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CHEK1: checkpoint kinase 1

1 protein, 88 patents, 9 drugs, 41 trials, 6,728 NIH grants and 15,449 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCHEK1HGNC
Namecheckpoint kinase 1HGNC
NCBI Gene ID1111NCBI Gene
HGNC IDHGNC:1925HGNC
EnsemblENSG00000149554NCBI Gene
AliasesCHK1, OZEMA21NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O14757Serine/threonine-protein kinase Chk1476164Ensembl, GeneID, HGNCUniProt

Patents 88

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4640238 A12025-10-295O14757Espacenet
EP 4641202 A22025-10-296154O14757Espacenet
US 12433888 B12025-10-071O14757Espacenet
EP 4555325 A22025-05-211O14757Espacenet
KR 1020250017231 A2025-02-046154O14757Espacenet
JP 2024123008 A2024-09-105549O14757Espacenet
JP 2024123008 A2024-09-105550O14757Espacenet
JP 2024123008 A2024-09-105551O14757Espacenet
JP 2024123008 A2024-09-105556O14757Espacenet
EP 4400117 A12024-07-175O14757Espacenet

Drugs 9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZD-7762CHEMBL2041933Serine/threonine-protein kinase Chk1 inhibitorINHIBITORChEMBL
PF-00477736CHEMBL3545137Serine/threonine-protein kinase Chk1 inhibitorINHIBITORChEMBL
PREXASERTIBCHEMBL3544911Serine/threonine-protein kinase Chk1 inhibitorINHIBITORChEMBL
RABUSERTIBCHEMBL3039517Serine/threonine-protein kinase Chk1 inhibitorINHIBITORChEMBL
RG-7602CHEMBL5314388Serine/threonine-protein kinase Chk1 inhibitorINHIBITORChEMBL
RG-7741CHEMBL3545199Serine/threonine-protein kinase Chk1 inhibitorINHIBITORChEMBL
SCH-900776CHEMBL2386889Serine/threonine-protein kinase Chk1 inhibitorINHIBITORChEMBL
UCN-01CHEMBL574737Serine/threonine-protein kinase Chk1 inhibitorINHIBITORChEMBL
XL-844CHEMBL3544936Serine/threonine-protein kinase Chk1 inhibitorINHIBITORChEMBL

Trials 41

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06597565PREXASERTIBPHASE2ClinicalTrials.gov
NCT05548296PREXASERTIBPHASE2ClinicalTrials.gov
NCT04095221PREXASERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT04032080PREXASERTIBPHASE22023-09-11ClinicalTrials.gov
NCT04023669PREXASERTIBPHASE1ClinicalTrials.gov
NCT03735446PREXASERTIBPHASE1ClinicalTrials.gov
NCT03414047PREXASERTIBPHASE22020-06-17ClinicalTrials.gov
NCT02860780PREXASERTIBPHASE1ClinicalTrials.gov
NCT02808650PREXASERTIBPHASE12023-12-20ClinicalTrials.gov
NCT02735980PREXASERTIBPHASE22020-03-17ClinicalTrials.gov

NIH grants 6728

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2052,025NIH's project files
P30CA008748Cancer Center Support Grant1042,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility432,025NIH's project files
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs422,025NIH's project files
P30CA016086Cancer Center Support Grant362,025NIH's project files
P30CA047904Cancer Center Support Grant362,025NIH's project files
P30CA016058Cancer Center Support Grant322,025NIH's project files
P30CA006973Regional Oncology Research Center312,025NIH's project files
P30CA023108Cancer Center Support Grant312,025NIH's project files
P01CA092584Structural Cell Biology of DNA Repair Machines282,025NIH's project files

Papers 15449

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823720PubTator, text miningPubMed
42819173PubTator, text miningPubMed
42817718PubTator, text miningPubMed
42811518PubTator, text miningPubMed
42800881PubTator, text miningPubMed
42797298PubTator, text miningPubMed
42794728PubTator, text miningPubMed
42786371PubTator, text miningPubMed
42779662PubTator, text miningPubMed
42773173PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license