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Gene · 11335

CBX3: chromobox 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CBX3: chromobox 3. Genes, record 11335. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/11335

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Gene

Symbol
CBX3
HGNC
Name
chromobox 3
HGNC
NCBI Gene ID
11335
NCBI Gene
HGNC ID
HGNC:1553
HGNC
Ensembl
ENSG00000122565
NCBI Gene
Aliases
HECH, HP1-GAMMA, HP1Hs-gamma, HP1gamma
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13185Chromobox protein homolog 31838Ensembl, GeneID, HGNC

Source UniProt

Patents55

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-196207Q13185Espacenet
EP 4641201 A22025-10-295972Q13185Espacenet
JP 2025517969 A2025-06-125972Q13185Espacenet
JP 2025517970 A2025-06-126207Q13185Espacenet
US 12285484 B22025-04-29288Q13185Espacenet
US 12285484 B22025-04-29291Q13185Espacenet
US 12285484 B22025-04-29292Q13185Espacenet
US 12285484 B22025-04-29293Q13185Espacenet
US 12285484 B22025-04-29294Q13185Espacenet
US 12285484 B22025-04-29295Q13185Espacenet

1 to 10 of 55

See all 55 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,401

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCBX3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant142025
P30CA016672Cancer Center Support Grant102025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology92025
ZIABC010309Nuclear Architecture and Disease82025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
P30CA016086Cancer Center Support Grant62025
P30CA010815Consolidated Basic Cancer Research Program52025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA086862Cancer Center Support Grant52025
R01AR045203D4Z4 Coding Transcripts and FSHD42025

1 to 10 of 1,401Source NIH's project files

See all 1,401 nih grants

Papers1,834

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Minimal CBX3-Derived UCOE Confers Long-Term Resistance to Transgene Silencing in Human iPSCs During Neuronal Differentiation.Int J Mol Sci202642794476PubTator, text miningPubMed
CBX3 aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation in vitro via repressing SESN2-mediated mitophagy in an H3K9me3-dependent manner.Mol Biol Rep202642776360PubTator, text miningPubMed
tRNA-derived small RNAs in vascular smooth muscle cell phenotypic switching and vascular remodelling.Mol Biol Rep202642658340PubTator, text miningPubMed
CTCF primes repressive chromatin for rapid BRCA1/BARD1 recruitment to drive homologous recombination repair of DNA double-strand breaks.Nucleic Acids Res202642475683PubTator, text miningPubMed
HP1γ promotes the progression of colorectal cancer through interaction with RBPJ of the Notch signaling pathway.Cell Biol Toxicol202642387182PubTator, text miningPubMed
Multilayered control of mRNA delivery to cell protrusions drives localized mini-cytoplasm establishment for stress-induced cell activation.Nat Commun202642365002PubTator, text miningPubMed
Manipulating CD38 ectoenzymatic activity revitalizes regulatory T cells via deacetylase Sirt-1 in immune thrombocytopenia.J Thromb Haemost202642362030PubTator, text miningPubMed
Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma.Front Cell Dev Biol202642326014PubTator, text miningPubMed
CBX3 promotes epithelial-mesenchymal transition in synovial sarcoma via the SHH signaling pathway.Am J Cancer Res202642004054PubTator, text miningPubMed
Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities.J Biomed Sci202641928257PubTator, text miningPubMed

1 to 10 of 1,834

See all 1,834 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/11335

GET https://conductscience.org/api/genes/v1/11335/patents?page=2