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Gene · 11052

CPSF6: cleavage and polyadenylation specific factor 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CPSF6: cleavage and polyadenylation specific factor 6. Genes, record 11052. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11052

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Gene

Symbol
CPSF6
HGNC
Name
cleavage and polyadenylation specific factor 6
HGNC
NCBI Gene ID
11052
NCBI Gene
HGNC ID
HGNC:13871
HGNC
Ensembl
ENSG00000111605
NCBI Gene
Aliases
CFIM, CFIM68, CFIM72, HPBRII-4, HPBRII-7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16630Cleavage and polyadenylation specificity factor subunit 655116Ensembl, GeneID, HGNC

Source UniProt

Patents17

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441671Q16630Espacenet
EP 4650780 A22025-11-1912472Q16630Espacenet
EP 4641201 A22025-10-2913683Q16630Espacenet
JP 2025517969 A2025-06-1213683Q16630Espacenet
JP 2025517970 A2025-06-1212472Q16630Espacenet
WO 2024240908 A12024-11-2840Q16630Espacenet
US 11446398 B22022-09-2017677Q16630Espacenet
JP 2022524081 A2022-04-27120648Q16630Espacenet
JP 2019054813 A2019-04-11222106Q16630Espacenet
JP 2018153184 A2018-10-04136Q16630Espacenet

1 to 10 of 17

See all 17 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants972

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCPSF6 papersNewest fiscal year
R01AI052014HIV-1 Preintegration Trafficking and Nuclear Localization412025
R01AI120860Development of HIV capsid-targeting antivirals that affect immune response by modulating capsid stability and have improved resistance profiles142025
U54AI170791Pittsburgh Center for HIV Protein Interactions (PCHPI)142025
R01AI129862Imaging early steps of HIV-1 infection and virus-host factor interactions122025
R37AI039394Biochemical Mechanism of HIV DNA Integration112025
P30AI060354Harvard University Center for AIDS Research102025
R01AI100720Evolutionary potential of HIV-1 capsid: mechanisms and consequences92025
ZIABC010487The role of CPSF6 in HIV-1 infection92025
P30AI110527Tennessee Center for AIDS Research (TN-CFAR)82025
U54AI170855Behavior of HIV in Viral Environments (B-HIVE)82025

1 to 10 of 972Source NIH's project files

See all 972 nih grants

Papers1,298

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mechanistic Insights into HIV-1 Capsid Interactions with CPSF6.bioRxiv202642818617PubTator, text miningPubMed
Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harb Perspect Biol202642575696PubTator, text miningPubMed
Capsid stabilization reprograms the nuclear fate of the HIV genome.Sci Adv202642566516PubTator, text miningPubMed
Hiding in Plain Sight: HIV-1 Membraneless Organelles as Nuclear Hubs-Host Hijacking, Replication, Immune Evasion, and Drug-Access Implications.Pathogens202642515093PubTator, text miningPubMed
NUDT21 regulates 3'UTR dynamics in epididymal principal cells to preserve sperm integrity.Development202642381430PubTator, text miningPubMed
Hyperosmotic stress-induced redistribution of pre-mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation.FEBS Open Bio202642244075PubTator, text miningPubMed
Molecular mechanisms underlying liposarcoma subtype transition and proteasome-associated targeted interventions.J Transl Med202642192448PubTator, text miningPubMed
Novel HBx-interacting host cellular factors regulate dynamic nuclear and cytoplasmic localization of Hepatitis B virus X protein (HBx).Virology202642105427PubTator, text miningPubMed
Discovery of 4-Quinazolinone-Containing Phenylalanine Derivatives as Potent, Resistant-Tolerant HIV Capsid Inhibitors.MedComm (2020)202642087906PubTator, text miningPubMed
Block-and-Lock Approaches for HIV Cure: Mechanistic Insights, Challenges, and Emerging Role of CPSF6.Int J Mol Sci202642074139PubTator, text miningPubMed

1 to 10 of 1,298

See all 1,298 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/11052

GET https://conductscience.org/api/genes/v1/11052/patents