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CHRNA4: cholinergic receptor nicotinic alpha 4 subunit

1 protein, 29 patents, 19 drugs, 642 trials, 3,498 NIH grants and 6,471 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCHRNA4HGNC
Namecholinergic receptor nicotinic alpha 4 subunitHGNC
NCBI Gene ID1137NCBI Gene
HGNC IDHGNC:1958HGNC
EnsemblENSG00000101204NCBI Gene
AliasesBFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P43681Neuronal acetylcholine receptor subunit alpha-462712Ensembl, GeneID, HGNCUniProt

Patents 29

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441233P43681Espacenet
EP 4650780 A22025-11-198751P43681Espacenet
EP 4641201 A22025-10-298945P43681Espacenet
JP 2025529142 A2025-09-04935P43681Espacenet
US 12371689 B22025-07-29935P43681Espacenet
JP 2025517969 A2025-06-128945P43681Espacenet
JP 2025517970 A2025-06-128751P43681Espacenet
EP 4551941 A22025-05-1437P43681Espacenet
US 11446398 B22022-09-2015050P43681Espacenet
US 11400116 B22022-08-02225P43681Espacenet

Drugs 19

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABT-560CHEMBL3707354Neuronal acetylcholine receptor; alpha4/beta2 modulatorMODULATORChEMBL
ALTINICLINECHEMBL111659Neuronal acetylcholine receptor; alpha4/beta2 agonistAGONISTChEMBL
AZD1446CHEMBL2179529Neuronal acetylcholine receptor; alpha4/beta2 agonistAGONISTChEMBL
CP-601927CHEMBL3341965Neuronal acetylcholine receptor; alpha4/beta2 partial agonistPARTIAL AGONISTChEMBL
CYTISINICLINECHEMBL497939Neuronal acetylcholine receptor; alpha4/beta2 partial agonistPARTIAL AGONISTChEMBL
DEXMECAMYLAMINECHEMBL2103881Neuronal acetylcholine receptor; alpha4/beta2 antagonistANTAGONISTChEMBL
DIANICLINECHEMBL187927Neuronal acetylcholine receptor; alpha4/beta2 partial agonistPARTIAL AGONISTChEMBL
ISPRONICLINECHEMBL188462Neuronal acetylcholine receptor; alpha4/beta2 partial agonistPARTIAL AGONISTChEMBL
NICOTINECHEMBL3Neuronal acetylcholine receptor; alpha4/beta2 agonistAGONISTChEMBL
NICOTINE POLACRILEXCHEMBL1201536Neuronal acetylcholine receptor; alpha4/beta2 agonistAGONISTChEMBL

Trials 642

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07596485VARENICLINEPHASE1/PHASE2ClinicalTrials.gov
NCT07487818NICOTINEPHASE2/PHASE3ClinicalTrials.gov
NCT07466875NICOTINEClinicalTrials.gov
NCT07171112VARENICLINEPHASE2ClinicalTrials.gov
NCT07148232NICOTINEPHASE4ClinicalTrials.gov
NCT07145866VARENICLINEPHASE4ClinicalTrials.gov
NCT07099638VARENICLINEPHASE2ClinicalTrials.gov
NCT07099638NICOTINEPHASE2ClinicalTrials.gov
NCT07089901NICOTINEPHASE4ClinicalTrials.gov
NCT07075575NICOTINEClinicalTrials.gov

NIH grants 3498

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01MH077681Cholinergic Contribution to Circuits Guiding Behavioral Responses to Stressors342,025NIH's project files
ZIAAG000295Immobilized Proteins In Drug Discovery202,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award192,025NIH's project files
ZIAES090089Modulation Of Neuronal Channels and Receptors in the Brain162,025NIH's project files
T32MH014276Research Training - Biological Sciences152,025NIH's project files
K12DA000167Clinician Scientist Training Program (CSTP)122,025NIH's project files
T32DA007237Neurobiology of Addiction Training Program122,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant102,025NIH's project files
P42ES010356Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation102,025NIH's project files
P60AA007611Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol102,025NIH's project files

Papers 6471

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42795812PubTator, text miningPubMed
42737834PubTator, text miningPubMed
42692134PubTator, text miningPubMed
42624846PubTator, text miningPubMed
42607591PubTator, text miningPubMed
42556725PubTator, text miningPubMed
42523149PubTator, text miningPubMed
42511673PubTator, text miningPubMed
42450170PubTator, text miningPubMed
42375743PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license