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Gene · 1154

CISH: cytokine inducible SH2 containing protein

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. CISH: cytokine inducible SH2 containing protein. Genes, record 1154. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/1154

On this page

Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
CISH
HGNC
Name
cytokine inducible SH2 containing protein
HGNC
NCBI Gene ID
1154
NCBI Gene
HGNC ID
HGNC:1984
HGNC
Ensembl
ENSG00000114737
NCBI Gene
Aliases
BACTS2, CIS, CIS-1, G18, SOCS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NSE2Cytokine-inducible SH2-containing protein2580Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442967Q9NSE2Espacenet
WO 2025163107 A12025-08-074Q9NSE2Espacenet
US 12016902 B22024-06-2510Q9NSE2Espacenet
JP 2024521566 A2024-06-0336Q9NSE2Espacenet
KR 1020240010717 A2024-01-2429Q9NSE2Espacenet
EP 4253412 A22023-10-046Q9NSE2Espacenet
US 11492404 B22022-11-086Q9NSE2Espacenet
US 11446398 B22022-09-2022181Q9NSE2Espacenet
US 11339220 B22022-05-246Q9NSE2Espacenet
JP 2022524081 A2022-04-27125152Q9NSE2Espacenet

1 to 10 of 46

See all 46 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,852

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P30CA008748Cancer Center Support Grant142025
R01AR046713Cytokine regulation of RA synoviocyte phenotype102025
R01AI044938Inhibition of STAT3 and inflammatory cytokine production92025
R01AR050401Cytokine Balance in Rheumatoid Arthritis82025
P30DK020572Michigan Diabetes Research Center (MDRC)72025
R01AI046712Activation of Macrophages in Human Autoimmune Diseases72025
UL1TR001863Yale Clinical and Translational Science Award72025
P30CA006973Regional Oncology Research Center62025
P30CA016058Cancer Center Support Grant62025

1 to 10 of 2,852Source NIH's project files

See all 2,852 nih grants

Papers4,557

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42809484PubTator, text miningPubMed
42780873PubTator, text miningPubMed
42771543PubTator, text miningPubMed
42756106PubTator, text miningPubMed
42745343PubTator, text miningPubMed
42725106PubTator, text miningPubMed
42682451PubTator, text miningPubMed
42570353PubTator, text miningPubMed
42470099PubTator, text miningPubMed
42458565PubTator, text miningPubMed

1 to 10 of 4,557

See all 4,557 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1154

GET https://conductscience.org/api/genes/v1/1154/patents?page=2