Gene · 11284
PNKP: polynucleotide kinase 3'-phosphatase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PNKP: polynucleotide kinase 3'-phosphatase. Genes, record 11284. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11284
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96T60 | Bifunctional polynucleotide phosphatase/kinase | 521 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents41
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026509506 A | 2026-03-19 | 101 | Q96T60 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 5500 | Q96T60 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 5500 | Q96T60 | Espacenet |
| WO 2025080780 A1 | 2025-04-17 | 101 | Q96T60 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 296 | Q96T60 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 7796 | Q96T60 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 296 | Q96T60 | Espacenet |
| JP 2023514149 A | 2023-04-05 | 130 | Q96T60 | Espacenet |
| KR 1020220141829 A | 2022-10-20 | 101 | Q96T60 | Espacenet |
| KR 1020220133109 A | 2022-10-04 | 9 | Q96T60 | Espacenet |
1 to 10 of 41
See all 41 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,363
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PNKP papers | Newest fiscal year |
|---|---|---|---|
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 63 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 21 | 2025 |
| RM1HG008935 | Center for dynamic RNA epitranscriptomes - Renewal | 12 | 2025 |
| ZIABC006150 | DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs | 12 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| R01ES012512 | Roles of Lig3 and XRCC1 Genes in Genome Stability | 9 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 8 | 2025 |
| P30CA077598 | Cancer Center Support Grant | 7 | 2025 |
| ZIABC006161 | DNA Topoisomerases as nuclear and mitochondrial targets of Anticancer Drugs | 7 | 2025 |
| P01CA096832 | NORMAL & NEOPLASTIC GROWTH IN THE BRAIN | 6 | 2025 |
1 to 10 of 2,363Source NIH's project files
See all 2,363 nih grantsPapers2,557
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Structural insights into RNA phosphorylation by the RNase PNK module of the human rixosome complex. | Nucleic Acids Res | 2026 | 42708412 | PubTator, text mining | PubMed |
| Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer. | Front Syst Biol | 2026 | 42630458 | PubTator, text mining | PubMed |
| Colorimetric Detection and Intracellular Imaging of Polynucleotide Kinase by the Phosphorylation-Induced Assembly of DNA-Modified Gold Nanoparticles. | Anal Chem | 2026 | 42432832 | PubTator, text mining | PubMed |
| Double-Strand Gated Biosensor for Ultrasensitive T4 PNK Detection via λ-Exonuclease-Driven Background Suppression and Dimer G-Triplex Signal Amplification. | ACS Sens | 2026 | 42396923 | PubTator, text mining | PubMed |
| The MLLT3 YEATS domain binds histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking transcription and RNA signaling to regulate hematopoiesis. | Cell Rep | 2026 | 42268713 | PubTator, text mining | PubMed |
| Integrative multi-omics analysis identifies endocrine-disrupting chemical-related molecular mechanisms in migraine. | J Headache Pain | 2026 | 42260332 | PubTator, text mining | PubMed |
| Label-Free Fluorescent Detection of T4 PNK Using a DNA Mimic Green Fluorescent Protein-Based Turn-On Biosensor. | J Fluoresc | 2026 | 42209914 | PubTator, text mining | PubMed |
| Substrate selectivity of the human RNA m5C methyltransferase NSUN2. | Nature | 2026 | 42203868 | PubTator, text mining | PubMed |
| Microcephaly, seizures and developmental delay caused by two novel mutations in the PNKP gene: a case report. | Transl Pediatr | 2026 | 41982948 | PubTator, text mining | PubMed |
| Variations in DNA Repair Genes and Intratumoral Genetic Heterogeneity in Temozolomide-Resistant Glioblastoma. | Hum Mutat | 2026 | 41969610 | PubTator, text mining | PubMed |
1 to 10 of 2,557
See all 2,557 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/11284
GET https://conductscience.org/api/genes/v1/11284/patents?page=2