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Gene · 116085

SLC22A12: solute carrier family 22 member 12

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC22A12: solute carrier family 22 member 12. Genes, record 116085. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/116085

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Gene

Symbol
SLC22A12
HGNC
Name
solute carrier family 22 member 12
HGNC
NCBI Gene ID
116085
NCBI Gene
HGNC ID
HGNC:17989
HGNC
Ensembl
ENSG00000197891
NCBI Gene
Aliases
OAT4L, RST, UAT, URAT1, hURAT1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96S37Solute carrier family 22 member 1255328Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464182Q96S37Espacenet
EP 4640849 A22025-10-291503Q96S37Espacenet
EP 4641201 A22025-10-2910204Q96S37Espacenet
JP 2025529142 A2025-09-044051Q96S37Espacenet
US 12371689 B22025-07-294051Q96S37Espacenet
JP 2025519096 A2025-06-241503Q96S37Espacenet
JP 2025517969 A2025-06-1210204Q96S37Espacenet
KR 1020240135628 A2024-09-116Q96S37Espacenet
US 11446398 B22022-09-2080768Q96S37Espacenet
US 11400116 B22022-08-025868Q96S37Espacenet

1 to 10 of 27

See all 27 patents

Drugs8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARHALOFENATECHEMBL2103824Solute carrier family 22 member 12 inhibitorINHIBITORChEMBL
BENZBROMARONECHEMBL388590Solute carrier family 22 member 12 inhibitorINHIBITORChEMBL
DOTINURADCHEMBL4594446Solute carrier family 22 member 12 inhibitorINHIBITORChEMBL
LESINURADCHEMBL2105720Solute carrier family 22 member 12 inhibitorINHIBITORChEMBL
PRATOSARTANCHEMBL41194Solute carrier family 22 member 12 inhibitorINHIBITORChEMBL
SHR-4640CHEMBL3746329Solute carrier family 22 member 12 inhibitorINHIBITORChEMBL
SULFINPYRAZONECHEMBL832Solute carrier family 22 member 12 inhibitorINHIBITORChEMBL
VERINURADCHEMBL3707347Solute carrier family 22 member 12 inhibitorINHIBITORChEMBL

Trials50

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07535034DOTINURADPHASE2ClinicalTrials.gov
NCT07362355SHR-4640PHASE2ClinicalTrials.gov
NCT07089888DOTINURADPHASE3ClinicalTrials.gov
NCT06056570DOTINURADPHASE1/PHASE2ClinicalTrials.gov
NCT05513976SHR-4640PHASE2ClinicalTrials.gov
NCT05007392DOTINURADPHASE32025-07-30ClinicalTrials.gov
NCT04956432SHR-4640PHASE3ClinicalTrials.gov
NCT04180982SHR-4640PHASE2ClinicalTrials.gov
NCT04157959SHR-4640PHASE1ClinicalTrials.gov
NCT04052932SHR-4640PHASE3ClinicalTrials.gov

1 to 10 of 50

See all 50 trials

NIH grants622

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC22A12 papersNewest fiscal year
R01DK109392The Role in OAT1 in Uremia82025
R01DK112042Glomerular and Tubular Function in the Diabetic Kidney72025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal72025
P30ES006694Southwest Environmental Health Sciences Center42025
ZIAAG000513Healthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS)42025
R01AR065944NOVEL METABOLITE AND MICROBIOTA PATHWAYS FOR HYPERURICEMIA AND GOUT32025
T32EB009380Training in Multi-scale Analysis of Biological Structure and Function32025
P30AR072571Boston University CCCR22025
P30DK056350Nutrition Obesity Research Center (NORC)22025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)22025

1 to 10 of 622Source NIH's project files

See all 622 nih grants

Papers1,555

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PFOS increases cellular uric acid content and the abundance of URAT1 and GLUT9 in HK-2 cells.Ecotoxicol Environ Saf202642801899PubTator, text miningPubMed
Associations of Genetic Variants in Uric Acid Transporter Genes With Salt Sensitivity, Longitudinal Blood Pressure Changes, and Incident Hypertension in Chinese Adults.J Clin Hypertens (Greenwich)202642745169PubTator, text miningPubMed
Genotype-Informed Characterization of Mild Renal Hypouricemia.Kidney Int Rep202642733763PubTator, text miningPubMed
A Dose-Escalation Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of HP501 in Male Chinese Gout Patients with Hyperuricemia.Clin Pharmacol Drug Dev202642717749PubTator, text miningPubMed
URAT1 inhibition in hyperuricemia and gout: from transporter biology to clinical precision therapy.Front Immunol202642676557PubTator, text miningPubMed
Purine-Metabolism Reprogramming Associated with Failed-Repair Proximal Tubule States in the AKI-to-CKD Transition.Metabolites202642646274PubTator, text miningPubMed
Losartan, uric acid, and cardiometabolic disease: beyond blood pressure control.Hypertens Res202642587046PubTator, text miningPubMed
Sodium butyrate upregulates URAT1-mediated urate reabsorption in HK2 cells by activating FFAR2/p38 MAPK/ELK1/ARRB2 axis and relieving NF-κB-HNF1β competitive binding.Biochem Pharmacol202642546882PubTator, text miningPubMed
Hirudin Attenuates Uric Acid-Induced Renal Tubular Injury via TNFRSF6B-Mediated Suppression of NF-κB Signaling.Pharmacol Res Perspect202642538608PubTator, text miningPubMed
Real-World Effectiveness and Safety of Dotinurad in Chinese Patients with Gout: A Comparative Analysis.Drugs Real World Outcomes202642538516PubTator, text miningPubMed

1 to 10 of 1,555

See all 1,555 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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