | Q92905 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 19710 | Q92905 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 122681 | Q92905 | Espacenet |
1 to 10 of 32
See all 32 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,120
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | COPS5 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 34 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 6 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
| P01CA155258 | Integrative Oncogenomics of Multiple Myeloma | 4 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 3 | 2025 |
| R01DK051496 | WNK Kinase Regulation of Thiazide-sensitive NaCl Transport | 3 | 2025 |
| R01DK098141 | Regulation of renal ion transport by the CUL3-WNK-SPAK pathway | 3 | 2025 |
| T32CA119925 | Integrated Biological Systems Training in Oncology | 3 | 2025 |
1 to 10 of 1,120Source NIH's project files
See all 1,120 nih grantsPapers2,142
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| PSMD14 as a translational target in cancer and beyond: from deubiquitination mechanisms to drug resistance and precision therapy. | Cancer Drug Resist | 2026 | 42729688 | PubTator, text mining | PubMed |
| Integrative Transcriptomics Identifies Ubiquitination-Related Genes BIRC2, COPS5, and TBK1 as Novel Biomarkers of T-Cell Dysregulation in Amyotrophic Lateral Sclerosis. | J Inflamm Res | 2026 | 42117108 | PubTator, text mining | PubMed |
| Transcriptome Analysis Identifies Proteostasis and Cell Survival Pathway Disruption in Peripartum Cardiomyopathy, Leading to Heart Failure. | Cells | 2026 | 42041565 | PubTator, text mining | PubMed |
| Alterations in NK cell subsets and the regulatory role of JAB1 in nasopharyngeal carcinoma with implications for tumor immunity and biomarker development. | Br J Cancer | 2026 | 41992060 | PubTator, text mining | PubMed |
| Machine Learning Identifies TRAPPC13/COPS5 as Biomarkers and Vesicle Transport Subtypes in Parkinson's Disease. | Can J Neurol Sci | 2026 | 41972297 | PubTator, text mining | PubMed |
| Influence of USP15 and its derived-peptide on non-small cell lung cancer immune evasion via regulating PD-L1 stability. | J Immunother Cancer | 2026 | 41922082 | PubTator, text mining | PubMed |
| Dual Roles of Ubiquitin-Specific Peptidase 10 (USP10) in Cancer. | Cells | 2026 | 41892309 | PubTator, text mining | PubMed |
| USP10 deubiquitinase: Physiological function, diseases and therapeutic target (Review). | Int J Mol Med | 2026 | 41891958 | PubTator, text mining | PubMed |
| Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia. | Cardiovasc Res | 2026 | 41861053 | PubTator, text mining | PubMed |
| Disrupting USP14-mediated PARP1 dynamics reinstates MIC-A/B-driven antigen-independent CD8+ T cell killing in glioma. | Sci Adv | 2026 | 41824572 | PubTator, text mining | PubMed |
1 to 10 of 2,142
See all 2,142 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/10987
GET https://conductscience.org/api/genes/v1/10987/patents?page=2