ConductScience.org, home

Library / Genes

NLRP3: NLR family pyrin domain containing 3

1 protein, 65 patents, 0 drugs, 0 trials, 10,832 NIH grants and 40,977 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNLRP3HGNC
NameNLR family pyrin domain containing 3HGNC
NCBI Gene ID114548NCBI Gene
HGNC IDHGNC:16400HGNC
EnsemblENSG00000162711NCBI Gene
AliasesAGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCAS1, FCU, KEFH, MWS, NALP3, PYPAF1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q96P20NACHT, LRR and PYD domains-containing protein 31,03624GeneID, HGNCUniProt

Patents 65

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026509587 A2026-03-191Q96P20Espacenet
EP 4685142 A12026-01-281Q96P20Espacenet
JP 2026004568 A2026-01-1455823Q96P20Espacenet
JP 2026004568 A2026-01-1455828Q96P20Espacenet
US 12509459 B22025-12-301Q96P20Espacenet
WO 2025262233 A12025-12-261Q96P20Espacenet
KR 1020250162889 A2025-11-191Q96P20Espacenet
EP 4641201 A22025-10-296033Q96P20Espacenet
WO 2025207644 A12025-10-021Q96P20Espacenet
EP 4572801 A12025-06-252Q96P20Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 10832

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation702,025NIH's project files
R01AI124346Innate immune signaling and stress response642,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award472,025NIH's project files
P30CA008748Cancer Center Support Grant342,025NIH's project files
R01AI015614Pathogenesis of Fever in Man332,025NIH's project files
R35CA253095Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer302,025NIH's project files
ZIDAR041180Clinical Support Services for the NIAMS Intramural Research Program302,025NIH's project files
R01AI124491NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing252,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology242,025NIH's project files
ZIAHG200372Genetics, Pathophysiology, and Treatment of Autoinflammatory and Autoimmune Diseases232,025NIH's project files

Papers 40977

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825037PubTator, text miningPubMed
42824924PubTator, text miningPubMed
42824866PubTator, text miningPubMed
42824268PubTator, text miningPubMed
42824032PubTator, text miningPubMed
42823960PubTator, text miningPubMed
42822254PubTator, text miningPubMed
42822210PubTator, text miningPubMed
42821796PubTator, text miningPubMed
42821485PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license