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Gene · 116

ADCYAP1: adenylate cyclase activating polypeptide 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADCYAP1: adenylate cyclase activating polypeptide 1. Genes, record 116. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/116

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Gene

Symbol
ADCYAP1
HGNC
Name
adenylate cyclase activating polypeptide 1
HGNC
NCBI Gene ID
116
NCBI Gene
HGNC ID
HGNC:241
HGNC
Ensembl
ENSG00000141433
NCBI Gene
Aliases
PACAP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P18509Pituitary adenylate cyclase-activating polypeptide17612Ensembl, GeneID, HGNC

Source UniProt

Patents59

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436707P18509Espacenet
JP 2026004568 A2026-01-1436708P18509Espacenet
JP 2026004568 A2026-01-1436710P18509Espacenet
EP 4650780 A22025-11-1913719P18509Espacenet
JP 2025147176 A2025-10-06403P18509Espacenet
JP 2025147176 A2025-10-06404P18509Espacenet
JP 2025529142 A2025-09-045406P18509Espacenet
US 12371689 B22025-07-295406P18509Espacenet
JP 2025517970 A2025-06-1213719P18509Espacenet
JP 2025062604 A2025-04-142836P18509Espacenet

1 to 10 of 59

See all 59 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,702

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADCYAP1 papersNewest fiscal year
ZIAMH002386Chemical Coding of Neurotransmission252025
ZIADK053101Cellular Basis Of Action Of Gastrointestinal Peptides/Growth factors142025
R01MH108665Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala Pathways102025
ZIADK053100Characterization And Pharmacology Of Receptors For Gastrointestinal Peptides102025
P30DA018310Neurometabolomics and Neuroproteomics Center on Cell-Cell Signaling62025
P30CA016042Cancer Center Support Grant52025
P51OD011132Emory National Primate Research Center52025
UL1TR001863Yale Clinical and Translational Science Award52025
ZIAHD000195Intracellular Signaling In Endocrine Cells52025
R01NS122534Pre and post-synaptic pathways underlying the stress response in the adrenal medulla42025

1 to 10 of 1,702Source NIH's project files

See all 1,702 nih grants

Papers3,279

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
[Advances in innate immune-mediated neuroinflammatory mechanisms of migraine].Zhejiang Da Xue Xue Bao Yi Xue Ban202642811262PubTator, text miningPubMed
Novel targets in headache: A narrative review.Headache202642806606PubTator, text miningPubMed
Emerging pharmacological targets in migraine therapy: CGRP and beyond.Front Pharmacol202642781272PubTator, text miningPubMed
Glyphosate alters the neurochemical phenotype of enteric neurons and modulates cytokine levels in the porcine ileum.Toxicol Lett202642767439PubTator, text miningPubMed
Substance P and PACAP activate dural mast cells through MRGPRX2, not NK1R or PAC1/VPAC receptors.Cephalalgia202642627518PubTator, text miningPubMed
Pituitary adenylate cyclase-activating polypeptide and mitochondrial homeostasis in neuronal injury: mechanisms and translational prospects.Front Immunol202642614376PubTator, text miningPubMed
Blood levels of PACAP in migraine: A systematic review.Cephalalgia202642578875PubTator, text miningPubMed
[Pituitary adenylate-cyclase activating polypeptide (PACAP)-targeting treatment as a potential migraine prophylactic therapy].Ideggyogy Sz202642554332PubTator, text miningPubMed
The role of Kynurenine-Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) axis in migraine pathophysiology and therapy.Ideggyogy Sz202642554331PubTator, text miningPubMed
Phenotype-guided Management of Post-traumatic Headache: An Update on Pathophysiology and Treatment.Curr Pain Headache Rep202642517979PubTator, text miningPubMed

1 to 10 of 3,279

See all 3,279 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/116

GET https://conductscience.org/api/genes/v1/116/patents?page=2