Gene · 114609
TIRAP: TIR domain containing adaptor protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TIRAP: TIR domain containing adaptor protein. Genes, record 114609. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/114609
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P58753 | Toll/interleukin-1 receptor domain-containing adapter protein | 221 | 11 | Ensembl, GeneID, HGNC |
Source UniProt
Patents53
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4640849 A2 | 2025-10-29 | 1672 | P58753 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 11347 | P58753 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1672 | P58753 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 11347 | P58753 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8732 | P58753 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8733 | P58753 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8734 | P58753 | Espacenet |
| US 11944645 B2 | 2024-04-02 | 29 | P58753 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 89145 | P58753 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 89146 | P58753 | Espacenet |
1 to 10 of 53
See all 53 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,472
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TIRAP papers | Newest fiscal year |
|---|---|---|---|
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 20 | 2025 |
| P60AA011605 | Molecular and Circuit Pathogenesis of Alcohol Use Disorders | 7 | 2025 |
| ZIAES102605 | The Role of Hyaluronan And Inter-Alpha-Trypsin Inhibitor in Tissue Injury | 5 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 4 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| R01AI127564 | Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis | 3 | 2025 |
| T32GM008721 | Molecular Biology in Burns and Trauma | 3 | 2025 |
| U19AI057266 | Vaccine and Infection Induced Immunity in the Young and Aged | 3 | 2025 |
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 3 | 2025 |
1 to 10 of 1,472Source NIH's project files
See all 1,472 nih grantsPapers2,254
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| TRAM promotes Toll-like-receptor-free myddosome signal transduction. | Nature | 2026 | 42778610 | PubTator, text mining | PubMed |
| Nuclear localization of Toll/interleukin-1 receptor domain-containing adaptor protein reveals a previously unrecognized role in hepatic stellate cell activation. | Front Immunol | 2026 | 42698655 | PubTator, text mining | PubMed |
| Toll/IL-1 receptor domain-containing adaptor protein plays a crucial role in macrophage-mediated hepatic stellate cell activation in alcoholic liver disease. | Front Cell Dev Biol | 2026 | 42614271 | PubTator, text mining | PubMed |
| Roles of TIR domain-containing adaptor protein in tumor: Inflammation and immune regulation via toll-like receptor signaling. | J Int Med Res | 2026 | 42606330 | PubTator, text mining | PubMed |
| Genetic susceptibility to aseptic loosening following total hip and knee arthroplasty: a systematic review of candidate-gene and genome-wide association studies. | Br Med Bull | 2026 | 42574754 | PubTator, text mining | PubMed |
| MyD88-Family Adaptors: Compartmentalised Signalling and Non-Immune Functions. | Immunology | 2026 | 42552630 | PubTator, text mining | PubMed |
| Integrative Bioinformatics Prioritizes the TLR4 Axis and Candidate Non-Starch Polysaccharides in Hyperuricemia-Associated Inflammation. | Biology (Basel) | 2026 | 42510697 | PubTator, text mining | PubMed |
| The Dual Role of TLR2 in Breast Cancer: Implications for Therapeutic Targeting. | Immunol Invest | 2026 | 42446204 | PubTator, text mining | PubMed |
| A pyroptosis-related molecular signature stratifies prognosis and highlights GSDMB-mediated malignancy in intrahepatic cholangiocarcinoma. | Biol Direct | 2026 | 42098854 | PubTator, text mining | PubMed |
| Adaptor protein supersaturation drives innate immune signaling and cell fate. | Elife | 2026 | 41873950 | PubTator, text mining | PubMed |
1 to 10 of 2,254
See all 2,254 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/114609
GET https://conductscience.org/api/genes/v1/114609/patents?page=2