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Gene · 1152

CKB: creatine kinase B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CKB: creatine kinase B. Genes, record 1152. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1152

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Gene

Symbol
CKB
HGNC
Name
creatine kinase B
HGNC
NCBI Gene ID
1152
NCBI Gene
HGNC ID
HGNC:1991
HGNC
Ensembl
ENSG00000166165
NCBI Gene
Aliases
B-CK, BCK, CKBB, CPK-B, HEL-211, HEL-S-29
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P12277Creatine kinase B-type3816Ensembl, GeneID, HGNC

Source UniProt

Patents77

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442334P12277Espacenet
EP 4650780 A22025-11-193922P12277Espacenet
JP 2025517970 A2025-06-123922P12277Espacenet
JP 2025013795 A2025-01-2826P12277Espacenet
JP 2024528705 A2024-07-301P12277Espacenet
EP 4373582 A12024-05-291P12277Espacenet
US 11965885 B22024-04-2329P12277Espacenet
US 11860162 B22024-01-021479P12277Espacenet
JP 2023510658 A2023-03-154P12277Espacenet
US 11446398 B22022-09-2020147P12277Espacenet

1 to 10 of 77

See all 77 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,266

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCKB papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30AI027763UCSF-Bay Area Center for AIDS Research42025
P30CA016086Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30CA021765Cancer Center Support Grant (CCSG)42025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control42025
P30CA047904Cancer Center Support Grant32025
P30CA118100University of New Mexico Cancer Center Support Grant32025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
P20GM103427Nebraska Research Network in Functional Genomics22025

1 to 10 of 1,266Source NIH's project files

See all 1,266 nih grants

Papers2,289

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
GSLR Drives Lung Adenocarcinoma as a Critical Regulator of Energy Homeostasis Through Creatine Kinase B Activation.Adv Sci (Weinh)202642801620PubTator, text miningPubMed
Candidate proteomic indirect-effect signals linking dementia to probable muscle-bone fragility: a UK Biobank cohort study.Front Med (Lausanne)202642780496PubTator, text miningPubMed
Integrative plasma proteomic network analysis identifies physical activity-associated protein modules potentially mediating type 2 diabetes risk.Cardiovasc Diabetol202642778924PubTator, text miningPubMed
An AI-Driven Chemogenomics Knowledgebase for Human-Transmissible Pathogens: A Platform for Antimicrobial Drug Discovery.J Chem Inf Model202642743006PubTator, text miningPubMed
A self-sustaining hypoxia inducible factor-1α-creatine kinase B feedforward circuit drives macrophage-mediated kidney fibrosis.Kidney Int202642628836PubTator, text miningPubMed
Derivation and validation of a pre-bronchodilator FEV1/FVC threshold for point-of-care diagnosis triage of COPD in primary care: a multi-cohort population-based study.Lancet Reg Health West Pac202642621354PubTator, text miningPubMed
Dimer opening enables brain-type creatine kinase to sense membrane curvature.bioRxiv202642620321PubTator, text miningPubMed
How Often are druggable mutations detectable in Metastatic Castration Resistant Prostate Cancer?Urol Int202642594033PubTator, text miningPubMed
Kinetic and inhibitory profiling of serum MMP-9 in acute spinal cord injury: neurochemical links to injury severity and neuroinflammation.Acta Neurol Belg202642570066PubTator, text miningPubMed
Complement System-Related Genes in Diabetic Nephropathy: Screening for Potential Targets of the Mechanism.J Diabetes Res202642402786PubTator, text miningPubMed

1 to 10 of 2,289

See all 2,289 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1152

GET https://conductscience.org/api/genes/v1/1152/patents?page=2