Gene · 11052
CPSF6: cleavage and polyadenylation specific factor 6
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CPSF6: cleavage and polyadenylation specific factor 6. Genes, record 11052. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11052
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16630 | Cleavage and polyadenylation specificity factor subunit 6 | 551 | 16 | Ensembl, GeneID, HGNC |
Source UniProt
Patents17
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 41671 | Q16630 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 12472 | Q16630 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 13683 | Q16630 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 13683 | Q16630 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 12472 | Q16630 | Espacenet |
| WO 2024240908 A1 | 2024-11-28 | 40 | Q16630 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 17677 | Q16630 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 120648 | Q16630 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 222106 | Q16630 | Espacenet |
| JP 2018153184 A | 2018-10-04 | 136 | Q16630 | Espacenet |
1 to 10 of 17
See all 17 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants972
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CPSF6 papers | Newest fiscal year |
|---|---|---|---|
| R01AI052014 | HIV-1 Preintegration Trafficking and Nuclear Localization | 41 | 2025 |
| R01AI120860 | Development of HIV capsid-targeting antivirals that affect immune response by modulating capsid stability and have improved resistance profiles | 14 | 2025 |
| U54AI170791 | Pittsburgh Center for HIV Protein Interactions (PCHPI) | 14 | 2025 |
| R01AI129862 | Imaging early steps of HIV-1 infection and virus-host factor interactions | 12 | 2025 |
| R37AI039394 | Biochemical Mechanism of HIV DNA Integration | 11 | 2025 |
| P30AI060354 | Harvard University Center for AIDS Research | 10 | 2025 |
| R01AI100720 | Evolutionary potential of HIV-1 capsid: mechanisms and consequences | 9 | 2025 |
| ZIABC010487 | The role of CPSF6 in HIV-1 infection | 9 | 2025 |
| P30AI110527 | Tennessee Center for AIDS Research (TN-CFAR) | 8 | 2025 |
| U54AI170855 | Behavior of HIV in Viral Environments (B-HIVE) | 8 | 2025 |
1 to 10 of 972Source NIH's project files
See all 972 nih grantsPapers1,298
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Mechanistic Insights into HIV-1 Capsid Interactions with CPSF6. | bioRxiv | 2026 | 42818617 | PubTator, text mining | PubMed |
| Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output. | Cold Spring Harb Perspect Biol | 2026 | 42575696 | PubTator, text mining | PubMed |
| Capsid stabilization reprograms the nuclear fate of the HIV genome. | Sci Adv | 2026 | 42566516 | PubTator, text mining | PubMed |
| Hiding in Plain Sight: HIV-1 Membraneless Organelles as Nuclear Hubs-Host Hijacking, Replication, Immune Evasion, and Drug-Access Implications. | Pathogens | 2026 | 42515093 | PubTator, text mining | PubMed |
| NUDT21 regulates 3'UTR dynamics in epididymal principal cells to preserve sperm integrity. | Development | 2026 | 42381430 | PubTator, text mining | PubMed |
| Hyperosmotic stress-induced redistribution of pre-mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation. | FEBS Open Bio | 2026 | 42244075 | PubTator, text mining | PubMed |
| Molecular mechanisms underlying liposarcoma subtype transition and proteasome-associated targeted interventions. | J Transl Med | 2026 | 42192448 | PubTator, text mining | PubMed |
| Novel HBx-interacting host cellular factors regulate dynamic nuclear and cytoplasmic localization of Hepatitis B virus X protein (HBx). | Virology | 2026 | 42105427 | PubTator, text mining | PubMed |
| Discovery of 4-Quinazolinone-Containing Phenylalanine Derivatives as Potent, Resistant-Tolerant HIV Capsid Inhibitors. | MedComm (2020) | 2026 | 42087906 | PubTator, text mining | PubMed |
| Block-and-Lock Approaches for HIV Cure: Mechanistic Insights, Challenges, and Emerging Role of CPSF6. | Int J Mol Sci | 2026 | 42074139 | PubTator, text mining | PubMed |
1 to 10 of 1,298
See all 1,298 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/11052
GET https://conductscience.org/api/genes/v1/11052/patents