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Gene · 1141

CHRNB2: cholinergic receptor nicotinic beta 2 subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHRNB2: cholinergic receptor nicotinic beta 2 subunit. Genes, record 1141. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1141

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Gene

Symbol
CHRNB2
HGNC
Name
cholinergic receptor nicotinic beta 2 subunit
HGNC
NCBI Gene ID
1141
NCBI Gene
HGNC ID
HGNC:1962
HGNC
Ensembl
ENSG00000160716
NCBI Gene
Aliases
EFNL3, nAChRB2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17787Neuronal acetylcholine receptor subunit beta-250215Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441248P17787Espacenet
EP 4650780 A22025-11-198465P17787Espacenet
EP 4641201 A22025-10-298628P17787Espacenet
JP 2025529142 A2025-09-04941P17787Espacenet
US 12371689 B22025-07-29941P17787Espacenet
JP 2025517969 A2025-06-128628P17787Espacenet
JP 2025517970 A2025-06-128465P17787Espacenet
JP 2025505245 A2025-02-216P17787Espacenet
JP 2024516160 A2024-04-123P17787Espacenet
KR 1020240001182 A2024-01-033P17787Espacenet

1 to 10 of 39

See all 39 patents

Drugs20

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABT-560CHEMBL3707354Neuronal acetylcholine receptor; alpha4/beta2 modulatorMODULATORChEMBL
ALTINICLINECHEMBL111659Neuronal acetylcholine receptor; alpha4/beta2 agonistAGONISTChEMBL
AZD1446CHEMBL2179529Neuronal acetylcholine receptor; alpha4/beta2 agonistAGONISTChEMBL
CP-601927CHEMBL3341965Neuronal acetylcholine receptor; alpha4/beta2 partial agonistPARTIAL AGONISTChEMBL
CYTISINICLINECHEMBL497939Neuronal acetylcholine receptor; alpha4/beta2 partial agonistPARTIAL AGONISTChEMBL
DEXMECAMYLAMINECHEMBL2103881Neuronal acetylcholine receptor; alpha4/beta2 antagonistANTAGONISTChEMBL
DIANICLINECHEMBL187927Neuronal acetylcholine receptor; alpha4/beta2 partial agonistPARTIAL AGONISTChEMBL
ISPRONICLINECHEMBL188462Neuronal acetylcholine receptor; alpha4/beta2 partial agonistPARTIAL AGONISTChEMBL
NICOTINECHEMBL3Neuronal acetylcholine receptor; alpha4/beta2 agonistAGONISTChEMBL
NICOTINE POLACRILEXCHEMBL1201536Neuronal acetylcholine receptor; alpha4/beta2 agonistAGONISTChEMBL

1 to 10 of 20

See all 20 drugs

Trials642

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07596485VARENICLINEPHASE1/PHASE2ClinicalTrials.gov
NCT07487818NICOTINEPHASE2/PHASE3ClinicalTrials.gov
NCT07466875NICOTINEClinicalTrials.gov
NCT07171112VARENICLINEPHASE2ClinicalTrials.gov
NCT07148232NICOTINEPHASE4ClinicalTrials.gov
NCT07145866VARENICLINEPHASE4ClinicalTrials.gov
NCT07099638VARENICLINEPHASE2ClinicalTrials.gov
NCT07099638NICOTINEPHASE2ClinicalTrials.gov
NCT07089901NICOTINEPHASE4ClinicalTrials.gov
NCT07075575NICOTINEClinicalTrials.gov

1 to 10 of 642

See all 642 trials

NIH grants819

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHRNB2 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).52025
P01CA163227Androgen Receptor Action in Castration Resistant Prostate Cancer42025
P50CA097186The Pacific Northwest Prostate Cancer SPORE42025
P30CA015704Cancer Center Support Grant32025
P30CA016520Abramson Cancer Center Support Grant32025
U01CA176726Life Course Cancer Epidemiology Cohort in Women32025
ZIAAA000301Integrative genetics of behavior with high throughput technologies32025
K01AA030083Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches22025
P30AR072582Improving Health in Rheumatic Diseases (ImHeaRD)22025
P30CA006973Regional Oncology Research Center22025

1 to 10 of 819Source NIH's project files

See all 819 nih grants

Papers816

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Transcriptomic and experimental validation identify biomarkers and regulatory mechanisms associated with the aryl hydrocarbon receptor in nasopharyngeal carcinoma.Transl Cancer Res202642591444PubTator, text miningPubMed
Genetic risk for neurodevelopmental disorders as a potential factor affecting antipsychotic responsiveness in schizophrenia: a postmortem brain study.Front Psychiatry202642125456PubTator, text miningPubMed
Novel Genetic Insights into Lateral Temporal Lobe Epilepsy: Findings from Whole Exome Sequencing.Noro Psikiyatr Ars202641777496PubTator, text miningPubMed
Unraveling the mechanisms of slack channel mutations in epileptic disorders.Acta Epileptol202641765992PubTator, text miningPubMed
Molecular Profiling of Polish Pediatric Patients with Epilepsy: A Single-Center Diagnostic Experience Using Next-Generation Sequencing.Genes (Basel)202641751517PubTator, text miningPubMed
Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries.Nat Commun202641735279PubTator, text miningPubMed
Pediatric epilepsy: a dual diagnosis of SCMARCA2 -Nicolaides-Baraitser syndrome and CHRNB2 -nocturnal-frontal-lobe epilepsy.Clin Dysmorphol202641198078PubTator, text miningPubMed
Impact of secondhand smoke and e-cigarette aerosol on overweight or obesity in adolescents: a network pharmacology and toxicology study.Inhal Toxicol202541085534PubTator, text miningPubMed
Biallelic CRELD1 variants cause severe muscle weakness and infantile epilepsy.Brain Commun202540980404PubTator, text miningPubMed
Cholinergic Receptor Nicotinic Beta 2 Subunit Promotes the Peritoneal Disseminating Metastasis of Colorectal Cancer.Cancers (Basel)202540805184PubTator, text miningPubMed

1 to 10 of 816

See all 816 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1141

GET https://conductscience.org/api/genes/v1/1141/patents?page=2