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CHEK2: checkpoint kinase 2

1 protein, 119 patents, 2 drugs, 16 trials, 7,448 NIH grants and 17,170 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCHEK2HGNC
Namecheckpoint kinase 2HGNC
NCBI Gene ID11200NCBI Gene
HGNC IDHGNC:16627HGNC
EnsemblENSG00000183765NCBI Gene
AliasesCDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, TPDS4, bA444G7, hCds1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O96017Serine/threonine-protein kinase Chk254338Ensembl, GeneID, HGNCUniProt

Patents 119

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1911956O96017Espacenet
EP 4640849 A22025-10-291924O96017Espacenet
EP 4641201 A22025-10-2912810O96017Espacenet
EP 4641202 A22025-10-29689O96017Espacenet
US 12433888 B12025-10-072O96017Espacenet
JP 2025147176 A2025-10-062751O96017Espacenet
JP 2025147176 A2025-10-062753O96017Espacenet
JP 2025147176 A2025-10-062755O96017Espacenet
JP 2025529142 A2025-09-04918O96017Espacenet
JP 2025529142 A2025-09-045855O96017Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PREXASERTIBCHEMBL3544911Serine/threonine-protein kinase Chk2 inhibitorINHIBITORChEMBL
XL-844CHEMBL3544936Serine/threonine-protein kinase Chk2 inhibitorINHIBITORChEMBL

Trials 16

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06597565PREXASERTIBPHASE2ClinicalTrials.gov
NCT05548296PREXASERTIBPHASE2ClinicalTrials.gov
NCT04095221PREXASERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT04032080PREXASERTIBPHASE22023-09-11ClinicalTrials.gov
NCT04023669PREXASERTIBPHASE1ClinicalTrials.gov
NCT03735446PREXASERTIBPHASE1ClinicalTrials.gov
NCT03414047PREXASERTIBPHASE22020-06-17ClinicalTrials.gov
NCT02860780PREXASERTIBPHASE1ClinicalTrials.gov
NCT02808650PREXASERTIBPHASE12023-12-20ClinicalTrials.gov
NCT02735980PREXASERTIBPHASE22020-03-17ClinicalTrials.gov

NIH grants 7448

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2282,025NIH's project files
P30CA016672Cancer Center Support Grant2032,025NIH's project files
P50CA116201Mayo Clinic Breast Cancer SPORE662,025NIH's project files
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs442,025NIH's project files
P30CA006973Regional Oncology Research Center422,025NIH's project files
P30CA016058Cancer Center Support Grant382,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant352,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant342,025NIH's project files
P30CA015704Cancer Center Support Grant332,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)322,025NIH's project files

Papers 17170

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821141PubTator, text miningPubMed
42811745PubTator, text miningPubMed
42809932PubTator, text miningPubMed
42806037PubTator, text miningPubMed
42800309PubTator, text miningPubMed
42800083PubTator, text miningPubMed
42783913PubTator, text miningPubMed
42782902PubTator, text miningPubMed
42763930PubTator, text miningPubMed
42759617PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license