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Gene · 1136

CHRNA3: cholinergic receptor nicotinic alpha 3 subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHRNA3: cholinergic receptor nicotinic alpha 3 subunit. Genes, record 1136. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1136

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Gene

Symbol
CHRNA3
HGNC
Name
cholinergic receptor nicotinic alpha 3 subunit
HGNC
NCBI Gene ID
1136
NCBI Gene
HGNC ID
HGNC:1957
HGNC
Ensembl
ENSG00000080644
NCBI Gene
Aliases
BAIPRCK, LNCR2, NACHRA3, PAOD2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P32297Neuronal acetylcholine receptor subunit alpha-35055Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441228P32297Espacenet
JP 2026004568 A2026-01-1441231P32297Espacenet
EP 4650780 A22025-11-195019P32297Espacenet
EP 4641201 A22025-10-294601P32297Espacenet
JP 2025529142 A2025-09-04934P32297Espacenet
US 12371689 B22025-07-29934P32297Espacenet
JP 2025517969 A2025-06-124601P32297Espacenet
JP 2025517970 A2025-06-125019P32297Espacenet
EP 4551941 A22025-05-1436P32297Espacenet
JP 2025032204 A2025-03-1126361P32297Espacenet

1 to 10 of 39

See all 39 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASM-024CHEMBL3707249Neuronal acetylcholine receptor; alpha3/beta4 antagonistANTAGONISTChEMBL
LARAZOTIDECHEMBL2105646Neuronal acetylcholine receptor; alpha3/beta4 partial agonistPARTIAL AGONISTChEMBL
LARAZOTIDE ACETATECHEMBL2103815Neuronal acetylcholine receptor; alpha3/beta4 partial agonistPARTIAL AGONISTChEMBL
MECAMYLAMINECHEMBL267936Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
MECAMYLAMINE HYDROCHLORIDECHEMBL1237082Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
PENTOLINIUMCHEMBL1271Neuronal acetylcholine receptor; alpha3/beta4 antagonistANTAGONISTChEMBL
PENTOLINIUM TARTRATECHEMBL1318287Neuronal acetylcholine receptor; alpha3/beta4 antagonistANTAGONISTChEMBL
SIMPINICLINECHEMBL4594254Neuronal acetylcholine receptor; alpha3/beta4 agonistAGONISTChEMBL
TRIMETHAPHANCHEMBL1201329Neuronal acetylcholine receptor; alpha3/beta4 antagonistANTAGONISTChEMBL
TRIMETHAPHAN CAMSYLATECHEMBL1245Neuronal acetylcholine receptor; alpha3/beta4 antagonistANTAGONISTChEMBL

Trials29

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05747534LARAZOTIDEPHASE2ClinicalTrials.gov
NCT05022303LARAZOTIDE ACETATEPHASE2ClinicalTrials.gov
NCT03633461SIMPINICLINEPHASE22022-02-03ClinicalTrials.gov
NCT03452397SIMPINICLINEPHASE22021-12-14ClinicalTrials.gov
NCT03244488MECAMYLAMINEClinicalTrials.gov
NCT02726711TRIMETHAPHANPHASE1ClinicalTrials.gov
NCT02187094SIMPINICLINEPHASE1/PHASE2ClinicalTrials.gov
NCT01855230ASM-024PHASE2ClinicalTrials.gov
NCT01396213LARAZOTIDE ACETATEPHASE2ClinicalTrials.gov
NCT01190826ASM-024PHASE2ClinicalTrials.gov

1 to 10 of 29

See all 29 trials

NIH grants1,957

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHRNA3 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).282025
P30CA022453CANCER CENTER SUPPORT GRANT132025
P30CA016672Cancer Center Support Grant112025
R35CA197449Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer Research112025
P30CA023108Cancer Center Support Grant102025
P30CA076292Moffitt Cancer Center Support Grant102025
P50AA012870Center for the Translational Neuroscience of Alcoholism92025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal72025
U01CA164973Understanding Population Differences in Cancer: The MEC Study62025
P30DK063491Diabetes Research Center (DRC)52025

1 to 10 of 1,957Source NIH's project files

See all 1,957 nih grants

Papers1,369

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk.Nat Commun202642706231PubTator, text miningPubMed
CHRNA gene alterations in epilepsy: A systematic review of alpha subunit associations with ADSHE, SeLIE, and SeLECTS.Epilepsy Res202642607591PubTator, text miningPubMed
Comparative Study of Single-Cell and Bulk RNA Sequencing Data from Metastatic Bone Marrow Neuroblastoma Samples.Cells202642439616PubTator, text miningPubMed
E-cigarette aerosols induce the hydrolysis of lysosomal glycerophospholipids through PLA2G4A activation initiated by nicotine binding to CHRNA3/α3 nAChR in airway epithelial cells.Autophagy202642287088PubTator, text miningPubMed
Exploring the shared genetic architecture between periodontitis and cardiovascular disease.BDJ Open202641916952PubTator, text miningPubMed
An evaluation of age-varying genetic effects underlying body-mass index and blood pressure in the UK Biobank.PLoS Genet202641860901PubTator, text miningPubMed
Genetic Architecture of Comorbidity Between Chronic Obstructive Pulmonary Disease and Cardiovascular Diseases: Exploring Shared Mechanisms and Potential Therapeutic Targets.Int J Chron Obstruct Pulmon Dis202641859020PubTator, text miningPubMed
Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries.Nat Commun202641735279PubTator, text miningPubMed
Genome-wide Association Study Identifies IL1RL1 and KIAA1217 Associated With Asthma-Chronic Obstructive Pulmonary Disease Overlap in the All of Us Research Program.Allergy Asthma Immunol Res202641592539PubTator, text miningPubMed
Genetic risk factors for pneumonia differ by patient subgroup.EBioMedicine202641579494PubTator, text miningPubMed

1 to 10 of 1,369

See all 1,369 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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