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Gene · 11277

TREX1: three prime repair exonuclease 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TREX1: three prime repair exonuclease 1. Genes, record 11277. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11277

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Gene

Symbol
TREX1
HGNC
Name
three prime repair exonuclease 1
HGNC
NCBI Gene ID
11277
NCBI Gene
HGNC ID
HGNC:12269
HGNC
Ensembl
ENSG00000213689
NCBI Gene
Aliases
AGS1, CRV, DRN3, HERNS, RVCLS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NSU2Three-prime repair exonuclease 131412Ensembl, GeneID, HGNC

Source UniProt

Patents64

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4777634 A12026-07-228Q9NSU2Espacenet
JP 2026515744 A2026-05-1977Q9NSU2Espacenet
EP 4650780 A22025-11-1918997Q9NSU2Espacenet
JP 2025529142 A2025-09-045053Q9NSU2Espacenet
US 12371689 B22025-07-295053Q9NSU2Espacenet
JP 2025517970 A2025-06-1218997Q9NSU2Espacenet
JP 2025062604 A2025-04-147857Q9NSU2Espacenet
EP 4522737 A22025-03-1952Q9NSU2Espacenet
EP 4466346 A22024-11-27939Q9NSU2Espacenet
WO 2024214081 A12024-10-1777Q9NSU2Espacenet

1 to 10 of 64

See all 64 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,852

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTREX1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant182025
P30CA012197Cancer Center Support Grant142025
P30CA016672Cancer Center Support Grant112025
R01AI024717Genetic Linkage in Lupus92025
ZIAAI001220Pathogenesis, and Outcome of Autoinflammatory Diseases, NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and other Undifferentiated Autoinflammatory Diseases82025
R01CA201246Cancer Cell Intrinsic Interferon-I pathway Activation by Fractionated Radiation72025
P01AG051449Role of Retrotransposon Activity in Neurodegeneration and Alzheimer's Disease62025
R01AI143982Mechanisms of STING-associated autoinflammation62025
R37CA261183Immune control and genomic instability at micronuclei62025
T32AI007401Training Program in Immunology and Pathogenesis62025

1 to 10 of 1,852Source NIH's project files

See all 1,852 nih grants

Papers2,317

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The evolving role of radiotherapy in oligometastatic pancreatic cancer: from palliation to disease-modifying multidisciplinary integration.Front Oncol202642769899PubTator, text miningPubMed
ACTA2-directed actin filaments license STING trafficking and activation for antiviral immunity and autoimmune pathogenesis.Proc Natl Acad Sci U S A202642743285PubTator, text miningPubMed
Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease.Clin Genet202642661427PubTator, text miningPubMed
Type I Interferonopathies in the Differential Diagnosis of Vasculitis: A Comprehensive Review.J Vis Exp202642611810PubTator, text miningPubMed
Immune response to DNA and RNA: structural insights, molecular mechanisms, and therapeutic targeting.Mol Biomed202642557506PubTator, text miningPubMed
Whole-exome sequencing identifies matrisomal gene associations in monogenic cerebral small vessel disease.J Neurol202642481886PubTator, text miningPubMed
Extracellular Traps in Coronary Thrombus Aspirates from Patients with ST-Elevation Myocardial Infarction.Int J Mol Sci202642450266PubTator, text miningPubMed
Selective targeting of human TREX1 exonuclease by small molecule inhibitors is mediated by a conformational switch.NAR Mol Med202642441291PubTator, text miningPubMed
Genetic landscape of early-onset systemic lupus erythematous in India.Rheumatology (Oxford)202642251732PubTator, text miningPubMed
Rational design of carbazole-based STING inhibitors for treating cGAS-STING pathway-driven inflammatory disorders.Nat Commun202642230579PubTator, text miningPubMed

1 to 10 of 2,317

See all 2,317 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/11277

GET https://conductscience.org/api/genes/v1/11277/patents?page=2