Gene · 1109
AKR1C4: aldo-keto reductase family 1 member C4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. AKR1C4: aldo-keto reductase family 1 member C4. Genes, record 1109. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1109
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P17516 | Aldo-keto reductase family 1 member C4 | 323 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents46
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 37071 | P17516 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 37072 | P17516 | Espacenet |
| JP 2025081326 A | 2025-05-27 | 38 | P17516 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3977 | P17516 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3978 | P17516 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 24366 | P17516 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 24367 | P17516 | Espacenet |
| JP 2025024198 A | 2025-02-19 | 9011 | P17516 | Espacenet |
| JP 2025024198 A | 2025-02-19 | 9012 | P17516 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 24366 | P17516 | Espacenet |
1 to 10 of 46
See all 46 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,309
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | AKR1C4 papers | Newest fiscal year |
|---|---|---|---|
| P30ES013508 | Center of Excellence in Environmental Toxicology | 52 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| R01GM122923 | Characterizing the Regulation of Ferroptosis | 5 | 2025 |
| P30AI064518 | Center for AIDS Research | 4 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 4 | 2025 |
| ZIACP010121 | Molecular Epidemiology Studies of Occupational and Environmental Exposures | 4 | 2025 |
| P01CA163227 | Androgen Receptor Action in Castration Resistant Prostate Cancer | 3 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
1 to 10 of 1,309Source NIH's project files
See all 1,309 nih grantsPapers1,988
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| KIAA1429 knockdown alleviates osteosarcoma progression by destabilizing SLC7A11 mRNA via m6A methylation to promote ferroptosis. | Int J Oncol | 2026 | 42627048 | PubTator, text mining | PubMed |
| Molecular insights into the high-efficiency catabolism of chloramphenicol for soil bioaugmentation by Nocardia testacea CS1. | Eco Environ Health | 2026 | 42502616 | PubTator, text mining | PubMed |
| Reduction of secondary 3-keto bile acids by aldo-keto reductase 1C1 and 1C4. | Drug Metab Dispos | 2026 | 42401153 | PubTator, text mining | PubMed |
| Novel 10-Alkoxy 1,4-Dien-3-One Estranes as Multitarget Anticancer Agents Against Estrogen-Positive Breast Cancer. | Chem Biol Drug Des | 2026 | 42190048 | PubTator, text mining | PubMed |
| Lipid metabolism-related gene expression predicts prognostic outcomes in lung adenocarcinoma. | Transl Cancer Res | 2026 | 42180928 | PubTator, text mining | PubMed |
| Bioactivities of Alchemilla alpina L. Extract on Women's Reproductive and Metabolic Health: Antioxidant, Enzyme Inhibitory, Receptor Modulatory Properties and Potential Cytotoxic Effects. | Int J Mol Sci | 2026 | 41977214 | PubTator, text mining | PubMed |
| Age-related downregulation of dihydrotestosterone-inactivating enzymes in human scalp sebaceous glands. | Inflamm Regen | 2026 | 41943039 | PubTator, text mining | PubMed |
| Targeting SPP1 +TAMs associated with liver metastasis reverses immunosuppression and synergizes with immunotherapy in colorectal cancer. | J Immunother Cancer | 2026 | 41881501 | PubTator, text mining | PubMed |
| Proteomic characterization of intrahepatic cholangiocarcinoma identifies risk-stratifying subgroups and EIF4A1 as a therapeutic target. | Nat Commun | 2026 | 41872184 | PubTator, text mining | PubMed |
| Global molecular landscape of early MASLD progression in human obesity. | Elife | 2026 | 41870035 | PubTator, text mining | PubMed |
1 to 10 of 1,988
See all 1,988 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1109
GET https://conductscience.org/api/genes/v1/1109/patents?page=2