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Gene · 1138

CHRNA5: cholinergic receptor nicotinic alpha 5 subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHRNA5: cholinergic receptor nicotinic alpha 5 subunit. Genes, record 1138. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1138

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Gene

Symbol
CHRNA5
HGNC
Name
cholinergic receptor nicotinic alpha 5 subunit
HGNC
NCBI Gene ID
1138
NCBI Gene
HGNC ID
HGNC:1959
HGNC
Ensembl
ENSG00000169684
NCBI Gene
Aliases
LNCR2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30532Neuronal acetylcholine receptor subunit alpha-54680Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441235P30532Espacenet
EP 4650780 A22025-11-193949P30532Espacenet
EP 4640849 A22025-10-29512P30532Espacenet
EP 4641201 A22025-10-293526P30532Espacenet
JP 2025147176 A2025-10-062873P30532Espacenet
JP 2025529142 A2025-09-04936P30532Espacenet
JP 2025529142 A2025-09-045871P30532Espacenet
US 12371689 B22025-07-295871P30532Espacenet
US 12371689 B22025-07-29936P30532Espacenet
JP 2025519096 A2025-06-24512P30532Espacenet

1 to 10 of 37

See all 37 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
POZANICLINECHEMBL127071Nicotinic acetylcholine receptor alpha4/beta2/alpha5 partial agonistPARTIAL AGONIST

Source ChEMBL

Trials10

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00809510POZANICLINEPHASE2ClinicalTrials.gov
NCT00686933POZANICLINEPHASE2ClinicalTrials.gov
NCT00640419POZANICLINEPHASE2ClinicalTrials.gov
NCT00640185POZANICLINEPHASE2ClinicalTrials.gov
NCT00555204POZANICLINEPHASE2ClinicalTrials.gov
NCT00554385POZANICLINEPHASE2ClinicalTrials.gov
NCT00528697POZANICLINEPHASE2ClinicalTrials.gov
NCT00443391POZANICLINEPHASE2ClinicalTrials.gov
NCT00391729POZANICLINEPHASE2ClinicalTrials.gov
NCT00069849POZANICLINEPHASE2ClinicalTrials.gov

NIH grants2,059

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHRNA5 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).452025
R35CA197449Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer Research192025
P30CA076292Moffitt Cancer Center Support Grant182025
P30CA016672Cancer Center Support Grant172025
P30CA023108Cancer Center Support Grant162025
P30CA022453CANCER CENTER SUPPORT GRANT142025
P30CA091842Cancer Center Support Grant112025
T32HL007427SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES102025
P50AA012870Center for the Translational Neuroscience of Alcoholism82025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal72025

1 to 10 of 2,059Source NIH's project files

See all 2,059 nih grants

Papers1,383

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CHRNA gene alterations in epilepsy: A systematic review of alpha subunit associations with ADSHE, SeLIE, and SeLECTS.Epilepsy Res202642607591PubTator, text miningPubMed
The CHRNA5 rs16969968 variant is associated with MMP-9 expression and inflammatory signaling in COPD in a West Bengal population, India.Front Pharmacol202642422064PubTator, text miningPubMed
Dual E-Cigarette Users Show Nicotine Addiction Risk Alleles and Nuclear Abnormalities in Oral Epithelial Cells.Adv Respir Med202642345644PubTator, text miningPubMed
Association between CHRNA5 polymorphisms and Parkinson's disease in Northern Chinese Han population: a case-control study.Ann Hum Biol202642329050PubTator, text miningPubMed
Smoking exposure alters splicing of the nicotinic acetylcholine receptor subunit CHRNA5.Hum Genomics202642304190PubTator, text miningPubMed
TP53-META, a meta-analysis tool for comparative transcriptomics of TP53 dependency: examples from target silencing and liver fibrosis.BMC Bioinformatics202642277644PubTator, text miningPubMed
Exploring the shared genetic architecture between periodontitis and cardiovascular disease.BDJ Open202641916952PubTator, text miningPubMed
The clinical usefulness of knowing CHRNA5 polymorphism genotype: paving the way for personalized therapy.Tumori202641808243PubTator, text miningPubMed
Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries.Nat Commun202641735279PubTator, text miningPubMed
Genome-wide Association Study Identifies IL1RL1 and KIAA1217 Associated With Asthma-Chronic Obstructive Pulmonary Disease Overlap in the All of Us Research Program.Allergy Asthma Immunol Res202641592539PubTator, text miningPubMed

1 to 10 of 1,383

See all 1,383 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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