Gene · 116085
SLC22A12: solute carrier family 22 member 12
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC22A12: solute carrier family 22 member 12. Genes, record 116085. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/116085
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96S37 | Solute carrier family 22 member 12 | 553 | 28 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 64182 | Q96S37 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1503 | Q96S37 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10204 | Q96S37 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4051 | Q96S37 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4051 | Q96S37 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1503 | Q96S37 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10204 | Q96S37 | Espacenet |
| KR 1020240135628 A | 2024-09-11 | 6 | Q96S37 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80768 | Q96S37 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 5868 | Q96S37 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs8
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ARHALOFENATE | CHEMBL2103824 | Solute carrier family 22 member 12 inhibitor | INHIBITOR | ChEMBL |
| BENZBROMARONE | CHEMBL388590 | Solute carrier family 22 member 12 inhibitor | INHIBITOR | ChEMBL |
| DOTINURAD | CHEMBL4594446 | Solute carrier family 22 member 12 inhibitor | INHIBITOR | ChEMBL |
| LESINURAD | CHEMBL2105720 | Solute carrier family 22 member 12 inhibitor | INHIBITOR | ChEMBL |
| PRATOSARTAN | CHEMBL41194 | Solute carrier family 22 member 12 inhibitor | INHIBITOR | ChEMBL |
| SHR-4640 | CHEMBL3746329 | Solute carrier family 22 member 12 inhibitor | INHIBITOR | ChEMBL |
| SULFINPYRAZONE | CHEMBL832 | Solute carrier family 22 member 12 inhibitor | INHIBITOR | ChEMBL |
| VERINURAD | CHEMBL3707347 | Solute carrier family 22 member 12 inhibitor | INHIBITOR | ChEMBL |
Trials50
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07535034 | DOTINURAD | PHASE2 | ClinicalTrials.gov | |
| NCT07362355 | SHR-4640 | PHASE2 | ClinicalTrials.gov | |
| NCT07089888 | DOTINURAD | PHASE3 | ClinicalTrials.gov | |
| NCT06056570 | DOTINURAD | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT05513976 | SHR-4640 | PHASE2 | ClinicalTrials.gov | |
| NCT05007392 | DOTINURAD | PHASE3 | 2025-07-30 | ClinicalTrials.gov |
| NCT04956432 | SHR-4640 | PHASE3 | ClinicalTrials.gov | |
| NCT04180982 | SHR-4640 | PHASE2 | ClinicalTrials.gov | |
| NCT04157959 | SHR-4640 | PHASE1 | ClinicalTrials.gov | |
| NCT04052932 | SHR-4640 | PHASE3 | ClinicalTrials.gov |
1 to 10 of 50
See all 50 trialsNIH grants622
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC22A12 papers | Newest fiscal year |
|---|---|---|---|
| R01DK109392 | The Role in OAT1 in Uremia | 8 | 2025 |
| R01DK112042 | Glomerular and Tubular Function in the Diabetic Kidney | 7 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 7 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 4 | 2025 |
| ZIAAG000513 | Healthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS) | 4 | 2025 |
| R01AR065944 | NOVEL METABOLITE AND MICROBIOTA PATHWAYS FOR HYPERURICEMIA AND GOUT | 3 | 2025 |
| T32EB009380 | Training in Multi-scale Analysis of Biological Structure and Function | 3 | 2025 |
| P30AR072571 | Boston University CCCR | 2 | 2025 |
| P30DK056350 | Nutrition Obesity Research Center (NORC) | 2 | 2025 |
| P30ES005022 | Rutgers Center for Environmental Exposure and Disease (CEED) | 2 | 2025 |
1 to 10 of 622Source NIH's project files
See all 622 nih grantsPapers1,555
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| PFOS increases cellular uric acid content and the abundance of URAT1 and GLUT9 in HK-2 cells. | Ecotoxicol Environ Saf | 2026 | 42801899 | PubTator, text mining | PubMed |
| Associations of Genetic Variants in Uric Acid Transporter Genes With Salt Sensitivity, Longitudinal Blood Pressure Changes, and Incident Hypertension in Chinese Adults. | J Clin Hypertens (Greenwich) | 2026 | 42745169 | PubTator, text mining | PubMed |
| Genotype-Informed Characterization of Mild Renal Hypouricemia. | Kidney Int Rep | 2026 | 42733763 | PubTator, text mining | PubMed |
| A Dose-Escalation Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of HP501 in Male Chinese Gout Patients with Hyperuricemia. | Clin Pharmacol Drug Dev | 2026 | 42717749 | PubTator, text mining | PubMed |
| URAT1 inhibition in hyperuricemia and gout: from transporter biology to clinical precision therapy. | Front Immunol | 2026 | 42676557 | PubTator, text mining | PubMed |
| Purine-Metabolism Reprogramming Associated with Failed-Repair Proximal Tubule States in the AKI-to-CKD Transition. | Metabolites | 2026 | 42646274 | PubTator, text mining | PubMed |
| Losartan, uric acid, and cardiometabolic disease: beyond blood pressure control. | Hypertens Res | 2026 | 42587046 | PubTator, text mining | PubMed |
| Sodium butyrate upregulates URAT1-mediated urate reabsorption in HK2 cells by activating FFAR2/p38 MAPK/ELK1/ARRB2 axis and relieving NF-κB-HNF1β competitive binding. | Biochem Pharmacol | 2026 | 42546882 | PubTator, text mining | PubMed |
| Hirudin Attenuates Uric Acid-Induced Renal Tubular Injury via TNFRSF6B-Mediated Suppression of NF-κB Signaling. | Pharmacol Res Perspect | 2026 | 42538608 | PubTator, text mining | PubMed |
| Real-World Effectiveness and Safety of Dotinurad in Chinese Patients with Gout: A Comparative Analysis. | Drugs Real World Outcomes | 2026 | 42538516 | PubTator, text mining | PubMed |
1 to 10 of 1,555
See all 1,555 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/116085
GET https://conductscience.org/api/genes/v1/116085/patents?page=2