Gene · 1161
ERCC8: ERCC excision repair 8, CSA ubiquitin ligase complex subunit
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ERCC8: ERCC excision repair 8, CSA ubiquitin ligase complex subunit. Genes, record 1161. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1161
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13216 | DNA excision repair protein ERCC-8 | 396 | 16 | Ensembl, GeneID, HGNC |
Source UniProt
Patents41
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4524569 A2 | 2025-03-19 | 2 | Q13216 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 372 | Q13216 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 6138 | Q13216 | Espacenet |
| US 12023339 B2 | 2024-07-02 | 2 | Q13216 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 372 | Q13216 | Espacenet |
| US 11591295 B2 | 2023-02-28 | 2 | Q13216 | Espacenet |
| US 11504404 B2 | 2022-11-22 | 193 | Q13216 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 29036 | Q13216 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 132007 | Q13216 | Espacenet |
| US 11160807 B1 | 2021-11-02 | 2 | Q13216 | Espacenet |
1 to 10 of 41
See all 41 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,116
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ERCC8 papers | Newest fiscal year |
|---|---|---|---|
| R35GM118102 | Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock | 9 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 8 | 2025 |
| ZIAAI001176 | Pregnancy Malaria Vaccine development | 8 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 7 | 2025 |
| ZIAAI001134 | Malaria Pathogenesis in young children and vaccine discovery | 6 | 2025 |
| R01GM102362 | Molecular Mechanisms for DNA Damage Processing by Transcription Machinery | 5 | 2025 |
| ZIAAG000741 | Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| R01ES033414 | DNA Adduct Detection and Repair in Mammalian Cells | 4 | 2025 |
1 to 10 of 1,116Source NIH's project files
See all 1,116 nih grantsPapers2,033
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Clinical and genomic characterization of corpus callosum abnormalities (CCA) in 107 Tunisian patients using a stepwise diagnostic approach. | Front Genet | 2026 | 42807679 | PubTator, text mining | PubMed |
| Association of thigh muscle status and longitudinal changes assessed by MRI with subsequent total hip arthroplasty: insights from the osteoarthritis initiative. | Arthroplasty | 2026 | 42675516 | PubTator, text mining | PubMed |
| Surgical correction of severe rigid equinovarus deformity in Cockayne syndrome: perioperative challenges and multidisciplinary management-a case report. | J Surg Case Rep | 2026 | 42634649 | PubTator, text mining | PubMed |
| Dynamic muscle loss and metabolic dysregulation in sepsis-associated muscle wasting: an integrated ultrasound and metabolomics study. | Front Med (Lausanne) | 2026 | 42583239 | PubTator, text mining | PubMed |
| AAV-mediated gene therapy demonstrates phenotypic rescue in a mouse model of Cockayne syndrome. | J Clin Invest | 2026 | 42531030 | PubTator, text mining | PubMed |
| Recent developments and future directions for competing stimulus assessments. | J Appl Behav Anal | 2026 | 42522545 | PubTator, text mining | PubMed |
| Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations. | J Invest Dermatol | 2026 | 42373067 | PubTator, text mining | PubMed |
| Targeting the Mitochondrial Phenotype in Cockayne Syndrome Patient Cells: From Bioenergetic Fragility to Pharmacologic Rescue. | bioRxiv | 2026 | 42232504 | PubTator, text mining | PubMed |
| Transcription-coupled nucleotide excision repair protects against genomic instability and cell death induced by the liver toxin methyleugenol. | Cell Death Dis | 2026 | 42156710 | PubTator, text mining | PubMed |
| Design and initial characterization of a novel mini-promoter for gene therapies targeting the central nervous system. | Mol Ther Adv | 2026 | 42137269 | PubTator, text mining | PubMed |
1 to 10 of 2,033
See all 2,033 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/1161
GET https://conductscience.org/api/genes/v1/1161/patents?page=2