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Gene · 1161

ERCC8: ERCC excision repair 8, CSA ubiquitin ligase complex subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ERCC8: ERCC excision repair 8, CSA ubiquitin ligase complex subunit. Genes, record 1161. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/1161

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Gene

Symbol
ERCC8
HGNC
Name
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
HGNC
NCBI Gene ID
1161
NCBI Gene
HGNC ID
HGNC:3439
HGNC
Ensembl
ENSG00000049167
NCBI Gene
Aliases
CKN1, CSA, UVSS2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13216DNA excision repair protein ERCC-839616Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4524569 A22025-03-192Q13216Espacenet
EP 4464338 A22024-11-20372Q13216Espacenet
JP 2024123008 A2024-09-106138Q13216Espacenet
US 12023339 B22024-07-022Q13216Espacenet
US 11680268 B22023-06-20372Q13216Espacenet
US 11591295 B22023-02-282Q13216Espacenet
US 11504404 B22022-11-22193Q13216Espacenet
US 11446398 B22022-09-2029036Q13216Espacenet
JP 2022524081 A2022-04-27132007Q13216Espacenet
US 11160807 B12021-11-022Q13216Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,116

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleERCC8 papersNewest fiscal year
R35GM118102Molecular Mechanism of Mammalian DNA Excision Repair and the Circadian Clock92025
P01CA092584Structural Cell Biology of DNA Repair Machines82025
ZIAAI001176Pregnancy Malaria Vaccine development82025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control72025
ZIAAI001134Malaria Pathogenesis in young children and vaccine discovery62025
R01GM102362Molecular Mechanisms for DNA Damage Processing by Transcription Machinery52025
ZIAAG000741Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability52025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
R01ES033414DNA Adduct Detection and Repair in Mammalian Cells42025

1 to 10 of 1,116Source NIH's project files

See all 1,116 nih grants

Papers2,033

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical and genomic characterization of corpus callosum abnormalities (CCA) in 107 Tunisian patients using a stepwise diagnostic approach.Front Genet202642807679PubTator, text miningPubMed
Association of thigh muscle status and longitudinal changes assessed by MRI with subsequent total hip arthroplasty: insights from the osteoarthritis initiative.Arthroplasty202642675516PubTator, text miningPubMed
Surgical correction of severe rigid equinovarus deformity in Cockayne syndrome: perioperative challenges and multidisciplinary management-a case report.J Surg Case Rep202642634649PubTator, text miningPubMed
Dynamic muscle loss and metabolic dysregulation in sepsis-associated muscle wasting: an integrated ultrasound and metabolomics study.Front Med (Lausanne)202642583239PubTator, text miningPubMed
AAV-mediated gene therapy demonstrates phenotypic rescue in a mouse model of Cockayne syndrome.J Clin Invest202642531030PubTator, text miningPubMed
Recent developments and future directions for competing stimulus assessments.J Appl Behav Anal202642522545PubTator, text miningPubMed
Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.J Invest Dermatol202642373067PubTator, text miningPubMed
Targeting the Mitochondrial Phenotype in Cockayne Syndrome Patient Cells: From Bioenergetic Fragility to Pharmacologic Rescue.bioRxiv202642232504PubTator, text miningPubMed
Transcription-coupled nucleotide excision repair protects against genomic instability and cell death induced by the liver toxin methyleugenol.Cell Death Dis202642156710PubTator, text miningPubMed
Design and initial characterization of a novel mini-promoter for gene therapies targeting the central nervous system.Mol Ther Adv202642137269PubTator, text miningPubMed

1 to 10 of 2,033

See all 2,033 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/1161

GET https://conductscience.org/api/genes/v1/1161/patents?page=2