ConductScience.org, home

Gene · 11096

ADAMTS5: ADAM metallopeptidase with thrombospondin type 1 motif 5

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. ADAMTS5: ADAM metallopeptidase with thrombospondin type 1 motif 5. Genes, record 11096. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11096

On this page

Gene

Symbol
ADAMTS5
HGNC
Name
ADAM metallopeptidase with thrombospondin type 1 motif 5
HGNC
NCBI Gene ID
11096
NCBI Gene
HGNC ID
HGNC:221
HGNC
Ensembl
ENSG00000154736
NCBI Gene
Aliases
ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UNA0A disintegrin and metalloproteinase with thrombospondin motifs 59308Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026102819 A2026-06-23149Q9UNA0Espacenet
EP 4729612 A22026-04-2267Q9UNA0Espacenet
JP 2026004568 A2026-01-1436462Q9UNA0Espacenet
EP 4650780 A22025-11-193243Q9UNA0Espacenet
EP 4641201 A22025-10-292818Q9UNA0Espacenet
JP 2025147176 A2025-10-06362Q9UNA0Espacenet
JP 2025529142 A2025-09-045395Q9UNA0Espacenet
US 12371689 B22025-07-295395Q9UNA0Espacenet
EP 4583904 A12025-07-16140Q9UNA0Espacenet
JP 2025517969 A2025-06-122818Q9UNA0Espacenet

1 to 10 of 60

See all 60 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ALDUMASTATCHEMBL4650334ADAMTS5 inhibitorINHIBITOR

Source ChEMBL

Trials2

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03595618ALDUMASTATPHASE22021-05-12ClinicalTrials.gov
NCT03311009ALDUMASTATPHASE1ClinicalTrials.gov

NIH grants963

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADAMTS5 papersNewest fiscal year
R01AR060364Molecular Pathways of Pain Generation in Osteoarthritis72025
R01AG044034Oxidative Stress and the Development of Osteoarthritis62025
P30AR074992RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE52025
R01AR064251Osteoarthritis Progression And Sensory Pathway Alterations52025
P30AG028716Duke Claude D. Pepper Older Americans Independence Center42025
P30AR073752Washington University Rheumatic Diseases Research Resource-based Center42025
P30EY010572Ophthalmology Core Facility42025
T32AR060719Skeletal Disorders Training Program42025
P30CA016087Cancer Center Support Grant32025
R01HL160802Proteoglycan Metabolism During Cardiac Valve Development and Disease32025

1 to 10 of 963Source NIH's project files

See all 963 nih grants

Papers3,260

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Hierarchical Nanorocket for spatially coordinated regulation of glycosaminoglycan deposition and metabolism in cartilage.Bioact Mater202742733560PubTator, text miningPubMed
Punicic acid alleviates osteoarthritis progression through miR-29a-3p-dependent inhibition of the MAP2K6/p38 MAPK pathway.In Vitro Cell Dev Biol Anim202642747754PubTator, text miningPubMed
Donor-dependent heterogeneity and matrix-remodeling transcriptional programs in COL2A1-variant urine-derived cell cultures with IGF1-associated cell-state shifts.Front Cell Dev Biol202642745831PubTator, text miningPubMed
Rivaroxaban suppresses factor Xa-Driven PAR-2-ERK inflammatory, catabolic, osteoclastogenic, and mitochondrial dysfunction signaling in osteoarthritis-relevant chondrocytes: a drug-repurposing strategy for joint inflammation.
Front Pharmacol202642741326PubTator, text miningPubMed
Synovial fluid and serum levels of a disintegrin and metalloproteinase with thrombospondin motifs 5 are associated with the severity of primary knee osteoarthritis.Clin Biomech (Bristol)202642731244PubTator, text miningPubMed
Eugenol preserves chondrocyte extracellular matrix homeostasis by modulating the ALK1/ALK5-associated TGF-β/Smad signaling axis.Front Pharmacol202642723961PubTator, text miningPubMed
In vitro evaluation of hydroxyapatite, β-tricalcium phosphate, graphene oxide and zinc oxide for osteochondral regeneration under inflammatory conditions.Mol Cell Biochem202642709332PubTator, text miningPubMed
Early mRNA expression of pro-inflammatory cytokines and ADAMTS-5 in an acute ischemia/reperfusion-induced pressure ulcer model, a pilot exploratory animal study.Turk J Phys Med Rehabil202642682030PubTator, text miningPubMed
Plasma miR-148b-3p is associated with CKD-related renal dysfunction and carotid plaque burden in patients with established coronary artery disease.Front Cardiovasc Med202642656636PubTator, text miningPubMed
Physiological Lipid Palmitoylcarnitine Constrains Factor Xa Signalling Through PAR-2 to Attenuate ERK-Driven Inflammation and Preserve Mitochondrial Membrane Potential in Chondrocytes.Biomedicines202642652063PubTator, text miningPubMed

1 to 10 of 3,260

See all 3,260 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/11096

GET https://conductscience.org/api/genes/v1/11096/patents?page=2