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Gene · 111

ADCY5: adenylate cyclase 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADCY5: adenylate cyclase 5. Genes, record 111. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/111

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Gene

Symbol
ADCY5
HGNC
Name
adenylate cyclase 5
HGNC
NCBI Gene ID
111
NCBI Gene
HGNC ID
HGNC:236
HGNC
Ensembl
ENSG00000173175
NCBI Gene
Aliases
AC5, DSKOD, FDFM
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95622Adenylate cyclase type 51,2612Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436696O95622Espacenet
EP 4641201 A22025-10-2916748O95622Espacenet
JP 2025529142 A2025-09-04290O95622Espacenet
US 12371689 B22025-07-29290O95622Espacenet
JP 2025517969 A2025-06-1216748O95622Espacenet
JP 2025062604 A2025-04-142814O95622Espacenet
EP 4220176 A22023-08-0222O95622Espacenet
JP 2022160535 A2022-10-1922O95622Espacenet
US 11446398 B22022-09-202814O95622Espacenet
US 11400116 B22022-08-026706O95622Espacenet

1 to 10 of 20

See all 20 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,531

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADCY5 papersNewest fiscal year
ZIAHG000024Genetic analysis of type II diabetes162025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION132025
P30DK020572Michigan Diabetes Research Center (MDRC)122025
P30DK063491Diabetes Research Center (DRC)102025
R01DK093757Genetic epidemiology of rare and regulatory variants for metabolic traits102025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal82025
ZIADA000493Functional and Pharmacological Significance of Receptor Heteromers in the CNS82025
UL1TR001881UCLA Clinical and Translational Science Institute52025
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases42025
R01DK075787Biological Insights from Genetic Investigation of ANthropometric Traits (GIANT) Across the Allelic Spectrum42025

1 to 10 of 1,531Source NIH's project files

See all 1,531 nih grants

Papers1,453

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
High-throughput phenotypic screening identifies the phytochemical melissic acid that mitigates SHED cellular senescence via the ADCY5/cAMP/CREB axis.Front Pharmacol202642824422PubTator, text miningPubMed
Adenylyl cyclase 9 as a molecular scaffold to dissect the mechanisms of membrane adenylyl cyclases.Protein Sci202642752937PubTator, text miningPubMed
Novel and Emerging Therapies for Childhood-Onset Movement Disorders.Mov Disord202642723627PubTator, text miningPubMed
Annexin A4 Deficient Ventricular Myocytes Display Advanced Hypertrophy and Electrical Remodeling With Chronic β-Adrenoceptor Stimulation.FASEB J202642684683PubTator, text miningPubMed
Phylogeographic Structure and Molecular Evolution of Squash Leaf Curl China Virus.Viruses202642515646PubTator, text miningPubMed
Relative Efficacy of Self-Managed Caffeine Supplementation in Maintaining Daily Activity in a Patient with ADCY5-Related Dyskinesia: A Case Report.Case Rep Neurol202642422538PubTator, text miningPubMed
ADCY2, ADCY5, and GRIA1 as key genes of the cAMP signaling pathway in osteoporotic spinal fracture after manipulation of Wnt signaling.Arch Med Sci202642305321PubTator, text miningPubMed
Maternal Genetic Variants and Gestational Duration: A Replication Study in a Japanese Cohort.J Clin Med202642279130PubTator, text miningPubMed
Parkinsonism in Childhood, a Clue to Autosomal Recessive ADCY5-Related Movement Disorder?Mov Disord Clin Pract202642120309PubTator, text miningPubMed
Distinct Brain Drivers and Shared Cerebello-Cortical Input in ADCY5 and SGCE Hyperkinetic Movements.Mov Disord202642063207PubTator, text miningPubMed

1 to 10 of 1,453

See all 1,453 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/111

GET https://conductscience.org/api/genes/v1/111/patents