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Gene · 11284

PNKP: polynucleotide kinase 3'-phosphatase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PNKP: polynucleotide kinase 3'-phosphatase. Genes, record 11284. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11284

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Gene

Symbol
PNKP
HGNC
Name
polynucleotide kinase 3'-phosphatase
HGNC
NCBI Gene ID
11284
NCBI Gene
HGNC ID
HGNC:9154
HGNC
Ensembl
ENSG00000039650
NCBI Gene
Aliases
AOA4, CMT2B2, EIEE10, MCSZ, PNK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96T60Bifunctional polynucleotide phosphatase/kinase5212Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026509506 A2026-03-19101Q96T60Espacenet
EP 4650780 A22025-11-195500Q96T60Espacenet
JP 2025517970 A2025-06-125500Q96T60Espacenet
WO 2025080780 A12025-04-17101Q96T60Espacenet
EP 4464338 A22024-11-20296Q96T60Espacenet
JP 2024123008 A2024-09-107796Q96T60Espacenet
US 11680268 B22023-06-20296Q96T60Espacenet
JP 2023514149 A2023-04-05130Q96T60Espacenet
KR 1020220141829 A2022-10-20101Q96T60Espacenet
KR 1020220133109 A2022-10-049Q96T60Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,363

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePNKP papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines632025
P30CA008748Cancer Center Support Grant212025
RM1HG008935Center for dynamic RNA epitranscriptomes - Renewal122025
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs122025
P30CA016672Cancer Center Support Grant112025
R01ES012512Roles of Lig3 and XRCC1 Genes in Genome Stability92025
P30CA021765Cancer Center Support Grant (CCSG)82025
P30CA077598Cancer Center Support Grant72025
ZIABC006161DNA Topoisomerases as nuclear and mitochondrial targets of Anticancer Drugs72025
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN62025

1 to 10 of 2,363Source NIH's project files

See all 2,363 nih grants

Papers2,557

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structural insights into RNA phosphorylation by the RNase PNK module of the human rixosome complex.Nucleic Acids Res202642708412PubTator, text miningPubMed
Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer.Front Syst Biol202642630458PubTator, text miningPubMed
Colorimetric Detection and Intracellular Imaging of Polynucleotide Kinase by the Phosphorylation-Induced Assembly of DNA-Modified Gold Nanoparticles.Anal Chem202642432832PubTator, text miningPubMed
Double-Strand Gated Biosensor for Ultrasensitive T4 PNK Detection via λ-Exonuclease-Driven Background Suppression and Dimer G-Triplex Signal Amplification.ACS Sens202642396923PubTator, text miningPubMed
The MLLT3 YEATS domain binds histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking transcription and RNA signaling to regulate hematopoiesis.Cell Rep202642268713PubTator, text miningPubMed
Integrative multi-omics analysis identifies endocrine-disrupting chemical-related molecular mechanisms in migraine.J Headache Pain202642260332PubTator, text miningPubMed
Label-Free Fluorescent Detection of T4 PNK Using a DNA Mimic Green Fluorescent Protein-Based Turn-On Biosensor.J Fluoresc202642209914PubTator, text miningPubMed
Substrate selectivity of the human RNA m5C methyltransferase NSUN2.Nature202642203868PubTator, text miningPubMed
Microcephaly, seizures and developmental delay caused by two novel mutations in the PNKP gene: a case report.Transl Pediatr202641982948PubTator, text miningPubMed
Variations in DNA Repair Genes and Intratumoral Genetic Heterogeneity in Temozolomide-Resistant Glioblastoma.Hum Mutat202641969610PubTator, text miningPubMed

1 to 10 of 2,557

See all 2,557 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/11284

GET https://conductscience.org/api/genes/v1/11284/patents?page=2