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Gene · 10987

COPS5: COP9 signalosome subunit 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COPS5: COP9 signalosome subunit 5. Genes, record 10987. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/10987

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Gene

Symbol
COPS5
HGNC
Name
COP9 signalosome subunit 5
HGNC
NCBI Gene ID
10987
NCBI Gene
HGNC ID
HGNC:2240
HGNC
Ensembl
ENSG00000121022
NCBI Gene
Aliases
CSN5, JAB1, MOV-34, SGN5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92905COP9 signalosome complex subunit 533431Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025147583 A12025-07-1048Q92905Espacenet
JP 2023551068 A2023-12-06111Q92905Espacenet
JP 2023549761 A2023-11-29111Q92905Espacenet
JP 2023549167 A2023-11-22111Q92905Espacenet
JP 2023548973 A2023-11-21111Q92905Espacenet
US 11708396 B22023-07-252430Q92905Espacenet
US 11564998 B22023-01-315943Q92905Espacenet
US 11459613 B22022-10-0410Q92905Espacenet
US 11446398 B22022-09-2019710Q92905Espacenet
JP 2022524081 A2022-04-27122681Q92905Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,120

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOPS5 papersNewest fiscal year
P30CA016672Cancer Center Support Grant342025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control62025
P30CA021765Cancer Center Support Grant (CCSG)52025
P01CA155258Integrative Oncogenomics of Multiple Myeloma42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant32025
R01DK051496WNK Kinase Regulation of Thiazide-sensitive NaCl Transport32025
R01DK098141Regulation of renal ion transport by the CUL3-WNK-SPAK pathway32025
T32CA119925Integrated Biological Systems Training in Oncology32025

1 to 10 of 1,120Source NIH's project files

See all 1,120 nih grants

Papers2,142

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PSMD14 as a translational target in cancer and beyond: from deubiquitination mechanisms to drug resistance and precision therapy.Cancer Drug Resist202642729688PubTator, text miningPubMed
Integrative Transcriptomics Identifies Ubiquitination-Related Genes BIRC2, COPS5, and TBK1 as Novel Biomarkers of T-Cell Dysregulation in Amyotrophic Lateral Sclerosis.J Inflamm Res202642117108PubTator, text miningPubMed
Transcriptome Analysis Identifies Proteostasis and Cell Survival Pathway Disruption in Peripartum Cardiomyopathy, Leading to Heart Failure.Cells202642041565PubTator, text miningPubMed
Alterations in NK cell subsets and the regulatory role of JAB1 in nasopharyngeal carcinoma with implications for tumor immunity and biomarker development.Br J Cancer202641992060PubTator, text miningPubMed
Machine Learning Identifies TRAPPC13/COPS5 as Biomarkers and Vesicle Transport Subtypes in Parkinson's Disease.Can J Neurol Sci202641972297PubTator, text miningPubMed
Influence of USP15 and its derived-peptide on non-small cell lung cancer immune evasion via regulating PD-L1 stability.J Immunother Cancer202641922082PubTator, text miningPubMed
Dual Roles of Ubiquitin-Specific Peptidase 10 (USP10) in Cancer.Cells202641892309PubTator, text miningPubMed
USP10 deubiquitinase: Physiological function, diseases and therapeutic target (Review).Int J Mol Med202641891958PubTator, text miningPubMed
Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia.Cardiovasc Res202641861053PubTator, text miningPubMed
Disrupting USP14-mediated PARP1 dynamics reinstates MIC-A/B-driven antigen-independent CD8+ T cell killing in glioma.Sci Adv202641824572PubTator, text miningPubMed

1 to 10 of 2,142

See all 2,142 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/10987

GET https://conductscience.org/api/genes/v1/10987/patents?page=2