ConductScience.org, home

Library / Genes

CHUK: component of inhibitor of nuclear factor kappa B kinase complex

1 protein, 71 patents, 0 drugs, 0 trials, 4,587 NIH grants and 8,370 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCHUKHGNC
Namecomponent of inhibitor of nuclear factor kappa B kinase complexHGNC
NCBI Gene ID1147NCBI Gene
HGNC IDHGNC:1974HGNC
EnsemblENSG00000213341NCBI Gene
AliasesBPS2, IKBKA, IKK-1, IKK-alpha, IKK1, IKKA, IkBKA, NFKBIKA, TCF16NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O15111Inhibitor of nuclear factor kappa-B kinase subunit alpha7455Ensembl, GeneID, HGNCUniProt

Patents 71

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0383O15111Espacenet
EP 4650780 A22025-11-198770O15111Espacenet
EP 4641201 A22025-10-298970O15111Espacenet
JP 2025524002 A2025-07-2527O15111Espacenet
JP 2025517969 A2025-06-128970O15111Espacenet
JP 2025517970 A2025-06-128770O15111Espacenet
KR 1020250039465 A2025-03-2027O15111Espacenet
US 12133879 B22024-11-0583O15111Espacenet
JP 2024123008 A2024-09-105671O15111Espacenet
JP 2024023699 A2024-02-2127O15111Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 4587

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant692,025NIH's project files
P30CA068485Cancer Center Support Grant142,025NIH's project files
P01CA125066Discovery of Anticancer Agents of Diverse Natural Origin132,025NIH's project files
ZIABC011212Functions of IKK alpha in Skin Homeostasis and Skin Tumorigenesis122,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant112,025NIH's project files
R37AI043477NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation112,025NIH's project files
P30CA016058Cancer Center Support Grant92,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center92,025NIH's project files
P30ES001247Environmental Agents as Modulators of Disease Processes92,025NIH's project files
P30CA013330Cancer Center Support Grant82,025NIH's project files

Papers 8370

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42793128PubTator, text miningPubMed
42724825PubTator, text miningPubMed
42721161PubTator, text miningPubMed
42708602PubTator, text miningPubMed
42693651PubTator, text miningPubMed
42673838PubTator, text miningPubMed
42640212PubTator, text miningPubMed
42521833PubTator, text miningPubMed
42501125PubTator, text miningPubMed
42498057PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license