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CHRNA7: cholinergic receptor nicotinic alpha 7 subunit

1 protein, 61 patents, 18 drugs, 60 trials, 2,656 NIH grants and 5,552 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCHRNA7HGNC
Namecholinergic receptor nicotinic alpha 7 subunitHGNC
NCBI Gene ID1139NCBI Gene
HGNC IDHGNC:1960HGNC
EnsemblENSG00000175344NCBI Gene
AliasesCHRNA7-2, NACHRA7, a7nAChR, nAChR7NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P36544Neuronal acetylcholine receptor subunit alpha-750251Ensembl, GeneID, HGNCUniProt

Patents 61

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082870 A2026-05-194P36544Espacenet
JP 2026004568 A2026-01-1441238P36544Espacenet
EP 4650780 A22025-11-194231P36544Espacenet
JP 2025529142 A2025-09-04938P36544Espacenet
US 12371689 B22025-07-29938P36544Espacenet
JP 2025517970 A2025-06-124231P36544Espacenet
EP 4551941 A22025-05-1440P36544Espacenet
JP 2025508427 A2025-03-264P36544Espacenet
JP 2025508429 A2025-03-264P36544Espacenet
JP 2025504060 A2025-02-0625P36544Espacenet

Drugs 18

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABT-107CHEMBL2151570Neuronal acetylcholine receptor protein alpha-7 subunit agonistAGONISTChEMBL
ABT-126CHEMBL3545231Neuronal acetylcholine receptor protein alpha-7 subunit agonistAGONISTChEMBL
APN1125CHEMBL3545013Neuronal acetylcholine receptor protein alpha-7 subunit partial agonistPARTIAL AGONISTChEMBL
AQW051CHEMBL3545232Neuronal acetylcholine receptor protein alpha-7 subunit partial agonistPARTIAL AGONISTChEMBL
ASM-024CHEMBL3707249Neuronal acetylcholine receptor protein alpha-7 subunit modulatorMODULATORChEMBL
AVL-3288CHEMBL429317Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
AZD0328CHEMBL2151437Neuronal acetylcholine receptor protein alpha-7 subunit agonistAGONISTChEMBL
BNC-210CHEMBL4650452Neuronal acetylcholine receptor protein alpha-7 subunit negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
BRADANICLINECHEMBL1258006Neuronal acetylcholine receptor protein alpha-7 subunit agonistAGONISTChEMBL
ENCENICLINECHEMBL2151572Neuronal acetylcholine receptor protein alpha-7 subunit partial agonistPARTIAL AGONISTChEMBL

Trials 60

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06510504BNC-210PHASE3ClinicalTrials.gov
NCT05193409BNC-210PHASE22025-03-18ClinicalTrials.gov
NCT04951076BNC-210PHASE22025-02-06ClinicalTrials.gov
NCT04810104AZD0328PHASE2ClinicalTrials.gov
NCT03622216BRADANICLINEPHASE2ClinicalTrials.gov
NCT03548194BNC-210PHASE2ClinicalTrials.gov
NCT03281694AVL-3288PHASE1ClinicalTrials.gov
NCT02978599AVL-3288PHASE1ClinicalTrials.gov
NCT02933606BNC-210PHASE22023-02-27ClinicalTrials.gov
NCT02724917APN1125PHASE1/PHASE2ClinicalTrials.gov

NIH grants 2656

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAES090089Modulation Of Neuronal Channels and Receptors in the Brain272,025NIH's project files
T32DA007027Training in the pharmacology of abused drugs112,025NIH's project files
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)112,025NIH's project files
R01MH077681Cholinergic Contribution to Circuits Guiding Behavioral Responses to Stressors92,025NIH's project files
T32MH015442Development of Psychopathology, Psychobiology, & Behavior72,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award72,025NIH's project files
R01EB006841Multivariate methods for identifying multitask/multimodal brain imaging biomarkers62,025NIH's project files
R35GM118182Molecular basis of bioelectronic medicine62,025NIH's project files
P30MH075673JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN)52,025NIH's project files
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors52,025NIH's project files

Papers 5552

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822277PubTator, text miningPubMed
42790772PubTator, text miningPubMed
42785411PubTator, text miningPubMed
42782805PubTator, text miningPubMed
42761489PubTator, text miningPubMed
42760969PubTator, text miningPubMed
42744161PubTator, text miningPubMed
42737834PubTator, text miningPubMed
42718948PubTator, text miningPubMed
42716907PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license