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Gene · 1143

CHRNB4: cholinergic receptor nicotinic beta 4 subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CHRNB4: cholinergic receptor nicotinic beta 4 subunit. Genes, record 1143. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1143

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Gene

Symbol
CHRNB4
HGNC
Name
cholinergic receptor nicotinic beta 4 subunit
HGNC
NCBI Gene ID
1143
NCBI Gene
HGNC ID
HGNC:1964
HGNC
Ensembl
ENSG00000117971
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30926Neuronal acetylcholine receptor subunit beta-44984Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441250P30926Espacenet
EP 4650780 A22025-11-191951P30926Espacenet
EP 4641201 A22025-10-291535P30926Espacenet
JP 2025529142 A2025-09-04943P30926Espacenet
US 12371689 B22025-07-29943P30926Espacenet
JP 2025517969 A2025-06-121535P30926Espacenet
JP 2025517970 A2025-06-121951P30926Espacenet
EP 4551941 A22025-05-1446P30926Espacenet
JP 2024516159 A2024-04-122P30926Espacenet
KR 1020240000561 A2024-01-022P30926Espacenet

1 to 10 of 31

See all 31 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASM-024CHEMBL3707249Neuronal acetylcholine receptor; alpha3/beta4 antagonistANTAGONISTChEMBL
LARAZOTIDECHEMBL2105646Neuronal acetylcholine receptor; alpha3/beta4 partial agonistPARTIAL AGONISTChEMBL
LARAZOTIDE ACETATECHEMBL2103815Neuronal acetylcholine receptor; alpha3/beta4 partial agonistPARTIAL AGONISTChEMBL
MECAMYLAMINECHEMBL267936Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
MECAMYLAMINE HYDROCHLORIDECHEMBL1237082Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
PENTOLINIUMCHEMBL1271Neuronal acetylcholine receptor; alpha3/beta4 antagonistANTAGONISTChEMBL
PENTOLINIUM TARTRATECHEMBL1318287Neuronal acetylcholine receptor; alpha3/beta4 antagonistANTAGONISTChEMBL
SIMPINICLINECHEMBL4594254Neuronal acetylcholine receptor; alpha3/beta4 agonistAGONISTChEMBL
TRIMETHAPHANCHEMBL1201329Neuronal acetylcholine receptor; alpha3/beta4 antagonistANTAGONISTChEMBL
TRIMETHAPHAN CAMSYLATECHEMBL1245Neuronal acetylcholine receptor; alpha3/beta4 antagonistANTAGONISTChEMBL

Trials29

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05747534LARAZOTIDEPHASE2ClinicalTrials.gov
NCT05022303LARAZOTIDE ACETATEPHASE2ClinicalTrials.gov
NCT03633461SIMPINICLINEPHASE22022-02-03ClinicalTrials.gov
NCT03452397SIMPINICLINEPHASE22021-12-14ClinicalTrials.gov
NCT03244488MECAMYLAMINEClinicalTrials.gov
NCT02726711TRIMETHAPHANPHASE1ClinicalTrials.gov
NCT02187094SIMPINICLINEPHASE1/PHASE2ClinicalTrials.gov
NCT01855230ASM-024PHASE2ClinicalTrials.gov
NCT01396213LARAZOTIDE ACETATEPHASE2ClinicalTrials.gov
NCT01190826ASM-024PHASE2ClinicalTrials.gov

1 to 10 of 29

See all 29 trials

NIH grants1,451

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCHRNB4 papersNewest fiscal year
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).232025
P30CA016672Cancer Center Support Grant102025
P30CA023108Cancer Center Support Grant92025
R35CA197449Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer Research92025
P30CA076292Moffitt Cancer Center Support Grant82025
P30CA022453CANCER CENTER SUPPORT GRANT72025
P50AA012870Center for the Translational Neuroscience of Alcoholism72025
U01CA164973Understanding Population Differences in Cancer: The MEC Study52025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)42025
P30CA091842Cancer Center Support Grant42025

1 to 10 of 1,451Source NIH's project files

See all 1,451 nih grants

Papers807

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated multi-omics analysis reveals gut microbiota-associated placental metabolic and transcriptomic alterations in placenta previa.mSystems202642454935PubTator, text miningPubMed
Epidemiological Trends and Germline Variant Analysis of Young-Onset Bladder Cancer.Clin Genitourin Cancer202642236361PubTator, text miningPubMed
CHRNB4-Mediated Neuroactive Signaling Rewiring Drives Adaptive Resistance to BCL-2 Inhibition in Acute Myeloid Leukemia.Cancers (Basel)202642073514PubTator, text miningPubMed
Exploring the shared genetic architecture between periodontitis and cardiovascular disease.BDJ Open202641916952PubTator, text miningPubMed
Molecular signatures and causal factors underlying latent cytomegalovirus infection among people living with HIV (PLHIV).Nat Commun202641881997PubTator, text miningPubMed
Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries.Nat Commun202641735279PubTator, text miningPubMed
Rewired Neuroactive Ligand-Receptor Signaling Confers Adaptive Resistance to BCL-2 Inhibition in AML.Res Sq202641646400PubTator, text miningPubMed
Genetic risk factors for pneumonia differ by patient subgroup.EBioMedicine202641579494PubTator, text miningPubMed
Association of SNPs in nAChRs genes, areca nut chewing and smoking, and their interaction with lung cancer in Hainan, China: a case control study.BMC Cancer202540197297PubTator, text miningPubMed
fastGxE: Powering genome-wide detection of genotype-environment interactions in biobank studies.Res Sq202540166017PubTator, text miningPubMed

1 to 10 of 807

See all 807 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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