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Gene · 114609

TIRAP: TIR domain containing adaptor protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TIRAP: TIR domain containing adaptor protein. Genes, record 114609. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/114609

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Gene

Symbol
TIRAP
HGNC
Name
TIR domain containing adaptor protein
HGNC
NCBI Gene ID
114609
NCBI Gene
HGNC ID
HGNC:17192
HGNC
Ensembl
ENSG00000150455
NCBI Gene
Aliases
BACTS1, Mal, MyD88-2, wyatt
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P58753Toll/interleukin-1 receptor domain-containing adapter protein22111Ensembl, GeneID, HGNC

Source UniProt

Patents53

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4640849 A22025-10-291672P58753Espacenet
EP 4641201 A22025-10-2911347P58753Espacenet
JP 2025519096 A2025-06-241672P58753Espacenet
JP 2025517969 A2025-06-1211347P58753Espacenet
JP 2024123008 A2024-09-108732P58753Espacenet
JP 2024123008 A2024-09-108733P58753Espacenet
JP 2024123008 A2024-09-108734P58753Espacenet
US 11944645 B22024-04-0229P58753Espacenet
US 11446398 B22022-09-2089145P58753Espacenet
US 11446398 B22022-09-2089146P58753Espacenet

1 to 10 of 53

See all 53 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,472

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTIRAP papersNewest fiscal year
P30DK034854Integrated Epithelial and Muscosal Biology202025
P60AA011605Molecular and Circuit Pathogenesis of Alcohol Use Disorders72025
ZIAES102605The Role of Hyaluronan And Inter-Alpha-Trypsin Inhibitor in Tissue Injury52025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital42025
P30AG028740University of Florida Older Americans Independence Center (OAIC)32025
P30CA016672Cancer Center Support Grant32025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis32025
T32GM008721Molecular Biology in Burns and Trauma32025
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged32025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success32025

1 to 10 of 1,472Source NIH's project files

See all 1,472 nih grants

Papers2,254

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TRAM promotes Toll-like-receptor-free myddosome signal transduction.Nature202642778610PubTator, text miningPubMed
Nuclear localization of Toll/interleukin-1 receptor domain-containing adaptor protein reveals a previously unrecognized role in hepatic stellate cell activation.Front Immunol202642698655PubTator, text miningPubMed
Toll/IL-1 receptor domain-containing adaptor protein plays a crucial role in macrophage-mediated hepatic stellate cell activation in alcoholic liver disease.Front Cell Dev Biol202642614271PubTator, text miningPubMed
Roles of TIR domain-containing adaptor protein in tumor: Inflammation and immune regulation via toll-like receptor signaling.J Int Med Res202642606330PubTator, text miningPubMed
Genetic susceptibility to aseptic loosening following total hip and knee arthroplasty: a systematic review of candidate-gene and genome-wide association studies.Br Med Bull202642574754PubTator, text miningPubMed
MyD88-Family Adaptors: Compartmentalised Signalling and Non-Immune Functions.Immunology202642552630PubTator, text miningPubMed
Integrative Bioinformatics Prioritizes the TLR4 Axis and Candidate Non-Starch Polysaccharides in Hyperuricemia-Associated Inflammation.Biology (Basel)202642510697PubTator, text miningPubMed
The Dual Role of TLR2 in Breast Cancer: Implications for Therapeutic Targeting.Immunol Invest202642446204PubTator, text miningPubMed
A pyroptosis-related molecular signature stratifies prognosis and highlights GSDMB-mediated malignancy in intrahepatic cholangiocarcinoma.Biol Direct202642098854PubTator, text miningPubMed
Adaptor protein supersaturation drives innate immune signaling and cell fate.Elife202641873950PubTator, text miningPubMed

1 to 10 of 2,254

See all 2,254 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/114609

GET https://conductscience.org/api/genes/v1/114609/patents?page=2