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Gene · 1109

AKR1C4: aldo-keto reductase family 1 member C4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AKR1C4: aldo-keto reductase family 1 member C4. Genes, record 1109. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1109

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Gene

Symbol
AKR1C4
HGNC
Name
aldo-keto reductase family 1 member C4
HGNC
NCBI Gene ID
1109
NCBI Gene
HGNC ID
HGNC:387
HGNC
Ensembl
ENSG00000198610
NCBI Gene
Aliases
3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA, MGC22581
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17516Aldo-keto reductase family 1 member C43231Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437071P17516Espacenet
JP 2026004568 A2026-01-1437072P17516Espacenet
JP 2025081326 A2025-05-2738P17516Espacenet
JP 2025062604 A2025-04-143977P17516Espacenet
JP 2025062604 A2025-04-143978P17516Espacenet
JP 2025032204 A2025-03-1124366P17516Espacenet
JP 2025032204 A2025-03-1124367P17516Espacenet
JP 2025024198 A2025-02-199011P17516Espacenet
JP 2025024198 A2025-02-199012P17516Espacenet
EP 4461818 A22024-11-1324366P17516Espacenet

1 to 10 of 46

See all 46 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,309

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAKR1C4 papersNewest fiscal year
P30ES013508Center of Excellence in Environmental Toxicology522025
P30CA016520Abramson Cancer Center Support Grant72025
P30CA016672Cancer Center Support Grant52025
R01GM122923Characterizing the Regulation of Ferroptosis52025
P30AI064518Center for AIDS Research42025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)42025
P30CA015704Cancer Center Support Grant42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer32025
P30CA006973Regional Oncology Research Center32025

1 to 10 of 1,309Source NIH's project files

See all 1,309 nih grants

Papers1,988

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
KIAA1429 knockdown alleviates osteosarcoma progression by destabilizing SLC7A11 mRNA via m6A methylation to promote ferroptosis.Int J Oncol202642627048PubTator, text miningPubMed
Molecular insights into the high-efficiency catabolism of chloramphenicol for soil bioaugmentation by Nocardia testacea CS1.Eco Environ Health202642502616PubTator, text miningPubMed
Reduction of secondary 3-keto bile acids by aldo-keto reductase 1C1 and 1C4.Drug Metab Dispos202642401153PubTator, text miningPubMed
Novel 10-Alkoxy 1,4-Dien-3-One Estranes as Multitarget Anticancer Agents Against Estrogen-Positive Breast Cancer.Chem Biol Drug Des202642190048PubTator, text miningPubMed
Lipid metabolism-related gene expression predicts prognostic outcomes in lung adenocarcinoma.Transl Cancer Res202642180928PubTator, text miningPubMed
Bioactivities of Alchemilla alpina L. Extract on Women's Reproductive and Metabolic Health: Antioxidant, Enzyme Inhibitory, Receptor Modulatory Properties and Potential Cytotoxic Effects.Int J Mol Sci202641977214PubTator, text miningPubMed
Age-related downregulation of dihydrotestosterone-inactivating enzymes in human scalp sebaceous glands.Inflamm Regen202641943039PubTator, text miningPubMed
Targeting SPP1 +TAMs associated with liver metastasis reverses immunosuppression and synergizes with immunotherapy in colorectal cancer.J Immunother Cancer202641881501PubTator, text miningPubMed
Proteomic characterization of intrahepatic cholangiocarcinoma identifies risk-stratifying subgroups and EIF4A1 as a therapeutic target.Nat Commun202641872184PubTator, text miningPubMed
Global molecular landscape of early MASLD progression in human obesity.Elife202641870035PubTator, text miningPubMed

1 to 10 of 1,988

See all 1,988 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1109

GET https://conductscience.org/api/genes/v1/1109/patents?page=2