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Gene · 11201

POLI: DNA polymerase iota

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. POLI: DNA polymerase iota. Genes, record 11201. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11201

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Gene

Symbol
POLI
HGNC
Name
DNA polymerase iota
HGNC
NCBI Gene ID
11201
NCBI Gene
HGNC ID
HGNC:9182
HGNC
Ensembl
ENSG00000101751
NCBI Gene
Aliases
RAD30B, RAD3OB, eta2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UNA4DNA polymerase iota74054Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458424Q9UNA4Espacenet
JP 2026004568 A2026-01-1458426Q9UNA4Espacenet
US 12497601 B22025-12-161164Q9UNA4Espacenet
US 12497601 B22025-12-161237Q9UNA4Espacenet
EP 4641201 A22025-10-2921544Q9UNA4Espacenet
US 12435331 B22025-10-0758Q9UNA4Espacenet
US 12415993 B22025-09-161164Q9UNA4Espacenet
US 12415993 B22025-09-161237Q9UNA4Espacenet
JP 2025517969 A2025-06-1221544Q9UNA4Espacenet
EP 4551698 A12025-05-1411Q9UNA4Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,779

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePOLI papersNewest fiscal year
ZIAHD001500DNA Replication, Repair, and Mutagenesis In Eukaryotic And Prokaryotic Cells382025
P30CA006973Regional Oncology Research Center182025
ZIAES065070Structure-Function Studies Of DNA Replication Fidelity92025
R35GM140710UNDERSTANDING THE ROLES OF RNA POLYMERASE I IN TRANSCRIPTION AND BEYOND82025
P30CA016672Cancer Center Support Grant72025
R01GM141033New Paradigms for the molecular basis of RNA polymerase I transcription72025
P30CA013148Comprehensive Cancer Center Support Grant62025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
R01GM089846Role of DNA structural dynamics in mutagenesis and oncogenesis62025
P01CA092584Structural Cell Biology of DNA Repair Machines52025

1 to 10 of 1,779Source NIH's project files

See all 1,779 nih grants

Papers2,750

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
JP-1302 inhibits RNA polymerase I transcription and induces nucleolar stress in cancer cell lines.Cell Death Discov202642816485PubTator, text miningPubMed
Ribosomal RNA transcription in normal and leukemic hematopoiesis.Curr Top Dev Biol202642754314PubTator, text miningPubMed
RNA polymerase II removal: transcription quality control and gene regulation.Transcription202642633709PubTator, text miningPubMed
Polymerase ι promotes C>T substitutions in smoking models and in the platinum chemotherapy-induced SBS31 mutation signature.Proc Natl Acad Sci U S A202642561022PubTator, text miningPubMed
RAD54L coordinates the nucleolar DNA damage response to maintain rDNA stability.EMBO J202642493648PubTator, text miningPubMed
Silencing of human RNA polymerase I subunit A34 influences multiple cellular processes including rDNA transcription and cell migration.Int J Biol Macromol202642372890PubTator, text miningPubMed
Dynamic positioning of Rpc34 winged helix in RNA polymerase III elongation complex for its stability with implications for reinitiation.Proc Natl Acad Sci U S A202642372135PubTator, text miningPubMed
Association of DNA damage repair related genes with prostate cancer: A multi-omics Mendelian Randomization analysis.Medicine (Baltimore)202642216412PubTator, text miningPubMed
Nucleolar expansion: A biomolecular condensate mortality timer.Geromedicine202642016362PubTator, text miningPubMed
Co-Transfected Plasmids Enhance Transient Expression of Reporter Genes.BioTech (Basel)202641892150PubTator, text miningPubMed

1 to 10 of 2,750

See all 2,750 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/11201

GET https://conductscience.org/api/genes/v1/11201/patents?page=2