Gene · 1141
CHRNB2: cholinergic receptor nicotinic beta 2 subunit
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CHRNB2: cholinergic receptor nicotinic beta 2 subunit. Genes, record 1141. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1141
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | 502 | 15 | Ensembl, GeneID, HGNC |
Source UniProt
Patents39
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 41248 | P17787 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8465 | P17787 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8628 | P17787 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 941 | P17787 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 941 | P17787 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8628 | P17787 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8465 | P17787 | Espacenet |
| JP 2025505245 A | 2025-02-21 | 6 | P17787 | Espacenet |
| JP 2024516160 A | 2024-04-12 | 3 | P17787 | Espacenet |
| KR 1020240001182 A | 2024-01-03 | 3 | P17787 | Espacenet |
1 to 10 of 39
See all 39 patentsDrugs20
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABT-560 | CHEMBL3707354 | Neuronal acetylcholine receptor; alpha4/beta2 modulator | MODULATOR | ChEMBL |
| ALTINICLINE | CHEMBL111659 | Neuronal acetylcholine receptor; alpha4/beta2 agonist | AGONIST | ChEMBL |
| AZD1446 | CHEMBL2179529 | Neuronal acetylcholine receptor; alpha4/beta2 agonist | AGONIST | ChEMBL |
| CP-601927 | CHEMBL3341965 | Neuronal acetylcholine receptor; alpha4/beta2 partial agonist | PARTIAL AGONIST | ChEMBL |
| CYTISINICLINE | CHEMBL497939 | Neuronal acetylcholine receptor; alpha4/beta2 partial agonist | PARTIAL AGONIST | ChEMBL |
| DEXMECAMYLAMINE | CHEMBL2103881 | Neuronal acetylcholine receptor; alpha4/beta2 antagonist | ANTAGONIST | ChEMBL |
| DIANICLINE | CHEMBL187927 | Neuronal acetylcholine receptor; alpha4/beta2 partial agonist | PARTIAL AGONIST | ChEMBL |
| ISPRONICLINE | CHEMBL188462 | Neuronal acetylcholine receptor; alpha4/beta2 partial agonist | PARTIAL AGONIST | ChEMBL |
| NICOTINE | CHEMBL3 | Neuronal acetylcholine receptor; alpha4/beta2 agonist | AGONIST | ChEMBL |
| NICOTINE POLACRILEX | CHEMBL1201536 | Neuronal acetylcholine receptor; alpha4/beta2 agonist | AGONIST | ChEMBL |
1 to 10 of 20
See all 20 drugsTrials642
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07596485 | VARENICLINE | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07487818 | NICOTINE | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07466875 | NICOTINE | ClinicalTrials.gov | ||
| NCT07171112 | VARENICLINE | PHASE2 | ClinicalTrials.gov | |
| NCT07148232 | NICOTINE | PHASE4 | ClinicalTrials.gov | |
| NCT07145866 | VARENICLINE | PHASE4 | ClinicalTrials.gov | |
| NCT07099638 | VARENICLINE | PHASE2 | ClinicalTrials.gov | |
| NCT07099638 | NICOTINE | PHASE2 | ClinicalTrials.gov | |
| NCT07089901 | NICOTINE | PHASE4 | ClinicalTrials.gov | |
| NCT07075575 | NICOTINE | ClinicalTrials.gov |
1 to 10 of 642
See all 642 trialsNIH grants819
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CHRNB2 papers | Newest fiscal year |
|---|---|---|---|
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 5 | 2025 |
| P01CA163227 | Androgen Receptor Action in Castration Resistant Prostate Cancer | 4 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 4 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 3 | 2025 |
| U01CA176726 | Life Course Cancer Epidemiology Cohort in Women | 3 | 2025 |
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 3 | 2025 |
| K01AA030083 | Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches | 2 | 2025 |
| P30AR072582 | Improving Health in Rheumatic Diseases (ImHeaRD) | 2 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 2 | 2025 |
1 to 10 of 819Source NIH's project files
See all 819 nih grantsPapers816
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Transcriptomic and experimental validation identify biomarkers and regulatory mechanisms associated with the aryl hydrocarbon receptor in nasopharyngeal carcinoma. | Transl Cancer Res | 2026 | 42591444 | PubTator, text mining | PubMed |
| Genetic risk for neurodevelopmental disorders as a potential factor affecting antipsychotic responsiveness in schizophrenia: a postmortem brain study. | Front Psychiatry | 2026 | 42125456 | PubTator, text mining | PubMed |
| Novel Genetic Insights into Lateral Temporal Lobe Epilepsy: Findings from Whole Exome Sequencing. | Noro Psikiyatr Ars | 2026 | 41777496 | PubTator, text mining | PubMed |
| Unraveling the mechanisms of slack channel mutations in epileptic disorders. | Acta Epileptol | 2026 | 41765992 | PubTator, text mining | PubMed |
| Molecular Profiling of Polish Pediatric Patients with Epilepsy: A Single-Center Diagnostic Experience Using Next-Generation Sequencing. | Genes (Basel) | 2026 | 41751517 | PubTator, text mining | PubMed |
| Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries. | Nat Commun | 2026 | 41735279 | PubTator, text mining | PubMed |
| Pediatric epilepsy: a dual diagnosis of SCMARCA2 -Nicolaides-Baraitser syndrome and CHRNB2 -nocturnal-frontal-lobe epilepsy. | Clin Dysmorphol | 2026 | 41198078 | PubTator, text mining | PubMed |
| Impact of secondhand smoke and e-cigarette aerosol on overweight or obesity in adolescents: a network pharmacology and toxicology study. | Inhal Toxicol | 2025 | 41085534 | PubTator, text mining | PubMed |
| Biallelic CRELD1 variants cause severe muscle weakness and infantile epilepsy. | Brain Commun | 2025 | 40980404 | PubTator, text mining | PubMed |
| Cholinergic Receptor Nicotinic Beta 2 Subunit Promotes the Peritoneal Disseminating Metastasis of Colorectal Cancer. | Cancers (Basel) | 2025 | 40805184 | PubTator, text mining | PubMed |
1 to 10 of 816
See all 816 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1141
GET https://conductscience.org/api/genes/v1/1141/patents?page=2