Gene · 11201
POLI: DNA polymerase iota
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. POLI: DNA polymerase iota. Genes, record 11201. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11201
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UNA4 | DNA polymerase iota | 740 | 54 | Ensembl, GeneID, HGNC |
Source UniProt
Patents35
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58424 | Q9UNA4 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58426 | Q9UNA4 | Espacenet |
| US 12497601 B2 | 2025-12-16 | 1164 | Q9UNA4 | Espacenet |
| US 12497601 B2 | 2025-12-16 | 1237 | Q9UNA4 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 21544 | Q9UNA4 | Espacenet |
| US 12435331 B2 | 2025-10-07 | 58 | Q9UNA4 | Espacenet |
| US 12415993 B2 | 2025-09-16 | 1164 | Q9UNA4 | Espacenet |
| US 12415993 B2 | 2025-09-16 | 1237 | Q9UNA4 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 21544 | Q9UNA4 | Espacenet |
| EP 4551698 A1 | 2025-05-14 | 11 | Q9UNA4 | Espacenet |
1 to 10 of 35
See all 35 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,779
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | POLI papers | Newest fiscal year |
|---|---|---|---|
| ZIAHD001500 | DNA Replication, Repair, and Mutagenesis In Eukaryotic And Prokaryotic Cells | 38 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 18 | 2025 |
| ZIAES065070 | Structure-Function Studies Of DNA Replication Fidelity | 9 | 2025 |
| R35GM140710 | UNDERSTANDING THE ROLES OF RNA POLYMERASE I IN TRANSCRIPTION AND BEYOND | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| R01GM141033 | New Paradigms for the molecular basis of RNA polymerase I transcription | 7 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 6 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 6 | 2025 |
| R01GM089846 | Role of DNA structural dynamics in mutagenesis and oncogenesis | 6 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 5 | 2025 |
1 to 10 of 1,779Source NIH's project files
See all 1,779 nih grantsPapers2,750
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| JP-1302 inhibits RNA polymerase I transcription and induces nucleolar stress in cancer cell lines. | Cell Death Discov | 2026 | 42816485 | PubTator, text mining | PubMed |
| Ribosomal RNA transcription in normal and leukemic hematopoiesis. | Curr Top Dev Biol | 2026 | 42754314 | PubTator, text mining | PubMed |
| RNA polymerase II removal: transcription quality control and gene regulation. | Transcription | 2026 | 42633709 | PubTator, text mining | PubMed |
| Polymerase ι promotes C>T substitutions in smoking models and in the platinum chemotherapy-induced SBS31 mutation signature. | Proc Natl Acad Sci U S A | 2026 | 42561022 | PubTator, text mining | PubMed |
| RAD54L coordinates the nucleolar DNA damage response to maintain rDNA stability. | EMBO J | 2026 | 42493648 | PubTator, text mining | PubMed |
| Silencing of human RNA polymerase I subunit A34 influences multiple cellular processes including rDNA transcription and cell migration. | Int J Biol Macromol | 2026 | 42372890 | PubTator, text mining | PubMed |
| Dynamic positioning of Rpc34 winged helix in RNA polymerase III elongation complex for its stability with implications for reinitiation. | Proc Natl Acad Sci U S A | 2026 | 42372135 | PubTator, text mining | PubMed |
| Association of DNA damage repair related genes with prostate cancer: A multi-omics Mendelian Randomization analysis. | Medicine (Baltimore) | 2026 | 42216412 | PubTator, text mining | PubMed |
| Nucleolar expansion: A biomolecular condensate mortality timer. | Geromedicine | 2026 | 42016362 | PubTator, text mining | PubMed |
| Co-Transfected Plasmids Enhance Transient Expression of Reporter Genes. | BioTech (Basel) | 2026 | 41892150 | PubTator, text mining | PubMed |
1 to 10 of 2,750
See all 2,750 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/11201
GET https://conductscience.org/api/genes/v1/11201/patents?page=2