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ADAMTS13: ADAM metallopeptidase with thrombospondin type 1 motif 13

1 protein, 109 patents, 1 drug, 6 trials, 1,388 NIH grants and 6,933 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolADAMTS13HGNC
NameADAM metallopeptidase with thrombospondin type 1 motif 13HGNC
NCBI Gene ID11093NCBI Gene
HGNC IDHGNC:1366HGNC
EnsemblENSG00000160323NCBI Gene
AliasesADAM-TS13, ADAMTS-13, C9orf8, DKFZp434C2322, FLJ42993, MGC118899, MGC118900, TTP, VWFCP, vWF-CPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q76LX8A disintegrin and metalloproteinase with thrombospondin motifs 131,4275Ensembl, GeneID, HGNCUniProt

Patents 109

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026177128 A2026-08-27194Q76LX8Espacenet
JP 2026067851 A2026-04-21381Q76LX8Espacenet
JP 2025541179 A2025-12-1835Q76LX8Espacenet
JP 2025539844 A2025-12-0966Q76LX8Espacenet
JP 2025169942 A2025-11-14773Q76LX8Espacenet
JP 2025169942 A2025-11-14785Q76LX8Espacenet
EP 4641201 A22025-10-299295Q76LX8Espacenet
EP 4630459 A12025-10-1535Q76LX8Espacenet
JP 2025147176 A2025-10-06332Q76LX8Espacenet
JP 2025529142 A2025-09-045385Q76LX8Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APADAMTASE ALFACHEMBL4594607A disintegrin and metalloproteinase with thrombospondin motifs 13 exogenous proteinEXOGENOUS PROTEINChEMBL

Trials 6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06441578APADAMTASE ALFAClinicalTrials.gov
NCT05770219APADAMTASE ALFAClinicalTrials.gov
NCT04683003APADAMTASE ALFAPHASE3ClinicalTrials.gov
NCT03997760APADAMTASE ALFAPHASE12024-04-23ClinicalTrials.gov
NCT03922308APADAMTASE ALFAPHASE22022-12-01ClinicalTrials.gov
NCT03393975APADAMTASE ALFAPHASE32025-03-19ClinicalTrials.gov

NIH grants 1388

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL157975Mechanism underlying cofactor-dependent proteolysis of von Willebrand Factor132,025NIH's project files
R01GM108618Inflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure Renewal102,025NIH's project files
U54GM104938Oklahoma Shared Clinical and Translational Resources102,025NIH's project files
R01HL164016Pathogenesis of thrombotic microangiopathies82,025NIH's project files
T32HL007971Training grant in hemostasis and thrombosis82,025NIH's project files
P30CA016672Cancer Center Support Grant62,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI62,025NIH's project files
T32HL007093Hematology Training62,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award62,025NIH's project files
ZIABC010301Development of Recombinant Toxins to Treat Hematologic Malignancies62,025NIH's project files

Papers 6933

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827462PubTator, text miningPubMed
42823207PubTator, text miningPubMed
42819333PubTator, text miningPubMed
42812790PubTator, text miningPubMed
42809927PubTator, text miningPubMed
42809655PubTator, text miningPubMed
42808878PubTator, text miningPubMed
42796720PubTator, text miningPubMed
42792819PubTator, text miningPubMed
42789934PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license