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CGAS: cyclic GMP-AMP synthase

1 protein, 46 patents, 0 drugs, 0 trials, 5,005 NIH grants and 11,650 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCGASHGNC
Namecyclic GMP-AMP synthaseHGNC
NCBI Gene ID115004NCBI Gene
HGNC IDHGNC:21367HGNC
EnsemblENSG00000164430NCBI Gene
AliasesC6orf150, D4, MB21D1, h-cGASNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q8N884Cyclic GMP-AMP synthase522107Ensembl, GeneID, HGNCUniProt

Patents 46

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026148146 A12026-07-0937Q8N884Espacenet
JP 2026004568 A2026-01-1452184Q8N884Espacenet
EP 4641201 A22025-10-298955Q8N884Espacenet
EP 4641202 A22025-10-295487Q8N884Espacenet
JP 2025517969 A2025-06-128955Q8N884Espacenet
JP 2025516636 A2025-05-3010Q8N884Espacenet
JP 2025516637 A2025-05-3010Q8N884Espacenet
KR 1020250023373 A2025-02-1810Q8N884Espacenet
KR 1020250022050 A2025-02-1410Q8N884Espacenet
KR 1020250017231 A2025-02-045487Q8N884Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5005

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant852,025NIH's project files
P30CA016672Cancer Center Support Grant452,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology192,025NIH's project files
P01CA019014Viral Oncogenesis, Latency, and Replication172,025NIH's project files
P30CA016086Cancer Center Support Grant142,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program132,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support132,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant132,025NIH's project files
R01AI124346Innate immune signaling and stress response132,025NIH's project files
R01DE026728Restoring the Immunogenicity of Head and Neck Cancer132,025NIH's project files

Papers 11650

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826719PubTator, text miningPubMed
42825382PubTator, text miningPubMed
42823831PubTator, text miningPubMed
42821672PubTator, text miningPubMed
42820930PubTator, text miningPubMed
42820221PubTator, text miningPubMed
42817599PubTator, text miningPubMed
42816669PubTator, text miningPubMed
42816648PubTator, text miningPubMed
42816544PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license